Ph.D. University of Kentucky
My group is interested in investigating the functional role of heme oxygenase-1 (HO-1), which is an ER-anchored enzyme catalyzing the oxidative degradation of cellular heme to free iron, carbon monoxide (CO), and biliverdin, in inflammation-associated diseases, including cardiovascular diseases and cancer. Compelling evidence has demonstrated that HO-1 exerts potent anti-inflammatory and antioxidant effects via the action of CO and biliverdin, respectively. Although HO-1 provides multiprotective functions in cardiovascular system, HO-1 promotes tumorigenesis in cancer. We recently identified the tumor suppressor TRC8 is an E3 ligase mediating the ubiquitination and degradation of HO-1. We also found that HO-1 is susceptible to the intramembrane cleavage by an ER-resident peptidase and translocates into nucleus to promote cancer cell proliferation and invasion independent of its enzymatic activity. Studies are currently ongoing to investigate the mechanism underlying the tumorigenic function of nuclear HO-1. Moreover, the role of myeloid HO-1 implicated in cancer-associated inflammation and its impacts on cancer metastasis is also under investigation.
Siglec-E retards atherosclerosis by inhibiting CD36-mediated foam cell formationJournal of Biomedical Science, Jan 05, 2021
Gal-1 (Galectin-1) Upregulation Contributes to Abdominal Aortic Aneurysm Progression by Enhancing Vascular InflammationArteriosclerosis, Thrombosis, and Vascular Biology, Nov 05, 2020