Dr. Lee, Te-Chang 's publons link picture

Dr. Lee, Te-Chang

Adjunct Research Fellow
  • 02-27899145 (Lab) (Room No: N247)
  • 02-26523055 (Office)
  • 02-27829142 (Fax)
Specialty:
  • Genetic and Molecular Toxicology
  • Cancer Biology
  • Pharmacology
  • Biobank
Education and Positions:

  • Ph.D. National Taiwan University

My current research focuses on the development of novel anticancer drugs. Via collaboration with Dr. T. L. Su, a medicinal chemist in IBMS, we have demonstrated that several newly synthesized bifunctional alkylating agents are potent anticancer agents. Several of them were even able to overcome the MDR cancer cells. Our recent interest is to design hybrid molecules with dual functions. We have successfully conjugated phthalazine and bis(hydroxymethyl)pyrrole pharmacophores to form hybrids bearing antiangiogenesis and DNA interstrand crosslinking activities. We have demonstrated these hybrids displaying a broad-spectrum anticancer activity.

I served as PI of Taiwan Biobank (https://www.twbiobank.org.tw). The Taiwan Biobank is a national scientific infrastructure providing the biomedical research community access to biological specimens and information collected from the genereal population in Taiwan. The objective Taiwan Biobank is to recruit 200,000 voluntary participants. Currently, we have recruited 148,291 participants and produced more than 100,000 whole genome genotyping. 

Our Team
Team photo

Journal 172 Book 7

  1. Chen TL, Patel AS, Jain V, Kuppusamy R, Lin YW, Hou MH, Su TL and (Lee TC)* Discovery of oral anticancer 1,2-bis(hydroxymethyl)benzo[g]pyrrolo[2,1‑a]phthalazine hybrids that inhibit angiogenesis and induce DNA cross-links. Journal of Medicinal Chemistry 64(17), 12469-12486 (2021-09) [JCR] [WOS]
  2. Wu MM, Hsieh FI, Hsu LI, (Lee TC), Chiou HY and Chen CJ GT-repeat polymorphism in the HO-1 gene promoter is associated with risk of liver cancer: A follow-up study from arseniasis-endemic areas in Taiwan. Journal of Clinical Medicine 10(7), 1489 (2021-04) [JCR] [WOS]
  3. Wei CY, Yang JH, Yeh EC, Tsai MF, Kao HJ, Lo CZ, Chang LP, Lin WJ, Hsieh FJ, Belsare S, Bhaskar A, Su MW, (Lee TC), Lin YL, Liu FT, Shen CY, Li LH, Chen CH, Wall JD, Wu JY and Kwok PY Genetic profiles of 103,106 individuals in the Taiwan Biobank provide insights into the health and history of Han Chinese. NPJ Genomic Medicine 6(1), 10 (2021-02) [JCR] [WOS]
  4. Regmi Prabha, Lai Kuo-Chu, Liu Chung-Ji, (Lee Te-Chang)* SAHA Overcomes 5-FU Resistance in IFIT2-Depleted Oral Squamous Cell Carcinoma Cells. Cancers 12(12), 3527 (2020-11) [JCR] [WOS]
  5. Patel Anilkumar S., Jain Vicky, Rao Vaikar Navakanth, Lin Yi-Wen, Shah Anamik, Lai Kuo-Chu, Su Tsann-Long, (Lee Te-Chang*) Design, synthesis and antitumour evaluation of pyrrolo[1,2-f]-phenanthridine and dibenzo[f,h]pyrrolo[1,2-b]isoquinoline derivatives. European Journal of Medicinal Chemistry 202,112516 (2020-09) [JCR] [WOS]
  6. Hu Wei-Chun, Teo Wan-Huai, Huang Tung-Fu, (Lee Te-Chang), Lo Jeng-Fan Combinatorial Low Dose Arsenic Trioxide and Cisplatin Exacerbates Autophagy via AMPK/STAT3 Signaling on Targeting Head and Neck Cancer Initiating Cells. Frontiers in Oncology 10, 463 (2020-04) [JCR] [WOS]
  7. Pidugu VK, Pidugu HB, Wu MM, Liu CJ and (Lee TC)* Emerging functions of human IFIT proteins in cancer. Frontiers in Molecular Biosciences-Molecular Diagnostics and Therapeutics 6 (2019-12) [JCR] [WOS]
  8. Lin Ming-Shiu, Hong Tse-Ming, Chou Ting-Hung, Yang Shuenn-Chen, Chung Wei-Chia, Weng Chia-Wei, Tsai Mei-Ling, Cheng Ting-Jen Rachel, Chen Jeremy J.W., (Lee Te-Chang), Wong Chi-Huey, Chein Rong-Jie, Yang Pan-Chyr 4(1H)-quinolone derivatives overcome acquired resistance to anti-microtubule agents by targeting the colchicine site of β-tubulin. European Journal of Medicinal Chemistry 181,111584 (2019-11) [JCR] [WOS]
  9. Pidugu VK, Wu MM, Yen AH, Pidugu HB, Chang KW, Liu CJ, (Lee TC)* IFIT1 and IFIT3 promote oral squamous cell carcinoma metastasis and contribute to the anti-tumor effect of gefitinib via enhancing p-EGFR recycling.. Oncogene 38(17), 3232-3247 (2019-04) [JCR] [WOS]
  10. Chang SM, Jain V, Chen TL, Patel AS, Pidugu HB, Lin YW, Wu MH, Huang JR, Wu HC, Shah A, Su TL, (Lee TC)* Design and Synthesis of 1,2-Bis(hydroxymethyl)pyrrolo[2,1- a]phthalazine Hybrids as Potent Anticancer Agents that Inhibit Angiogenesis and Induce DNA Interstrand Cross-links.. Journal of medicinal chemistry 62(5), 2404-2418 (2019-03) [JCR] [WOS]
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