林天南博士
兼任研究員
- 886-2-2789-9141 (Lab) (Room No: 404)
- 2652-3936 (Office)
- 2785-8847 (Fax)
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Specialty:
- Cerebral Ischemia
- Angiogenesis
- Neurochemistry
Education and Positions:
Ph.D. in Biochemistry, Univ. of Missouri-Columbia.
腦中風是造成死亡及成人殘疾的主因。但除了血栓溶解劑，並無其他方法可侷限腦的損傷。本實驗室的主要研究是要解開腦中風後神經傷害與功能復元的細胞與分子機制。我們的研究顯示，利用COX-1基因轉殖可增加血管新生因子(PGI2)進而刺激PPARγ而降低發炎反應和抑制Bad/ROS所造成的細胞凋亡，因此增強細胞的存活而有效的降低梗塞體積。所以，促進血管新生可作為是治療腦中風的方法之一。其他研究方向還包含: 血管新生的機制及中樞神經的基因與細胞治療。
我們最近也在研究中草藥對腦中風的影響. 我們發現忘憂草的萃取物藉由活化PPAR-r與抑制HDACs活性, 來降低神經細胞的死亡與腦梗塞的面積. 誠如 Louis Pasteur 所言: 預防勝於治療.
Our Team
期刊 70
專書 5
期刊 70 專書 5
- Farooqui AA, Farooqui T, Sun GY, (Lin TN), Teh DBL, Ong WY* COVID-19, Blood Lipid Changes, and Thrombosis. Biomedicines 11(4), 1181-1189 (2023-04) [JCR] [WOS]
- Kao MH, Huang CY, Cheung WM, Yan YT, Chen JJ, Ho YS, Hsu CY, (Lin TN)* Activating Transcription Factor 3 Diminishes Ischemic Cerebral Infarct and Behavioral Deficit by Downregulating Carboxyl-Terminal Modulator Protein. International journal of molecular sciences 24(3), 2306-2306 (2023-02) [JCR] [WOS]
- Ong WY, Kao MH, Cheung WM, Leow DM, Cheah IK, (Lin TN)* Protective Effect of Ergothioneine Against Stroke in Rodent Models. Neuromolecular medicine Online first, 1-11 (2022-10) [JCR] [WOS]
- Ong WY, Herr DR, Sun GY, (Lin TN) Anti-Inflammatory Effects of Phytochemical Components of Clinacanthus nutans. Molecules (Basel, Switzerland) 27(11), 3607 (2022-06) [JCR] [WOS]
- Kao MH, Wu JS, Cheung WM, Chen JJ, Sun GY, Ong WY, Herr DR, (Lin TN*) Clinacanthus nutans Mitigates Neuronal Death and Reduces Ischemic Brain Injury: Role of NF-kappaB-driven IL-1beta Transcription. Neuromolecular medicine 23(1), 199-210 (2021-01) [JCR] [WOS]
- Chen HL, Lo CH, Huang CC, Lu MP, Hu PY, Chen CS, Chueh DY, Chen P, (Lin TN), Lo YH, Hsiao YP, Hsu DK, Liu FT Galectin-7 downregulation in lesional keratinocytes contributes to enhanced IL-17A signaling and skin pathology in psoriasis. The Journal of clinical investigation 131(1), 1-10 (2021-01) [JCR] [WOS]
- Wu KH, Lee WJ, Cheng TC, Chang HW, Chen LC, Chen CC, Lien HM*, (Lin TN)*, Ho YS* Study of the antitumor mechanisms of apiole derivatives (AP-02) from Petroselinum crispum through induction of G0/G1 phase cell cycle arrest in human COLO 205 cancer cells. BMC complementary and alternative medicine 19(1), 188 (2019-07) [JCR] [WOS]
- Kao MH, (Lin TN)* Histone deacetylases in stroke. The Chinese journal of physiology 62(3), 95-107 (2019-05-06) [JCR] [WOS]
- Wu JS, Kao MH, Tsai HD, Cheung WM, Chen JJ, Ong WY, Sun GY, (Lin TN*) Clinacanthus nutans Mitigates Neuronal Apoptosis and Ischemic Brain Damage Through Augmenting the C/EBPbeta-Driven PPAR-gamma Transcription. Molecular neurobiology 55(7), 5425-5438 (2018) [JCR] [WOS]
- Ho CF, Bon CP, Ng YK, Herr DR, Wu JS, (Lin TN), Ong WY* Expression of DHA-Metabolizing Enzyme Alox15 is Regulated by Selective Histone Acetylation in Neuroblastoma Cells. Neurochemical research 43(3), 540-555 (2018) [JCR] [WOS]
