Dr. Liao, Fang 's publons link picture



  • Chemokines
  • Chemokine Receptors

Education and Positions:
  • Ph.D. Johns Hopkins University School of Medicine.

趨化素(Chemokine)是一群可被誘導,可被分泌而且結構類似的小分子(8-14kd)。趨化素可分為CXC、CC、CX3C及C四亞群;若以功能來分類,趨化素可分為恆定性趨化素(Homeostasis chemokines)及發炎性趨化素(Inflammatory chemokines)。趨化素受器(Chemokine receptor)是屬於G-蛋白偶合受器(G-protein coupled receptor; GPCR),主要表現在白血球,趨化素及其受器的主要功能是將白血球吸引到感染或受傷的組織,使白血球能發揮抵抗病原菌的能力並且啟動免疫及發炎反應。本室主要探討趨化素及其受器的生理功能:(1)研究CCR6的生化及生理功能;(2)利用動物模式來探討趨化素及其受器在感染及發炎疾病所扮演的角色。
Our Team
Team photo

期刊 50 專書 1

  1. Ip, P-P., Chung, C-Y., Chang, C-C., Lee, Y-F., Wang, H-M., Lian, I-B., Fann, C-S., Yang, C-C. and Liao, F. Differentiation of remitting neuromyelitis optica spectrum disorders from multiple sclerosis by integrating parameters from serum proteins and lymphocyte subsets JOURNAL OF NEUROIMMUNOLOGY 318, 45-52 (2018-05-15) [JCR] [WOS]
  2. Lu, M-Y., Lu, S-S., Chang, S-L., and Liao, F. The phosphorylation of CCR6 on distinct Ser/Thr residues in the carboxyl terminus differentially regulates biological function. Frontiers in Immunology 9, 415 (2018-03-02) [JCR] [WOS]
  3. Lin Y-L., Ip, P-P. and Liao F. CCR6 deficiency impairs IgA production and dysregulates antimicrobial peptide production, altering the intestinal flora. Frontiers in Immunology 8, 805 (2017-07-11) [JCR] [WOS]
  4. Wang, I-C., Chung, C-Y., Liao, F., Chen, C-C and Lee, C-H. Peripheral sensory neuron injury contributes to neuropathic pain in experimental autoimmune encephalomyelitis. Sci. Rep. 7: 42304. SCIENTIFIC REPORTS 7, 42304 (2017-02-09) [JCR] [WOS]
  5. Chung CY, Liao F* CXCR3 signaling in glial cells ameliorates experimental autoimmune encephalomyelitis by restraining the generation of a pro-Th17 cytokine milieu and reducing CNS-infiltrating Th17 cells. Journal of Neuroinflammation 13(1), 76 (2016-04) [JCR] [WOS]
  6. Singh SP, Foley JF, Zhang HH, Hurt DE, Richards JL, Smith CS, Liao F, Farber JM. Selectivity in the use of Gi/o proteins is determined by the DRF motif in CXCR6 and is cell-type specific. Molecular Pharmacology 88, 894-910 (2015) [JCR] [WOS]
  7. Liao F, Hsu YC, Kuo SH, Yang YC, Chen JP, Hsu PN, Lin CW, Chen LT, Cheng AL, Fann CS, Lin JT, Wu MS Genetic polymorphisms and tissue expression of interleukin-22 associated with risk and therapeutic response of gastric mucosa-associated lymphoid tissue lymphoma Blood Cancer Journal 4, eXX (2014-10) [JCR] [WOS]
  8. Chen HL, Liao, F, Lin TN, Liu FT Galectins and Neuroinflammation Advances in Neurobiology 9, 517-542 (2014) [JCR] [WOS]
  9. Chen JP, Wu MS, Kuo SH, and Liao F IL-22 negatively regulates Helicobacter pylori-induced CCL20 expression in gastric epithelial cells PLoS One 9, e97350 (2014) [JCR] [WOS]
  10. Chiang YJ, Ho KC, Sun CT, Chiu JJ, Lee FJ, Liao F, Yang-Yen HF, and Yen JJ. CBAP functions as a novel component in Chemokine-induced ZAP70-mediated T-cell adhesion and migration. PLoS One 8(4), e61761 (2013) [JCR] [WOS]

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