Dr. Yang, Ruey-Bing (Ray)'s publons link picture

楊瑞彬博士

代理所長
研究員
  • (02) 2789-9063 (Lab) (Room No: N427)
  • (02) 2652-3943
  • (02) 2785-8847 (Fax)

Specialty:

Signal transduction

Receptor biology

Vascular biology


Education and Positions:
  • Ph.D., University of Texas Southwestern Medical Center at Dallas

    Postdoctoral Fellow, Genentech, Inc.


       本研究室致力於探討一個分泌性膜蛋白家族--SCUBE (signal peptide-CUB-EGF domain-containing proteins) 於基礎與轉譯醫學上的重要性。此蛋白家族最初發現於內皮細胞中,共包括三個膜蛋白成員分別為SCUBE1、SCUBE2及SCUBE3,其在演化上高度保留,廣泛地存在於人類、小鼠與斑馬魚等脊椎動物體內。SCUBE因其表現於細胞之不同位置展現出其獨特的功能。例如,SCUBE1由活化態血小板分泌至血液中,藉由其具黏附特性之EGF重複序列 (EGF-like repeats) 促使血小板相互聚集與鏈結,為體內動脈血栓 (arterial thrombosis) 形成之重要機制。因此,SCUBE1不僅為急性冠狀動脈症候群 (acute coronary syndrome) 與急性缺血性腦中風 (acute ischemia stroke) 之生物標記,其具黏附特性之結構亦成為抗血栓藥物開發之標的。而當SCUBE蛋白以周膜蛋白 (peripheral membrane protein) 形式表現於細胞表面,其能作為輔受體 (co-receptor) 增強多種生長因子之訊號活性。我們的研究發現,內皮細胞表面之SCUBE2於缺血或缺氧環境中大量表現,並作為VEGFR2之輔受體,增強由VEGF誘發之內皮細胞生長速率與管腔生成 (tube formation),於病理性血管新生 (pathological angiogenesis) 上扮演重要角色。因此,以SCUBE2為標靶或許為治療VEGF誘發之增生性血管病變之嶄新策略。此外,本研究團隊率先發現由SCUBE功能缺陷引發之發育障礙。來自9個國家彼此無血緣關係之18個個體,其SCUBE3基因產生雙等位基因失活變異體 (bi-allelic inactivating variants),此變異體導致多重發育障礙綜合症,包括生長遲緩、骨骼異常、牙齒不規則排列並具有獨特的顱面外觀。未來,我們將通過與心血管醫學領域的醫生科學家合作,藉由基因修飾之小鼠模式以及由轉譯醫學的角度,持續深入探究SCUBE蛋白之生物功能。

期刊 87 專書 0

  1. 3.Udesh Dhawan, Wei-Li Wang, Yuh-Charn Lin, Ruey-Bing Yang, Matthew J. Dalby, Manuel Salmeron-Sanchez, Hsiao-Hua Yu Mechanostimulation-induced integrin αvβ6 and Latency Associated Peptide coupling activates TGF-β and regulates cancer metastasis and stemness NANO TODAY 50, 101882 (2023) [JCR] [WOS]
  2. Yang CW, Hsu HY, Lee YZ, Jan JT, Chang SY, Lin YL, Yang RB, Chao TL, Liang JJ, Lin SJ, Liao CC, Chang CS, Sytwu HK, Hung MS, Chen CT, Lee SJ Natural fucoidans inhibit coronaviruses by targeting viral spike protein and host cell furin. Biochemical pharmacology 215, 115688 (2023) [JCR] [WOS]
  3. Tsai MT, Yang RB, Ou SM, Tseng WC, Lee KH, Yang CY, Chang FP, Tarng DC Plasma Galectin-9 Is a Useful Biomarker for Predicting Renal Function in Patients Undergoing Native Kidney Biopsy. Archives of pathology & laboratory medicine 147(2), 167-176 (2023) [JCR] [WOS]
  4. Sahoo BK, Lin YC, Tu CF, Lin CC, Liao WJ, Li FA, Li LH, Mou KY, Roffler SR, Wang SP, Yeh CT, Yao CY, Hou HA, Chou WC, Tien HF, Yang RB Signal peptide-CUB-EGF-like repeat-containing protein 1-promoted FLT3 signaling is critical for the initiation and maintenance of MLL-rearranged acute leukemia. Haematologica 108(5), 1284-1299 (2023) [JCR] [WOS]
  5. Lou YC, Tu CF, Chou CC, Yeh HH, Chien CY, Sadotra S, Chen C, Yang RB, Hsu CH Structural insights into the role of N-terminal integrity in PhoSL for core-fucosylated N-glycan recognition. International journal of biological macromolecules 255, 128309 (2023) [JCR] [WOS]
  6. Lin YC, Sahoo BK, Gau SS, Yang RB The biology of SCUBE. Journal of biomedical science 30(1), 33 (2023) [JCR] [WOS]
  7. Hu YF, Lee AS, Chang SL, Lin SF, Weng CH, Lo HY, Chou PC, Tsai YN, Sung YL, Chen CC, Yang RB, Lin YC, Kuo TBJ, Wu CH, Liu JD, Chung TW, Chen SA Biomaterial-induced conversion of quiescent cardiomyocytes into pacemaker cells in rats. Nature biomedical engineering 6(4), 421-434 (2022) [JCR] [WOS]
  8. Tamang HK, Yang RB, Song ZH, Hsu SC, Peng CC, Tung YC, Tzeng BH, Chen CC Ca(v) 3.2 T-type calcium channel regulates mouse platelet activation and arterial thrombosis. Journal of thrombosis and haemostasis : JTH 20(8), 1887-1899 (2022) [JCR] [WOS]
  9. Prajnamitra RP, Cheng YY, Beh CY, Lu CY, Lin JH, Ruan SC, Chen SL, Chen HC, Yang RB, Hsieh PC Depletion of gut microbiota improves the therapeutic efficacy of cancer nanomedicine. Theranostics 12(17), 7390-7403 (2022) [JCR] [WOS]
  10. Chou PC, Liu CM, Weng CH, Yang KC, Cheng ML, Lin YC, Yang RB, Shyu BC, Shyue SK, Liu JD, Chen SP, Hsiao M, Hu YF Fibroblasts Drive Metabolic Reprogramming in Pacemaker Cardiomyocytes. Circulation research 131(1), 6-20 (2022) [JCR] [WOS]

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凃瀞芬
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林育嬋
- 研究助理 -
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高祥薪
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林憶雯
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蔡政達
- 學生 -
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陳奕廷
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蕭艾琳
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張庭瑜
CHUNG, PEI CHEN
鍾北辰
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吳亭吟
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羅凱
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曹古驥
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趙英淇
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沙比內
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楊欣瑜