徐百川博士
兼任研究員
- 02-27899124 (Lab) (Room No: N327)
- 02-27829224 (Fax)
-
Specialty:
- Neurophysiology
- Electrophysiology
- Neuroimaging
- Pain
Education and Positions:
Ph.D. Goteborg Univ., Sweden
急性和慢性疼痛的情緒反應在腦中樞內側痛覺系統中大部分仍無法完全解釋清楚。對於內側痛覺系統來說，內側丘腦(medial thalamus)和前扣帶皮質(anterior cingulate cortex)間的神經元已經被證明能夠處理從細胞體傳入的高閾值疼痛訊息。我們的長期研究目標是研究急性和慢性疼痛在內側痛覺系統中所傳達的情感/情緒方面的痛覺機制。最近，我們把研究的重點放在探討中樞性中風後疼痛(Central post stroke pain)的神經機制。
在研究丘腦-扣帶皮質(thalamocingulate)間神經網路的活性過程中，我們開發了一種新的腦切片製備技術，這其中包含了完整的丘腦-扣帶皮質傳導途徑。這種腦切片的製備可以讓我們利用活體外的方法來研究丘腦-扣帶皮質迴路中細胞的基本訊息傳遞機制。我們還發現，我們可以在這種腦切片上誘發自發性的類癲癇活動，因此，它為我們提供了一個獨特的機會來研究扣帶皮質在類癲癇反應下的細胞活動機制。也正因為如此，我們發展了另一個研究的重點在癲癇研究上。在癲癇的研究中，我們研究的目的主要是為了解決以下問題：丘腦如何調控扣帶皮質所產生的癲癇，細胞間的間隙連(gap juctions)如何參與扣帶皮質所產生的癲癇的調控，以及直流電場刺激和丘腦網狀核光刺激對於大腦皮質癲癇的是如何調控。
Our Team
期刊 146
專書 14
期刊 146 專書 14
- Ou Chen Yin, Yu Ying Hao, Wu Chi-Wen, Kozłowska Anna, Shyu Bai-Chung, Huang Andrew Chih Wei Neuronal activity of the medial prefrontal cortex, nucleus accumbens, and basolateral amygdala in conditioned taste aversion and conditioned place preference induced by different doses of morphine administrations in rats Frontiers in Pharmacology 14, ePub (2023-01-24) [JCR] [WOS]
- Pei-Chun Chou, Chih-Min Liu, Ching-Hui Weng, Kai-Chien Yang, Mei-Ling Cheng, Yuh-Charn Lin, Ruey-Bing Yang, Bai-Chuang Shyu, Song-Kun Shyue, Jin-Dian Liu, Shih-Pin Chen, Michael Hsiao and Yu-Feng Hu Fibroblasts Drive Metabolic Reprogramming in Pacemaker Cardiomyocytes CIRCULATION RESEARCH 131(1), 6-20 (2022-05-25) [JCR] [WOS]
- Hsiang-Chin Lu, Wei-Jen Chang, Andrew Chih Wei Huang, Bai Chuang Shyu Detection of pentylenetetrazol-induced seizure activity in the 19-21 Hz beta range using a magnetic coil induction method. FRONTIERS IN BIOSCIENCE-LANDMARK 27(3), 81 (2022-05-05) [JCR] [WOS]
- Tavleen Kaur, Hsi-Chien Shih, Andrew Chih Wei Huang, Bai-Chuang Shyu Modulation of melatonin to the thalamic lesion-induced pain and comorbid sleep disturbance in the animal model of the central post-stroke hemorrhage. MOLECULAR PAIN 18, doi: 10.1177/17448069221127180 (2022-04-18) [JCR] [WOS]
- Wu CW, Ou CY, Yu YH, Yu YC, Shyu BC, Huang ACW. Involvement of the ventral tegmental area but not periaqueductal gray matter in the paradoxical rewarding and aversive effects of morphine. Behavioral Neuroscience 135(6), 762-770 (2021-12) [JCR] [WOS]
- Chin-Tsang Yang, Bai-Chuang Shyu, Yeong-Ray Wen. A brain recording system to study the effect of pulsed radiofrequency spinal cord stimulation on neuropathic pain. 2021 Taiwan Society for Neuroscience (TSfN) (2021-09) [JCR] [WOS]
- Hsi-Chien Shih, Tweety Kuan and Bai-Chung Shyu. Central Post-Stroke Pain was Suspended by Knockout of P2X7 Gene: A Mice Model Research. 2021 Taiwan Society for Neuroscience (TSfN) (2021-09) [JCR] [WOS]
- Tavleen Kaur, Bai-Chuang Shyu Neuromodulatory effect of exogenous melatonin on Central Post Stroke Pain in rodents. 2021 Taiwan Society for Neuroscience (TSfN) (2021-09) [JCR] [WOS]
- Chang SH, Shaw FZ, Shyu BC. The Temporal Profiling and Modulation of Traumatic Stress Related Fears in a Rat Model of Post-Traumatic Stress Disorder. ENCODS 2021 - European Neuroscience Conference by Doctoral Students (Virtual Forum) (2021-06) [JCR] [WOS]
- Shao-Han Chang, Ying Hao Yu, Alan He, Chen Yin Ou, Bai Chuang Shyu, Andrew Chih Wei Huang. BDNF Protein and BDNF mRNA Expression of the Medial Prefrontal Cortex, Amygdala, and Hippocampus during Situational Reminder in the PTSD Animal Model. Behavioral Neurology Volume 2021, 1-13 (2021-05-09) [JCR] [WOS]
