Dr. Shih, Hsiu-Ming 's publons link picture

施修明博士

研究員
  • 2789-9060 (Lab) (Room No: N605)
  • 2652-3520 (Office)
  • 2782-7654 (Fax)
Specialty:
  • Protein-protein Interaction & Modification
  • Cancer Cell Signaling
  • Transcriptional Control
Education and Positions:

  • Ph.D. Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota

搏鬥癌症的類泛素化

 

類泛素(SUMO) 修飾調控了許多細胞運作途徑。本實驗室研究主要聚焦於蛋白質 sumoylation 是如何被調節以及類泛素化蛋白質在癌症中的功能進行分子機制的探討，尤其是 sumoylation在幾種類型的癌症中普遍升高。另外，我們也證明了其他幾種蛋白質後轉譯修飾，如磷酸化和乙醯化，可以控制蛋白質 sumoylation。由於 SUMO 訊息途徑被認為是癌症中需要依靠的非癌基因成癮(non-oncogene addiction)，因此靶向 SUMO 機制和/或 sumoylated 蛋白質不僅可以了解與癌症相關的 sumoylation 的分子機轉，亦可增加抗癌藥物靶點的選擇。目前研究以剖析癌症相關的 SUMO 化因子的意義以及開發針對癌症中的 SUMO 結合和接合的治療劑。

期刊 100 專書 0

  1. He Y. Pasupala, N, Zhi H, Dorjbal B, Hussain I, Shih HM, Bhattacharyya S, Biswas R, Semmes OJ, Waldmann TA, Snow AL, and Giam CZ NF-κB-Induced R-loop Accumulation and DNA Damage Select for Nucleotide Excision Repair Deficiencies in Adult T-cell Leukemia. PNAS 118(10), e2005568118 (2021-03-09) [JCR] [WOS]
  2. Huang YS, Lu KC, Chao HW, Chen A, Chao TK, Guo CY, Hsieh HY, Shih HM, Sytwu HK, Wu CC The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells.. J Cell Physiol 236(3), 2023-2035 (2021-03) [JCR] [WOS]
  3. Hsieh YL, Su FY, Tsai LK, Huang CC, Ko YL, Su LW, Chen KY, Shih HM, Hu CM, Lee WH NPGPx-mediated adaptation to oxidative stress protects motor neurons from degeneration in aging by directly modulating O-GlcNAcase. Cell Rep 29(8), 2134-2143.e7 (2019-11) [JCR] [WOS]
  4. Ma HY, Lu CY, Tsao KC, Shih HM, Cheng AL, Huang LM, Chang LY Association of EV71 3C polymorphisms with clinical severity. J Microbiol Immunol Infect. 51(5), 608-613 (2018-10) [JCR] [WOS]
  5. Chen SY, Ho CT, Liu WW, Lucanic M, Shih HM, Huang PH, Cheng HJ Regulation of axon repulsion by MAX-1 sumoylation and AP-3. Proc Natl Acad Sci USA 115(35), E8236-E8245 (2018-08) [JCR] [WOS]
  6. Huang YS, Lu KC, Chao TK, Chen JS, Chen A, Guo CY, Hsieh HY, Shih HM, Sytwu HK and Wu CC Role of melatonin receptor 1A and pituitary homeobox-1 coexpression in protecting tubular epithelial cells in membranous nephropathy. J Pineal Res 65(1), e12482 (2018-08) [JCR] [WOS]
  7. Hu LY, Chang CC, Huang YS, Chou WC, Lin YM, Ho CC, Chen WT, Shih HM, Hsiung CN, Wu PE, and Shen CY Sumoylation of XRCC1 activated by poly)ADP-ribosyl)ation regulates DNA repair. Hum Mol Genet. 27(13), 2306-2317 (2018-07) [JCR] [WOS]
  8. Chang CC, Huang YS, Lin YM, Lin CJ, Jeng JC, Liu SM, Ho TL, Chang RT, Changou C, Ho CC, Shih HM* The role of sentrin-specific protease 2 substrate recognition in TGF-b-induced tumorigenesis. Scientific Reports 8(1), 9786 (2018-06) [JCR] [WOS]
  9. Lin CY, YangST, Shen SC, Hsieh YC, Hsu FT, Chen CY, Chiang YH, Chuang JY, Chen KY, Hsu TI, Leong WC, Su YK, Lo WL, Yeh YS, Patria YN, Shih HM, Chang CC and Chou SY Serum amyloid A1 in combination with integrin V3 increases glioblastoma cells mobility and progression. Mol Oncol. 12(5), 756-771 (2018-05) [JCR] [WOS]
  10. Cheng CW, Chang CC, Patria YN, Chang RT, Liu YR, Li FA, Shih HM, Lin CY Sex hormone-binding globulin (SHBG) is a potential early diagnostic biomarker for gastric cancer. Cancer Medicine 7(1), 64-74 (2018-01) [JCR] [WOS]
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