Dr. Liao, Fang 's publons link picture

Dr. Liao, Fang

Emeritus Research Fellow

  • Chemokines
  • Chemokine Receptors

Education and Positions:
  • Ph.D. Johns Hopkins University School of Medicine.

Chemokines are a family of more than forty small, secreted proteins. Chemokines have been divided into CXC, CC, C and CX3C subfamilies. Functionally, chemokines can be divided into homeostatic and inflammatory; homeostatic chemokines play critical roles in lymphoid organogenesis and homeostasis, while inflammatory chemokines are involved in inflammatory responses. Chemokines target cells through receptors that are members of the seven transmembrane domain G protein-coupled receptor superfamily. My research focuses on understanding the chemokines and their receptors from the perspectives of biochemistry and immunology. There are two principal research interests in my laboratory: (1) dissecting the signaling pathway used by the CCR6 receptor and investigating how CCR6 traffics within the cell in response to activation by chemokine agonist; (2) investigating the biology of chemokines/chemokine receptors in inflammatory and infectious diseases using gene-targeted mice, such as the biological functions of chemokines/chemokine receptors in virus infection and the biological roles of CCR6 and CXCR3 in inflammatory diseases.
Our Team
Team photo

Journal 47 Book 1

  1. Ip, P-P., Chung, C-Y., Chang, C-C., Lee, Y-F., Wang, H-M., Lian, I-B., Fann, C-S., Yang, C-C. and Liao, F. Differentiation of remitting neuromyelitis optica spectrum disorders from multiple sclerosis by integrating parameters from serum proteins and lymphocyte subsets JOURNAL OF NEUROIMMUNOLOGY 318, 45-52 (2018-05-15) [JCR] [WOS]
  2. Lu, M-Y., Lu, S-S., Chang, S-L., and Liao, F. The phosphorylation of CCR6 on distinct Ser/Thr residues in the carboxyl terminus differentially regulates biological function. Frontiers in Immunology 9, 415 (2018-03-02) [JCR] [WOS]
  3. Lin Y-L., Ip, P-P. and Liao F. CCR6 deficiency impairs IgA production and dysregulates antimicrobial peptide production, altering the intestinal flora. Frontiers in Immunology 8, 805 (2017-07-11) [JCR] [WOS]
  4. Wang, I-C., Chung, C-Y., Liao, F., Chen, C-C and Lee, C-H. Peripheral sensory neuron injury contributes to neuropathic pain in experimental autoimmune encephalomyelitis. Sci. Rep. 7: 42304. SCIENTIFIC REPORTS 7, 42304 (2017-02-09) [JCR] [WOS]
  5. Chung CY, Liao F* CXCR3 signaling in glial cells ameliorates experimental autoimmune encephalomyelitis by restraining the generation of a pro-Th17 cytokine milieu and reducing CNS-infiltrating Th17 cells. Journal of Neuroinflammation 13(1), 76 (2016-04) [JCR] [WOS]
  6. Singh SP, Foley JF, Zhang HH, Hurt DE, Richards JL, Smith CS, Liao F, Farber JM. Selectivity in the use of Gi/o proteins is determined by the DRF motif in CXCR6 and is cell-type specific. Molecular Pharmacology 88, 894-910 (2015) [JCR] [WOS]
  7. Liao F, Hsu YC, Kuo SH, Yang YC, Chen JP, Hsu PN, Lin CW, Chen LT, Cheng AL, Fann CS, Lin JT, Wu MS Genetic polymorphisms and tissue expression of interleukin-22 associated with risk and therapeutic response of gastric mucosa-associated lymphoid tissue lymphoma Blood Cancer Journal 4, eXX (2014-10) [JCR] [WOS]
  8. Chen HL, Liao, F, Lin TN, Liu FT Galectins and Neuroinflammation Advances in Neurobiology 9, 517-542 (2014) [JCR] [WOS]
  9. Chen JP, Wu MS, Kuo SH, and Liao F IL-22 negatively regulates Helicobacter pylori-induced CCL20 expression in gastric epithelial cells PLoS One 9, e97350 (2014) [JCR] [WOS]
  10. Chiang YJ, Ho KC, Sun CT, Chiu JJ, Lee FJ, Liao F, Yang-Yen HF, and Yen JJ. CBAP functions as a novel component in Chemokine-induced ZAP70-mediated T-cell adhesion and migration. PLoS One 8(4), e61761 (2013) [JCR] [WOS]

Chuang, Jifen
Ip, Peng Peng
Kuo, Alicia
Lin, Yalin