Dr. Yang, Ruey-Bing (Ray)
Acting Director
Research Fellow
- (02) 2789-9063 (Lab) (Room No: N427)
- (02) 2652-3943
- (02) 2785-8847 (Fax)
-
Specialty:
Signal transduction
Receptor biology
Vascular biology
Education and Positions:
Ph.D., University of Texas Southwestern Medical Center at Dallas
Postdoctoral Fellow, Genentech, Inc.
This laboratory is interested in understanding the basic and translational biology of a secreted and membrane SCUBE (signal peptide-CUB-EGF domain-containing protein) family originally identified from endothelial cells (ECs). Three different members (SCUBE1 to 3) have been identified and appear to be evolutionarily conserved in vertebrates from zebrafish and mice to humans. We showed that SCUBEs are multi-functional proteins depending on their subcellular localization and distribution. For example, plasma SCUBE1 released from activated platelets not only serves as a biomarker for acute coronary syndrome and acute ischemic stroke also actively participates in arterial thrombosis via its adhesive EGF-like repeats in vivo, suggesting that these adhesive motifs of SCUBE1 might serve as potential anti-thrombotic targets. However, when these SCUBEs expressed as peripheral membrane proteins tethered on the cell surface, they can function as co-receptor in promoting signal activity of various growth factors. We demonstrated that EC SCUBE2 acting as a co-receptor for vascular endothelial growth factor receptor 2 (VEGFR2) regulate VEGF-induced tube formation and proliferation of ECs: it fine-tunes VEGFR2-mediated signaling during postnatal angiogenesis induced by ischemia or during pathological angiogenesis under hypoxic conditions. Together, our studies suggest that targeting SCUBE2 on modulating VEGF signaling might provide potential therapeutic treatment for VEGF-mediated proliferative pathological vascular diseases. Most interestingly, we identified that bi-allelic inactivating variants in SCUBE3 have pleiotropic consequences on development and cause a previously unrecognized syndromic disorder. Eighteen affected individuals from nine unrelated families showed a consistent phenotype characterized by reduced growth, skeletal features, distinctive craniofacial appearance, and dental anomalies. In the future, we will continue to explore their in-depth fundamental biology by the use of genetically-modified mouse models as well as elucidate their translational implications through collaboration with physician scientists in the field of cardiovascular medicine.
- Tamang HK, Yang RB, Song ZH, Hsu SC, Peng CC, Tung YC, Tzeng BH, Chen CC Cav 3.2 T-type calcium channel regulates mouse platelet activation and arterial thrombosis. Journal of thrombosis and haemostasis : JTH (2022) [JCR] [WOS]
- Tsai MT, Yang RB, Ou SM, Tseng WC, Lee KH, Yang CY, Chang FP, Tarng DC Plasma Galectin-9 Is a Useful Biomarker for Predicting Renal Function in Patients Undergoing Native Kidney Biopsy. Archives of pathology & laboratory medicine 147(2) , 167-176 (2022) [JCR] [WOS]
- Sahoo BK, Lin YC, Tu CF, Lin CC, Liao WJ, Li FA, Li LH, Mou KY, Roffler SR, Wang SP, Yeh CT, Yao CY, Hou HA, Chou WC, Tien HF, Yang RB Signal peptide-CUB-EGF-like repeat-containing protein 1-promoted FLT3 signaling is critical for the initiation and maintenance of MLL-rearranged acute leukemia. Haematologica (2022) [JCR] [WOS]
- Prajnamitra RP, Cheng YY, Beh CY, Lu CY, Lin JH, Ruan SC, Chen SL, Chen HC, Yang RB, Hsieh PC Depletion of gut microbiota improves the therapeutic efficacy of cancer nanomedicine. Theranostics 12(17), 7390-7403 (2022) [JCR] [WOS]
- Chou PC, Liu CM, Weng CH, Yang KC, Cheng ML, Lin YC, Yang RB, Shyu BC, Shyue SK, Liu JD, Chen SP, Hsiao M, Hu YF Fibroblasts Drive Metabolic Reprogramming in Pacemaker Cardiomyocytes. Circulation research 131(1), 6-20 (2022) [JCR] [WOS]
- Liu Y, Guerrero-Juarez CF, Xiao F, Shettigar NU, Ramos R, Kuan CH, Lin YC, de Jesus Martinez Lomeli L, Park JM, Oh JW, Liu R, Lin SJ, Tartaglia M, Yang RB, Yu Z, Nie Q, Li J, Plikus MV Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state. Developmental cell 57(14), 1758-1775.e7 (2022) [JCR] [WOS]
- Tu CF, Li FA, Li LH, Yang RB Quantitative glycoproteomics analysis identifies novel FUT8 targets and signaling networks critical for breast cancer cell invasiveness. Breast cancer research : BCR 24(1), 21 (2022) [JCR] [WOS]
- Lee YZ, Hsu HY, Yang CW, Lin YL, Chang SY, Yang RB, Liang JJ, Chao TL, Liao CC, Kao HC, Chang JY, Sytwu HK, Chen CT, Lee SJ The Synergistic Inhibition of Coronavirus Replication and Induced Cytokine Production by Ciclesonide and the Tylophorine-Based Compound Dbq33b. Pharmaceutics 14(7), 1511 (2022) [JCR] [WOS]
- Ou SM, Tsai MT, Chen HY, Li FA, Lee KH, Tseng WC, Chang FP, Lin YP, Yang RB, Tarng DC Urinary Galectin-3 as a Novel Biomarker for the Prediction of Renal Fibrosis and Kidney Disease Progression. Biomedicines 10(3), 585 (2022) [JCR] [WOS]
- Huang YL, Huang MT, Sung PS, Chou TY, Yang RB, Yang AS, Yu CM, Hsu YW, Chang WC, Hsieh SL Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection. Communications biology 4(1), 229 (2021) [JCR] [WOS]
POSTDOC
Tu, Cheng Fen
Lin, Yuh Charn
RESEARCH ASSOCIATES
Gau, Shiang-Shin
Lin, Yi-Wen
Chien, Kai-Ting
STUDENTS
CHEN, YI TING
ALUMNI
Wu, Meng Ying
Hsiao, Ai Lin
Chang, Ting Yu
CHUNG, PEI CHEN
Wu, Ting-Yin
Rao, Vaikar Navakanth
Tsao, Ku Chi
Chao, Ying Chi
Sahoo, Binay K.
Liao, Wei Ju
