Dr. Shih, Hsiu-Ming 's publons link picture

Dr. Shih, Hsiu-Ming

Research Fellow
  • 2789-9060 (Lab) (Room No: N605)
  • 2652-3520 (Office)
  • 2782-7654 (Fax)

  • Protein-protein Interaction & Modification
  • Cancer Cell Signaling
  • Transcriptional Control

Education and Positions:
  • Ph.D. Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota

Wrestling with SUMO in Cancer


SUMO modification is emerging as an important post-translational control of cellular events. My lab primarily focused on the molecular mechanisms as to how protein sumoylation is regulated and what consequence of a protein is sumoylated in cancer giving that sumoylation levels are elevated in several types of human cancer. We have demonstrated several other modifications such as phosphorylation and acetylation could control protein sumoylation. Since SUMO pathway has been considered as a non-oncogene addiction in cancer, targeting SUMO machinery and/or sumoylated substrates could not only understand the underlying mechanism of sumoylation associated with cancer but also increase the repertoire of druggable targets against cancer. Studies are undergoing to dissect the functional significances of cancer-associated sumoylated factors as well as to develop therapeutic agents in targeting SUMO conjugation and binding in cancer.

Journal 100 Book 0

  1. He Y. Pasupala, N, Zhi H, Dorjbal B, Hussain I, Shih HM, Bhattacharyya S, Biswas R, Semmes OJ, Waldmann TA, Snow AL, and Giam CZ NF-κB-Induced R-loop Accumulation and DNA Damage Select for Nucleotide Excision Repair Deficiencies in Adult T-cell Leukemia PNAS 118(10), e2005568118 (2021-03-09) [JCR] [WOS]
  2. Huang YS, Lu KC, Chao HW, Chen A, Chao TK, Guo CY, Hsieh HY, Shih HM, Sytwu HK, Wu CC The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells. J Cell Physiol 236(3), 2023-2035 (2021-03) [JCR] [WOS]
  3. Hsieh YL, Su FY, Tsai LK, Huang CC, Ko YL, Su LW, Chen KY, Shih HM, Hu CM, Lee WH NPGPx-mediated adaptation to oxidative stress protects motor neurons from degeneration in aging by directly modulating O-GlcNAcase Cell Rep 29(8), 2134-2143.e7 (2019-11) [JCR] [WOS]
  4. Ma HY, Lu CY, Tsao KC, Shih HM, Cheng AL, Huang LM, Chang LY Association of EV71 3C polymorphisms with clinical severity J Microbiol Immunol Infect. 51(5), 608-613 (2018-10) [JCR] [WOS]
  5. Chen SY, Ho CT, Liu WW, Lucanic M, Shih HM, Huang PH, Cheng HJ Regulation of axon repulsion by MAX-1 sumoylation and AP-3 Proc Natl Acad Sci USA 115(35), E8236-E8245 (2018-08) [JCR] [WOS]
  6. Huang YS, Lu KC, Chao TK, Chen JS, Chen A, Guo CY, Hsieh HY, Shih HM, Sytwu HK and Wu CC Role of melatonin receptor 1A and pituitary homeobox-1 coexpression in protecting tubular epithelial cells in membranous nephropathy J Pineal Res 65(1), e12482 (2018-08) [JCR] [WOS]
  7. Hu LY, Chang CC, Huang YS, Chou WC, Lin YM, Ho CC, Chen WT, Shih HM, Hsiung CN, Wu PE, and Shen CY Sumoylation of XRCC1 activated by poly)ADP-ribosyl)ation regulates DNA repair Hum Mol Genet. 27(13), 2306-2317 (2018-07) [JCR] [WOS]
  8. Chang CC, Huang YS, Lin YM, Lin CJ, Jeng JC, Liu SM, Ho TL, Chang RT, Changou C, Ho CC, Shih HM* The role of sentrin-specific protease 2 substrate recognition in TGF-b-induced tumorigenesis Scientific Reports 8(1), 9786 (2018-06) [JCR] [WOS]
  9. Lin CY, YangST, Shen SC, Hsieh YC, Hsu FT, Chen CY, Chiang YH, Chuang JY, Chen KY, Hsu TI, Leong WC, Su YK, Lo WL, Yeh YS, Patria YN, Shih HM, Chang CC and Chou SY Serum amyloid A1 in combination with integrin V3 increases glioblastoma cells mobility and progression Mol Oncol. 12(5), 756-771 (2018-05) [JCR] [WOS]
  10. Cheng CW, Chang CC, Patria YN, Chang RT, Liu YR, Li FA, Shih HM, Lin CY Sex hormone-binding globulin (SHBG) is a potential early diagnostic biomarker for gastric cancer Cancer Medicine 7(1), 64-74 (2018-01) [JCR] [WOS]