Dr. Chen, Chih-Cheng 's publons link picture

Dr. Chen, Chih-Cheng

Deputy Director
Distinguished Research Fellow
  • 02-2652-3917
  • 02-2782-9224 (Fax)

  • Pain
  • Neurosensory Mechanotransduction

Education and Positions:
  • Ph.D. University College London, UK

Our research interest is molecular nociception, which is to understand the molecular mechanism and genetic control of pain sensation.

One of our major interests is in pain associated with tissue acidosis. Muscle pain is our current focus. The long-range goal is to understand and control the intractable chronic widespread pain, such as fibromyalgia, myofascial pain syndromes, etc.

The second major interest is related to the physiological and pathological roles of acid signaling. Due to the fact that tissue acidosis does not always cause pain, we notice that acid signaling may participate in neurotransmission and trigger biofeedback to modulate physiological homeostasis. Acid-sensing ion channels (ASICs)  are the major acid sensors in mammals. We are using genetic approaches to reveal the roles of ASICs in physiological homeostasis and neural modulation.

The third major interest is to probe the molecular identity and electrophysiological properties of stretch-activated ion channels that are responsible for neurosensory mechanotransduction. We aim to know the roles of the stretch-activated ion channels in chronic acid pain.

Our Team
Team photo

Journal 97 Book 3

  1. Hung CH, Chin Y, Fong YO, Lee CH, Han DS, Lin JH, Sun WH, (Chen CC)* Acidosis-related pain and its receptors as targets for chronic pain. Pharmacology & therapeutics 247, 108444 (2023) [JCR] [WOS]
  2. Wu CH, Chou WH, Long YH, Yang HH, Lin T, Yang CC, Sun WZ, (Chen CC), Lin CP Development of the Chronic Pain Cognition Scale: A Culture-Sensitive Pain Measurement in Chinese. Journal of pain research 16, 3075-3084 (2023) [JCR] [WOS]
  3. Lin YC, Lee CH, Sung JY, (Chen CC)* Genetic exploration of roles of acid-sensing ion channel subtypes in neurosensory mechanotransduction including proprioception. Experimental physiology doi: 10.1113/EP090762, doi: 10.1113/EP090762 (2023) [JCR] [WOS]
  4. Han DS, Lee CH, Shieh YD, Chang KV, Lin SH, Chu YC, Wang JL, (Chen CC)* Involvement of ASIC3 and Substance P in Therapeutic Ultrasound-Mediated Analgesia in Mouse Models of Fibromyalgia. The journal of pain 24(8), 1493-1505 (2023) [JCR] [WOS]
  5. Lee HH, (Chen CC)* Myalgia! Where does it come from? Acta neurologica Taiwanica 32(4), 230-239 (2023) [JCR] [WOS]
  6. Yang CT, Guan Y, (Chen CC), Lin WT, Lu KH, Lin CR, Shyu BC, Wen YR Novel Pulsed Ultrahigh-frequency Spinal Cord Stimulation Inhibits Mechanical Hypersensitivity and Brain Neuronal Activity in Rats after Nerve Injury. Anesthesiology 139(5), 646-663 (2023) [JCR] [WOS]
  7. Hung CH, Tsai MH, Wang PS, Liang FW, Hsu CY, Lee KW, Fong YO, Han DS, Lee CH, Lai CL, (Chen CC)* Oxidative stress involves phenotype modulation of morbid soreness symptoms in fibromyalgia. RMD open 9(1), e002741 (2023) [JCR] [WOS]
  8. Cheng YR, Chi CH, Lee CH, Lin SH, Min MY, (Chen CC)* Probing the Effect of Acidosis on Tether-Mode Mechanotransduction of Proprioceptors. International journal of molecular sciences 24(16), 12783 (2023) [JCR] [WOS]
  9. Lee CH, Chen CC Role of proprioceptors in chronic musculoskeletal pain. Experimental physiology doi: 10.1113/EP090989, doi: 10.1113/EP090989 (2023) [JCR] [WOS]
  10. Chiu HY, Su IW, Yu YW, Chen YC, (Chen CC), Lin JH Soreness or sng: a common symptom with differential clinical impact from pain in degenerative lumbar spine diseases. BMJ open quality 12(1), e001982 (2023) [JCR] [WOS]