趙麗洋博士
退休研究員
Specialty:
- Cardiovascular/Cancer Disease
- Inflammation
Education and Positions:
Ph.D. University of Kentucky
本實驗室的研究主要為探討第一型血紅素氧化脢 (HO-1)在發炎相關之心血管疾病和癌症中之角色 . 許多的研究証實HO-1可藉由其分解細胞內血紅素所釋放出來的具有抗發炎和抗氧化之產物, 一氧化碳和膽紅素, 而保謢細胞. 雖然HO-1可藉由多重途徑達到保謢心血管之作用, 但HO-1卻可促進癌細胞的生長和轉移. 我們最近的研究發現抑癌基因蛋白TRC8可藉由促進HO-1的泛素化和分解而達到抑制癌細胞生長之作用 . 此外我們亦發現HO-1 可經由蛋白裂解脢之作用，而離開內質網，進入細胞核而促進癌細胞的生長卻不須要依賴其酵素活性. 目前我們將進一步探討其可能的分子机制. 並對白血球中HO-1 之表現是否影響和癌症相關之發炎反應並癌細胞的轉移作深入探討 .
Our Team
期刊 63
專書 0
期刊 63 專書 0
- Chiang MT, Chen IM, Hsu FF, Chen YH, Tsai MS, Hsu YW, Leu HB, Huang PH, Chen JW, Liu FT, Chen YH, Chau LY* Galectin-1 upregulation contributes to abdominal aortic aneurysm progression by enhancing vascular inflammation. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 41(1), 331-345 (2021) [JCR] [WOS]
- Hsu YW, Hsu FF, Chiang MT, Tsai DL, Li FA, Angata T, Crocker PR, Chau LY*. Siglec-E retards atherosclerosis by inhibiting CD36-mediated foam cell formation.. J Biomed Sci. 28(1), 5 (2021) [JCR] [WOS]
- Fu-Fei Hsu, Yi-Tai Chou, Ming-Tsai Chiang, Fu-An Li, Chi-Tai Yeh, Wei-Hwa Lee and (Lee-Young Chau*) Signal peptide peptidase promotes tumor progression via facilitating FKBP8 degradation. ONCOGENE 38(10),1688-1701 (2019-03) [JCR] [WOS]
- Min-Shao Tsai, Ming-Tsai Chiang, Dong-Lin Tsai, Chih-Wen Yang, Hsien-San Hou, Yi-Ru Li, Po-Chiao Chang, Heng-Huei Lin, Huan-Yuan Chen, Ing-Shouh Hwang, Pei-Kuen Wei, Chiao-Po Hsu, Kuo-I Lin, Fu-Tong Liu, (Lee-Young Chau*) Galectin-1 Restricts Vascular Smooth Muscle Cell Motility Via Modulating Adhesion Force and Focal Adhesion Dynamics. SCIENTIFIC REPORTS 8(1), 11497 (2018-07-31) [JCR] [WOS]
- Yi-Tai Chou, Fu-Fei Hsu, Dun-Yao Hu, Ying-Chih Chen, Yuan-Hao Hsu, John T.-A. Hsu and (Lee-Young Chau*) Identification of danthron as an isoform-specific inhibitor of HEME OXYGENASE-1/cytochrome P450 reductase interaction with anti-tumor activity. JOURNAL OF BIOMEDICAL SCIENCE 25(1), 6 (2018-01-23) [JCR] [WOS]
- Hsu FF, Chiang MT, Li FA, Yeh CT, Lee WH, [Chau LY] Acetylation is essential for nuclear heme oxygenase-1-enhanced tumor growth and invasiveness. ONCOGENE 36(49), 6805-6814 (2017-08) [JCR] [WOS]
- Cheng B, Toh EKW, Chen KH, ChangYC, Hu CMJ, Wu HC,( Chau LY), Chen PL, Hsieh PCH* Biomimicking Platelet-Monocyte Interactions as a Novel Targeting Strategy for Heart Healing. . Advanced Healthcare Materials 5(20), 2686-2697 (2016-10) [JCR] [WOS]
- Lin HH, Chiang MT, Chang PC, Chau LY Myeloid heme oxygenase-1 promotes metastatic tumor colonization in mice. Cancer science 106(3), 299-306 (2015-03) [JCR] [WOS]
- Chau LY Heme oxygenase-1: emerging target of cancer therapy.. Journal of Biomedical Science 22(1), 22 (2015) [JCR] [WOS]
- Chang PC, Tsai HW, Chiang MT, Huang PL, Shyue SK, Chau LY TRC8 downregulation contributes to the development of non-alcoholic steatohepatitis by exacerbating hepatic endoplasmic reticulum stress.. Biochimica et Biophysica Acta-Molecular Basis of Disease 1852(11), 2339-2351 (2015) [JCR] [WOS]