Dr. Shih, Hsiu-Ming 's publons link picture

Dr. Shih, Hsiu-Ming

Research Fellow
  • 2789-9060 (Lab) (Room No: N605)
  • 2652-3520 (Office)
  • 2782-7654 (Fax)

Specialty:
  • Protein-protein Interaction & Modification
  • Cancer Cell Signaling
  • Transcriptional Control

Education and Positions:
  • Ph.D. Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota


Wrestling with SUMO in Cancer

 

SUMO modification is emerging as an important post-translational control of cellular events. My lab primarily focused on the molecular mechanisms as to how protein sumoylation is regulated and what consequence of a protein is sumoylated in cancer giving that sumoylation levels are elevated in several types of human cancer. We have demonstrated several other modifications such as phosphorylation and acetylation could control protein sumoylation. Since SUMO pathway has been considered as a non-oncogene addiction in cancer, targeting SUMO machinery and/or sumoylated substrates could not only understand the underlying mechanism of sumoylation associated with cancer but also increase the repertoire of druggable targets against cancer. Studies are undergoing to dissect the functional significances of cancer-associated sumoylated factors as well as to develop therapeutic agents in targeting SUMO conjugation and binding in cancer.

Journal 109 Book 0

  1. Hu CT, Lin CF, Shih HM, You RI, Wu WS, Chen YC Blockade of Src signaling prevented stemness gene expression and proliferation of patient-derived gastric cancer stem cells.. Tzu chi medical journal 37(1), 65-71 (2025) [JCR] [WOS]
  2. Shen HT, Hung CS, Davis C, Su CM, Liao LM, Shih HM, Lee KD, Ansar M, Lin RK Hypermethylation of the Gene Body in SRCIN1 Is Involved in Breast Cancer Cell Proliferation and Is a Potential Blood-Based Biomarker for Early Detection and a Poor Prognosis.. Biomolecules 14(5), 571 (2024) [JCR] [WOS]
  3. Huang YS, Lu KC, Chang YT, Ka SM, Guo CY, Hsieh HY, Shih HM, Sytwu HK, Wu CC Melatonin Alleviates Albumin-Induced Tubular Cell Injury by Activating Clock-Controlled Nuclear Enriched Abundant Transcript 1-Mediated Proliferation.. ACS pharmacology & translational science 7(11), 3607-3617 (2024) [JCR] [WOS]
  4. Yang HJ, Asakawa H, Li FA, Haraguchi T, Shih HM, Hiraoka Y A nuclear pore complex-associated regulation of SUMOylation in meiosis.. Genes to cells : devoted to molecular & cellular mechanisms 28(3), 188-201 (2023) [JCR] [WOS]
  5. Wu WS, Cheng CC, Lee YH, Wei JL, Chen RF, Lin CF, You RI, Chen YC, Shih HM, Hu CT, Chang HH, Lee MC, Chen YC Preclinical trial of targeting the Hic-5-mediated pathway to prevent the progression of hepatocellular carcinoma.. American journal of cancer research 13(10), 4903-4917 (2023) [JCR] [WOS]
  6. Yang TT, Chiang MF, Chang CC, Yang SY, Huang SW, Liao NS, Shih HM, Hsu W, Lin KI SENP2 restrains the generation of pathogenic Th17 cells in mouse models of colitis.. Communications biology 6(1), 629 (2023) [JCR] [WOS]
  7. Lee YH, Tsai YS, Chang CC, Ho CC, Shih HM, Chen HM, Lai HL, Lee CW, Lee YC, Liao YC, Yang UC, Cheng TH, Chern Y, Soong BW A PIAS1 Protective Variant S510G Delays polyQ Disease Onset by Modifying Protein Homeostasis.. Movement disorders : official journal of the Movement Disorder Society 37(4), 767-777 (2022) [JCR] [WOS]
  8. Huang YS, Wu CC, Chang CC, Huang SF, Kuo HY, Shih HM Reciprocal regulation of Daxx and PIK3CA promotes colorectal cancer cell growth.. Cellular and molecular life sciences : CMLS 79(7), 367 (2022) [JCR] [WOS]
  9. He Y. Pasupala, N, Zhi H, Dorjbal B, Hussain I, Shih HM, Bhattacharyya S, Biswas R, Semmes OJ, Waldmann TA, Snow AL, and Giam CZ NF-κB-Induced R-loop Accumulation and DNA Damage Select for Nucleotide Excision Repair Deficiencies in Adult T-cell Leukemia. PNAS 118(10), e2005568118 (2021-03-09) [JCR] [WOS]
  10. Huang YS, Lu KC, Chao HW, Chen A, Chao TK, Guo CY, Hsieh HY, Shih HM, Sytwu HK, Wu CC The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells.. J Cell Physiol 236(3), 2023-2035 (2021-03) [JCR] [WOS]