顏裕庭博士
退休副研究員
- 02-2789-9061 (Lab) (Room No: N616)
- 02-2652-3941 (Office)
- 02-2785-8847 (Fax)
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Specialty:
- Molecular Genetics
- Cardiovascular Development
- Myofibrillogenesis
Education and Positions:
Ph.D., University of Medicine and Dentistry of New Jersey
本研究室主要探討心肌及骨骼肌細胞臟相之生成和功能之維持，以及維持細胞白質恆定之相關疾病的發生機制。我們建立相關基因改造小鼠為人類疾病模型，用以探討人類相關疾病生成機制，並用以研發、檢測適當之疾病治療方法。目前主要研究方向專注於: (一)胚胎心肌細胞之生成發育: 我們專注於胚胎時期心肌前趨細胞之生成來源、分化以及塑型調節的分子機制之探討。其中熱休克蛋白HSPB7在胚胎發育過程中，對心肌細胞心肌肌小節生成之生化、生理功能的探討。(二)HSPB7對心肌細胞細絲蛋白C（FLNC）之生理功能、生化結構穩定之維持。多種不同的FLNC基因變異與數種心臟和肌肉疾病症狀有關，如肌原纖維肌病（MFM)，心臟肥厚性病變，擴張型心肌病（HCM和DCM）和心律不整心肌病(ACM)。我們先前發現小鼠失去HSPB7基因造成FLNC在心臟或橫膈膜大量表現、沉積，並導致心臟肌肉傳導缺陷而心律不整或橫膈膜結構缺陷而呼吸衰竭致死，顯現出HSPB7對FLNC蛋白質表現和其功能恆定之維持之需要，以及對於FLNC相關遺傳疾病的治療可能扮演一個重要角色。目前實驗室研究是以基因治療於小鼠相關疾病模型，以檢測用予人類疾病治療之可能性。
Our Team
期刊 37
專書 0
期刊 37 專書 0
- Cheng YY, Gregorich Z, Prajnamitra RP, Lundy DJ, Ma TY, Huang YH, Lee YC, Rua SC, Lin JH, Lin PJ, Wen Kuo C, Chen P, Yan YT, Tian R, Kamp TJ, Hsieh PCH. Metabolic Changes Associated With Cardiomyocyte Dedifferentiation Enable Adult Mammalian Cardiac Regeneration. Circulation 146, 1950–1967 (2022-11-24) [JCR] [WOS]
- Chen WJ, Lin IH, Lee CW, Yoshioka K, Ono Y, Yan YT, Yen Y, Chen YF. Ribonucleotide reductase M2B in the myofibers modulates stem cell fate in skeletal muscle. NPJ Regen Med. 7(1), 31 (2022-07-29) [JCR] [WOS]
- Fang PH, Lai YY, Chen CL, Wang HY, Chang YN, Lin YC, Yan YT, Lai CH, Cheng B. Cobalt protoporphyrin promotes human keratinocyte migration under hyperglycemic conditions. Mol Med. 28(1), 71 (2022-06-23) [JCR] [WOS]
- Chen Shih-Yun, Lu Kuan-Ming, Ko Hsin-An, Huang Ting-Hao, Hao Janice Hsin-Jou, Yan Yu-Ting, Chang Sunny Li-Yun, Evans Sylvia M., Liu Fu-Chin Parcellation of the striatal complex into dorsal and ventral districts Proceedings of the National Academy of Sciences 117(13), 7418-7429 (2020-03) [JCR] [WOS]
- Yeh CH, Shen ZQ, Hsiung SY, Wu PC, Teng YC, Chou YJ, Fang SW, Chen CF, Yan YT, Kao LS3,5, Kao CH8, Tsai . Cisd2 is essential to delaying Cisd2 is essential to delaying cardiac aging and to maintaining heart functions. PLoS Biology 17(10) (2019-10) [JCR] [WOS]
- Yuan‐Yuan Cheng, Yu‐Ting Yan, David J Lundy, Annie HA Lo2, Yu‐Ping Wang, Shu‐Chian Ruan, Po‐Ju Lin and Patrick CH Hsieh Reprogramming‐derived gene cocktail increases cardiomyocyte proliferation for heart regeneration EMBO Molecular Medicine 9(2), 251-26 (2017-02) [JCR] [WOS]
- Liao WC, Juo LY, Shih YL, Chen YH, Yan YT HSPB7 prevents cardiac conduction system defect through maintaining intercalated disc integrity. PLoS genetics 13(8), e1006984 (2017) [JCR] [WOS]
- Lee CC, Peng SH, Shen L, Lee CF, Du TH, Kang ML, Xu GL, Upadhyay AK, Cheng X, Yan YT, Zhang Y, Juan LJ The Role of N-alpha-acetyltransferase 10 Protein in DNA Methylation and Genomic Imprinting. Molecular cell 68(1), 89-103.e7 (2017) [JCR] [WOS]
- Juo LY, Liao WC, Shih YL, Yang BY, Liu AB, Yan YT HSPB7 interacts with dimerized FLNC and its absence results in progressive myopathy in skeletal muscles. Journal of cell science 129(8), 1661-1670 (2016) [JCR] [WOS]
- Chen CY, Lee DS, Yan YT, Shen CN, Hwang SM, Lee ST, Hsieh PC Bcl3 Bridges LIF-STAT3 to Oct4 Signaling in the Maintenance of Naive Pluripotency. STEM CELLS 33(12), 3468-3480 (2015) [JCR] [WOS]