Dr. Lee, Te-Chang 's publons link picture

李德章博士

兼任研究員
  • 02-27899145 (Lab) (Room No: N247)
  • 02-26523055 (Office)
  • 02-27829142 (Fax)

Specialty:
  • Genetic and Molecular Toxicology
  • Cancer Biology
  • Pharmacology
  • Biobank

Education and Positions:
  • Ph.D. National Taiwan University


本研究室近年來聚焦於研發新穎抗癌藥物。經與本所醫藥化學家蘇燦隆博士之合作,近年來我們驗證許多新合成雙官能烷化劑的抗癌活性,部分化合物甚具抑制多重抗藥性癌細胞之活性。最近的興趣為設計合成具有雙功能的雜合分子。現已成功將具抑制血管新生之酞嗪與可造成DNA雙股連接之雙(羥甲基)吡咯接合成雜合分子,並驗證其具有廣效之抗癌作用。

本人亦擔任臺灣人體生物資料庫之代表人。臺灣人體生物資料庫之目標為收集20萬社區一般民眾之健康資訊與生物檢體,做為生醫研究之基盤建設。目前已收存超過14萬人之健康資訊及生物檢體,並可釋出超過 10萬筆全基因體定型之資料。


 
Our Team
Team photo

期刊 172 專書 7

  1. Chen TL, Patel AS, Jain V, Kuppusamy R, Lin YW, Hou MH, Su TL and (Lee TC)* Discovery of oral anticancer 1,2-bis(hydroxymethyl)benzo[g]pyrrolo[2,1‑a]phthalazine hybrids that inhibit angiogenesis and induce DNA cross-links. Journal of Medicinal Chemistry 64(17), 12469-12486 (2021-09) [JCR] [WOS]
  2. Wu MM, Hsieh FI, Hsu LI, (Lee TC), Chiou HY and Chen CJ GT-repeat polymorphism in the HO-1 gene promoter is associated with risk of liver cancer: A follow-up study from arseniasis-endemic areas in Taiwan. Journal of Clinical Medicine 10(7), 1489 (2021-04) [JCR] [WOS]
  3. Wei CY, Yang JH, Yeh EC, Tsai MF, Kao HJ, Lo CZ, Chang LP, Lin WJ, Hsieh FJ, Belsare S, Bhaskar A, Su MW, (Lee TC), Lin YL, Liu FT, Shen CY, Li LH, Chen CH, Wall JD, Wu JY and Kwok PY Genetic profiles of 103,106 individuals in the Taiwan Biobank provide insights into the health and history of Han Chinese. NPJ Genomic Medicine 6(1), 10 (2021-02) [JCR] [WOS]
  4. Regmi Prabha, Lai Kuo-Chu, Liu Chung-Ji, (Lee Te-Chang)* SAHA Overcomes 5-FU Resistance in IFIT2-Depleted Oral Squamous Cell Carcinoma Cells. Cancers 12(12), 3527 (2020-11) [JCR] [WOS]
  5. Patel Anilkumar S., Jain Vicky, Rao Vaikar Navakanth, Lin Yi-Wen, Shah Anamik, Lai Kuo-Chu, Su Tsann-Long, (Lee Te-Chang*) Design, synthesis and antitumour evaluation of pyrrolo[1,2-f]-phenanthridine and dibenzo[f,h]pyrrolo[1,2-b]isoquinoline derivatives. European Journal of Medicinal Chemistry 202,112516 (2020-09) [JCR] [WOS]
  6. Hu Wei-Chun, Teo Wan-Huai, Huang Tung-Fu, (Lee Te-Chang), Lo Jeng-Fan Combinatorial Low Dose Arsenic Trioxide and Cisplatin Exacerbates Autophagy via AMPK/STAT3 Signaling on Targeting Head and Neck Cancer Initiating Cells. Frontiers in Oncology 10, 463 (2020-04) [JCR] [WOS]
  7. Pidugu VK, Pidugu HB, Wu MM, Liu CJ and (Lee TC)* Emerging functions of human IFIT proteins in cancer. Frontiers in Molecular Biosciences-Molecular Diagnostics and Therapeutics 6 (2019-12) [JCR] [WOS]
  8. Lin Ming-Shiu, Hong Tse-Ming, Chou Ting-Hung, Yang Shuenn-Chen, Chung Wei-Chia, Weng Chia-Wei, Tsai Mei-Ling, Cheng Ting-Jen Rachel, Chen Jeremy J.W., (Lee Te-Chang), Wong Chi-Huey, Chein Rong-Jie, Yang Pan-Chyr 4(1H)-quinolone derivatives overcome acquired resistance to anti-microtubule agents by targeting the colchicine site of β-tubulin. European Journal of Medicinal Chemistry 181,111584 (2019-11) [JCR] [WOS]
  9. Pidugu VK, Wu MM, Yen AH, Pidugu HB, Chang KW, Liu CJ, (Lee TC)* IFIT1 and IFIT3 promote oral squamous cell carcinoma metastasis and contribute to the anti-tumor effect of gefitinib via enhancing p-EGFR recycling.. Oncogene 38(17), 3232-3247 (2019-04) [JCR] [WOS]
  10. Chang SM, Jain V, Chen TL, Patel AS, Pidugu HB, Lin YW, Wu MH, Huang JR, Wu HC, Shah A, Su TL, (Lee TC)* Design and Synthesis of 1,2-Bis(hydroxymethyl)pyrrolo[2,1- a]phthalazine Hybrids as Potent Anticancer Agents that Inhibit Angiogenesis and Induce DNA Interstrand Cross-links.. Journal of medicinal chemistry 62(5), 2404-2418 (2019-03) [JCR] [WOS]

- 博士後研究 -
member
昂丹堤
Kuppusamy, Ramajayam
藍加亞
member
以馬內利
- 研究助理 -
member
林憶雯
- 學生 -
member
倪翊庭
Regmi, Prabha
白莉敏
Rao Vaikar, Navakanth
羅凱
- 昔日夥伴 -
Chang, Su-Ming
張書銘
Chu, Chun-Ho
朱俊合
Ho, I-Ching
何宜靜
member
鄧宇翔
Pidugu, Hima Bindu
希瑪冰杜
Hong, Shiao-Ya
洪小雅
Mar, Ai-Chung
馬璦中
Liao, Yi-Chun
廖翊君
Wang, Hsiu‑Hua
王秀華
Pidugu, Vijaya Kumar
韋加亞
Salim, Shaimaa Ahmad
夏依瑪Sandy
Chen, Tai-Lin
陳泰霖
Lin, Li-Fang
林麗芳
member
吳明錫
Jain, Vicky Devendra
JainVicky