陳垣崇博士

通信研究員
中央研究院院士
  • 02-27899081 (Lab) (Room No: N807)
  • 02-27899085 (Fax)

Specialty:
  • Human Genetics
  • Genomic Medicine

Education and Positions:
  • M.D., Ph.D. Columbia University


研究主題為轉譯醫學研究,將基礎基因醫藥研究應用到臨床醫學。

 

研究方向:

 

1. 鑑定與嚴重藥物不良反應及常見多因子疾病,如第二型糖尿病、躁鬱症、川崎症,有關的新穎基因或標的物。

 

2. 研究史帝文強生症候群的遺傳學與分子機轉,進行特定HLA-B對偶基因及T細胞接受器在引起角細胞死亡過程中如何調節細胞毒性。

 

3. 利用酵素替代性療法已可有效治療龐貝氏症,但治療瓶頸,如病患產生中和抗體或發生骨骼變異,尚待進一步研究。

Our Team
Team photo

期刊 273 專書 33

  1. Takeuchi Fumihiko et al. (95 co-authors) Interethnic analyses of blood pressure loci in populations of East Asian and European descent. Nature Communications 9, 5052 (2018-11) [JCR] [WOS]
  2. Kishnani P and (Chen YT) Glycogen storage diseases and other inherited disorders of carbohydrate metabolism. Harrison’s Principles of Internal Medicine Part 12, Section 5, #412 (2018-08-29) [JCR] [WOS]
  3. Phillips EJ, Sukasem C, Whirl-Carrillo M, Müller DJ, Dunnenberger HM, Chantratita W, Goldspiel B, (Chen YT), Carleton BC, George Jr. AL, Mushiroda T, Klein T, Gammal RS, Pirmohamed M Clinical pharmacogenetics implementation consortium guideline for HLA genotype and use of carbamazepine and oxcarbazepine. CLINICAL PHARMACOLOGY & THERAPEUTICS 103(4), 574-581 (2018-04) [JCR] [WOS]
  4. Chen SP, Fuh JL, Chung MY, Lin YC, Liao YC, Wang YF, Hsu CL, Yang UC, Lin MW, Chiou JJ, Wang PJ, Chen PK, Fan PC, Wu JY, (Chen YT), Kao LS, Fann CSJ, Wang SJ Genome-wide assocation study identifies novel susceptibility loci for migraine in Han Chinese resided in Taiwan. CEPHALALGIA 38(3), 466-475 (2018-03) [JCR] [WOS]
  5. Kubo K, Ohara M, Tachikawa M, Cavallari LH, Lee MTM, Wen MS, Scordo MG, Nutescue EA, Perera MA, Miyajima A, Kaneko N, Pengo V, Padrini R, (Chen YT), Takahashi H Population differences in S-warfarin pharmacokinetics among African Americans, Asians and whites: their influence on pharmacogenetic dosing algorithms. PHARMACOGENOMICS JOURNAL 17(6), 494-500 (2017-12) [JCR] [WOS]
  6. Lee TH, Ko TM, Chen CH, Chang YJ, Lu LS, Chang CH, Huang KL, Chang TY, Lee JD, Chang KC, Yang JT, Wen MS, Wang CY, Chen YT, Chen TC, Chou SY, Lee MTM, (Chen YT)* and Wu JY* A genome-wide association study links small-vessel ischemic stroke to autophagy. SCIENTIFIC REPORTS 9, 15229 (2017-11) [JCR] [WOS]
  7. Chiang HL, Wu JY, (Chen YT)* Identification of functional single nucleotide polymorphisms in the branchpoint site. HUMAN GENOMICS 11, 27 (2017-11) [JCR] [WOS]
  8. Chang CJ, Chen CH, Chen BM, Su YC, Chen YT, Hershfield MS, Lee MTM, Cheng TL, (Chen YT)*, Roffler SR*,and Wu JY* A genome-wide association study identifies a novel susceptibility locus for the immunogenicity of polyethylene glycol. NATURE COMMUNICATIONS 8, 522 (2017-09) [JCR] [WOS]
  9. Shen LF, Chen YJ, Liu KM, Saleem Haddad AN, Song IW, Roan HY, Chen LY, Yen JJY, Chen YJ, Wu JY, (Chen YT)*. Role of S-palmitoylation by ZDHHC13 in mitochondrial function and metabolism in liver. Scientific Reports 7(1), 2182 (2017-05-19) [JCR] [WOS]
  10. Spracklen CN et al. (114 co-authors) Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels. Human Molecular Genetics 26(9), 1770-1784 (2017-05-01) [JCR] [WOS]