Dr. Chen, Chih-Cheng 's publons link picture

陳志成博士

副所長
特聘研究員
  • 02-2652-3917
  • 02-2782-9224 (Fax)
Specialty:
  • Pain
  • Neurosensory Mechanotransduction
Education and Positions:

  • Ph.D. University College London, UK

酸是造成疼痛的主要因子之一，特別是發炎，缺血，腫瘤等引起的慢性疼痛均與組織酸化有關。因此，研究傳遞酸訊息的基因將有助於發展新的止痛對策與藥物。我們過去已經從痛覺神經中陸續選殖出酸的受體基因，並建立了多種酸敏性離子通道的基因剔除小鼠模式。目前主要的研究方向包含:

(1) 探討引起慢性肌肉酸痛的分子機制。

(2) 研究酸敏性離子通道在神經傳導與生理恆定所扮演的角色。

(3) 選殖機械力受體的基因並探討其在慢性酸痛所扮演的角色。

Our Team
Team photo

期刊 97 專書 3

  1. Hung CH, Chin Y, Fong YO, Lee CH, Han DS, Lin JH, Sun WH, (Chen CC)* Acidosis-related pain and its receptors as targets for chronic pain. Pharmacology & therapeutics 247, 108444 (2023) [JCR] [WOS]
  2. Wu CH, Chou WH, Long YH, Yang HH, Lin T, Yang CC, Sun WZ, (Chen CC), Lin CP Development of the Chronic Pain Cognition Scale: A Culture-Sensitive Pain Measurement in Chinese. Journal of pain research 16, 3075-3084 (2023) [JCR] [WOS]
  3. Lin YC, Lee CH, Sung JY, (Chen CC)* Genetic exploration of roles of acid-sensing ion channel subtypes in neurosensory mechanotransduction including proprioception. Experimental physiology doi: 10.1113/EP090762, doi: 10.1113/EP090762 (2023) [JCR] [WOS]
  4. Han DS, Lee CH, Shieh YD, Chang KV, Lin SH, Chu YC, Wang JL, (Chen CC)* Involvement of ASIC3 and Substance P in Therapeutic Ultrasound-Mediated Analgesia in Mouse Models of Fibromyalgia. The journal of pain 24(8), 1493-1505 (2023) [JCR] [WOS]
  5. Lee HH, (Chen CC)* Myalgia! Where does it come from? Acta neurologica Taiwanica 32(4), 230-239 (2023) [JCR] [WOS]
  6. Yang CT, Guan Y, (Chen CC), Lin WT, Lu KH, Lin CR, Shyu BC, Wen YR Novel Pulsed Ultrahigh-frequency Spinal Cord Stimulation Inhibits Mechanical Hypersensitivity and Brain Neuronal Activity in Rats after Nerve Injury. Anesthesiology 139(5), 646-663 (2023) [JCR] [WOS]
  7. Hung CH, Tsai MH, Wang PS, Liang FW, Hsu CY, Lee KW, Fong YO, Han DS, Lee CH, Lai CL, (Chen CC)* Oxidative stress involves phenotype modulation of morbid soreness symptoms in fibromyalgia. RMD open 9(1), e002741 (2023) [JCR] [WOS]
  8. Cheng YR, Chi CH, Lee CH, Lin SH, Min MY, (Chen CC)* Probing the Effect of Acidosis on Tether-Mode Mechanotransduction of Proprioceptors. International journal of molecular sciences 24(16), 12783 (2023) [JCR] [WOS]
  9. Lee CH, Chen CC Role of proprioceptors in chronic musculoskeletal pain. Experimental physiology doi: 10.1113/EP090989, doi: 10.1113/EP090989 (2023) [JCR] [WOS]
  10. Chiu HY, Su IW, Yu YW, Chen YC, (Chen CC), Lin JH Soreness or sng: a common symptom with differential clinical impact from pain in degenerative lumbar spine diseases. BMJ open quality 12(1), e001982 (2023) [JCR] [WOS]
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