Dr. Yan, Yu-Ting 's publons link picture

Dr. Yan, Yu-Ting

Emeritus Associate Research Fellow
  • 02-2789-9061 (Lab) (Room No: N616)
  • 02-2652-3941 (Office)
  • 02-2785-8847 (Fax)

  • Molecular Genetics
  • Cardiovascular Development 
  • Myofibrillogenesis

Education and Positions:
  • Ph.D., University of Medicine and Dentistry of New Jersey

The studies of Yan's laboratory are on the convergence of genetic and biochemical pathways to maintain the proteostasis in striated muscle and neural tissues. Proteostasis is referred to the biochemical network allowing for cellular proteins to maintain a proper biological activity according to the cell environment. It is mainly controlled by protein quality control (PQC) system. Disruption of PQC system will cause the derailment of cellular protein homeostasis and lead to the occurrence of diseases. The PQC is crucial for cardiac and neural health and requires the collaboration of all its components to be functional. It is composed of three systems including chaperone proteins, the ubiquitin-proteasome system (UPS), and autophagy. We currently focus on elucidating the molecular mechanism of small heart shock protein B7 (HSPB7) at maintaining the proteostasis in cardiac, muscular and neural health and possible therapeutical role at related diseases. At our recent studies, we showed that small heat shock protein B7 is required for maintaining FLNC location and normal function in muscle cells. Loss of HSPB7 causes overexpression and aggregation of FLNC in skeletal muscle. We also found that the expression of FLNC and HSPB7 is tightly associated with each other during muscle regeneration in mouse. In addition, HSPB7 interacts with dimerized FLNC in cell culture system. Put together, we propose the hypothesis that HSPB7 can play a role to facilitate the cell mechanosensor function by stabilizing structure of FLNC to maintain the muscle homeostasis. 

Our Team
Team photo

Journal 37 Book 0

  1. Cheng YY, Gregorich Z, Prajnamitra RP, Lundy DJ, Ma TY, Huang YH, Lee YC, Rua SC, Lin JH, Lin PJ, Wen Kuo C, Chen P, Yan YT, Tian R, Kamp TJ, Hsieh PCH. Metabolic Changes Associated With Cardiomyocyte Dedifferentiation Enable Adult Mammalian Cardiac Regeneration. Circulation 146, 1950–1967 (2022-11-24) [JCR] [WOS]
  2. Chen WJ, Lin IH, Lee CW, Yoshioka K, Ono Y, Yan YT, Yen Y, Chen YF. Ribonucleotide reductase M2B in the myofibers modulates stem cell fate in skeletal muscle. NPJ Regen Med. 7(1), 31 (2022-07-29) [JCR] [WOS]
  3. Fang PH, Lai YY, Chen CL, Wang HY, Chang YN, Lin YC, Yan YT, Lai CH, Cheng B. Cobalt protoporphyrin promotes human keratinocyte migration under hyperglycemic conditions. Mol Med. 28(1), 71 (2022-06-23) [JCR] [WOS]
  4. Chen Shih-Yun, Lu Kuan-Ming, Ko Hsin-An, Huang Ting-Hao, Hao Janice Hsin-Jou, Yan Yu-Ting, Chang Sunny Li-Yun, Evans Sylvia M., Liu Fu-Chin Parcellation of the striatal complex into dorsal and ventral districts Proceedings of the National Academy of Sciences 117(13), 7418-7429 (2020-03) [JCR] [WOS]
  5. Yeh CH, Shen ZQ, Hsiung SY, Wu PC, Teng YC, Chou YJ, Fang SW, Chen CF, Yan YT, Kao LS3,5, Kao CH8, Tsai . Cisd2 is essential to delaying Cisd2 is essential to delaying cardiac aging and to maintaining heart functions. PLoS Biology 17(10) (2019-10) [JCR] [WOS]
  6. Yuan‐Yuan Cheng, Yu‐Ting Yan, David J Lundy, Annie HA Lo2, Yu‐Ping Wang, Shu‐Chian Ruan, Po‐Ju Lin and Patrick CH Hsieh Reprogramming‐derived gene cocktail increases cardiomyocyte proliferation for heart regeneration EMBO Molecular Medicine 9(2), 251-26 (2017-02) [JCR] [WOS]
  7. Liao WC, Juo LY, Shih YL, Chen YH, Yan YT HSPB7 prevents cardiac conduction system defect through maintaining intercalated disc integrity. PLoS genetics 13(8), e1006984 (2017) [JCR] [WOS]
  8. Lee CC, Peng SH, Shen L, Lee CF, Du TH, Kang ML, Xu GL, Upadhyay AK, Cheng X, Yan YT, Zhang Y, Juan LJ The Role of N-alpha-acetyltransferase 10 Protein in DNA Methylation and Genomic Imprinting. Molecular cell 68(1), 89-103.e7 (2017) [JCR] [WOS]
  9. Juo LY, Liao WC, Shih YL, Yang BY, Liu AB, Yan YT HSPB7 interacts with dimerized FLNC and its absence results in progressive myopathy in skeletal muscles. Journal of cell science 129(8), 1661-1670 (2016) [JCR] [WOS]
  10. Chen CY, Lee DS, Yan YT, Shen CN, Hwang SM, Lee ST, Hsieh PC Bcl3 Bridges LIF-STAT3 to Oct4 Signaling in the Maintenance of Naive Pluripotency. STEM CELLS 33(12), 3468-3480 (2015) [JCR] [WOS]