Dr. Chen, Chih-Cheng 's publons link picture

Dr. Chen, Chih-Cheng

Deputy Director
Distinguished Research Fellow
  • 02-2652-3917
  • 02-2782-9224 (Fax)

  • Pain
  • Neurosensory Mechanotransduction

Education and Positions:
  • Ph.D. University College London, UK

Our research interest is molecular nociception, which is to understand the molecular mechanism and genetic control of pain sensation.

One of our major interests is in pain associated with tissue acidosis. Muscle pain is our current focus. The long-range goal is to understand and control the intractable chronic widespread pain, such as fibromyalgia, myofascial pain syndromes, etc.

The second major interest is related to the physiological and pathological roles of acid signaling. Due to the fact that tissue acidosis does not always cause pain, we notice that acid signaling may participate in neurotransmission and trigger biofeedback to modulate physiological homeostasis. Acid-sensing ion channels (ASICs)  are the major acid sensors in mammals. We are using genetic approaches to reveal the roles of ASICs in physiological homeostasis and neural modulation.

The third major interest is to probe the molecular identity and electrophysiological properties of stretch-activated ion channels that are responsible for neurosensory mechanotransduction. We aim to know the roles of the stretch-activated ion channels in chronic acid pain.

Our Team
Team photo

  1. Chiu HY, Su IW, Yu YW, Chen YC, (Chen CC), Lin JH Soreness or sng: a common symptom with differential clinical impact from pain in degenerative lumbar spine diseases. BMJ open quality 12(1), e001982 (2023) [JCR] [WOS]
  2. Wu PR, Chiang SY, Midence R, Kao WC, Lai CL, Cheng IC, Chou SJ, (Chen CC), Huang CY, Chen RH Wdr4 promotes cerebellar development and locomotion through Arhgap17-mediated Rac1 activation. Cell death & disease 14(1), 52 (2023) [JCR] [WOS]
  3. Han DS, Lee CH, Shieh YD, Chang CT, Li MH, Chu YC, Wang JL, Chang KV, Lin SH, (Chen CC)* A role for substance P and acid-sensing ion channel 1a in prolotherapy with dextrose-mediated analgesia in a mouse model of chronic muscle pain. Pain 163, DOI: 10.1097/j.pain.0000000000002440 (2022) [JCR] [WOS]
  4. Chu YC, Lim J, Chien A, (Chen CC), Wang JL Activation of Mechanosensitive Ion Channels by Ultrasound. Ultrasound in medicine & biology 48(10), 1981-1994 (2022) [JCR] [WOS]
  5. Lim J, Chu YC, Tai HH, Chien A, Huang SS, (Chen CC), Wang JL Auditory independent low-intensity ultrasound stimulation of mouse brain is associated with neuronal ERK phosphorylation and an increase of Tbr2 marked neuroprogenitors. Biochemical and biophysical research communications 613, 113-119 (2022) [JCR] [WOS]
  6. Chuang YC, Chen CC Force From Filaments: The Role of the Cytoskeleton and Extracellular Matrix in the Gating of Mechanosensitive Channels. Frontiers in cell and developmental biology 10, 886048 (2022) [JCR] [WOS]
  7. Hsu WH, Han DS, Ku WC, Chao YM, (Chen CC)*, Lin YL* Metabolomic and proteomic characterization of sng and pain phenotypes in fibromyalgia. European journal of pain (London, England) 26(2), 445-462 (2022) [JCR] [WOS]
  8. Lim J, Tai HH, Liao WH, Chu YC, Hao CM, Huang YC, Lee CH, Lin SS, Hsu S, Chien YC, Lai DM, Chen WS, (Chen CC)*, Wang JL* ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain. eLife 10, e61660 (2021) [JCR] [WOS]
  9. Lin JH, Yu YW, Chuang YC, Lee CH, (Chen CC)* ATF3-Expressing Large-Diameter Sensory Afferents at Acute Stage as Bio-Signatures of Persistent Pain Associated with Lumbar Radiculopathy. Cells 10(5), 992 (2021) [JCR] [WOS]
  10. Yeh HY, Lee JC, Chi HH, (Chen CC), Liu Q, Yen CT Longitudinal intravital imaging nerve degeneration and sprouting in the toes of spared nerve injured mice. The Journal of comparative neurology 529(12), 3247-3264 (2021) [JCR] [WOS]