林文昌博士
研究員
- 02-27899148 (Lab) (Room No: N601)
- 02-26523967 (Office)
- 02-27827654 (Fax)
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Specialty:
- Bioinformatics and databases
- Tumor Biology and cancer biomarkers
- miRNA and protein-coding gene discovery
Education and Positions:
Ph.D. Case Western Reserve University
本研究室著重於開發生物資訊工具及資料庫，並將研究應用於改善癌症治療策略。對於蛋白質基因，我們建立數個人類同源基因研究之生物資訊資料庫應用於功能基因體，利用大規模基因表現資料庫，建立生物資訊工具來發現跨物種保留之同源蛋白質基因，並研究由單一核苷酸變異之功能性影響。此外，我們亦針對非編碼RNA基因進行生物資訊與分子生物學研究。其中，microRNA是極小片段的ncRNA，可以調控基因表現。 我們已建立數個microRNA發掘之生物資訊平台，並對於microRNA基因的轉錄調控進行深入研究。利用序列演化保留的特性，在五十餘個動物基因體中發現超過15000個以上高可信度的新microRNA基因。我們發現microRNA與人類癌症之關連性及血清與尿液中microRNA作為偵測癌症檢測(liquid biopsy)之應用。至今，一些已建立之線上生物資訊資料庫有：
Vir-Mir ; MetaMirClust ; Zoo-Mir ; CGI ; DODO ; GOOD ; dbDNV ; TREGT ; RTTPG ; miRTV ; TEx-MST
Our Team
期刊 121
專書 0
期刊 121 專書 0
- Kao Hsiao-Wei, Tsai Kuo-Wang, Lin Wen-chang Synergistic Effect of Metformin and Lansoprazole Against Gastric Cancer through Growth Inhibition International Journal of Medical Sciences 20(6), 717-724 (2023) [JCR] [WOS]
- Yarmishyn AA, Ishola AA, Chen CY, Verusingam ND, Rengganaten V, Mustapha HA, Chuang HK, Teng YC, Phung VL, Hsu PK, Lin WC, Ma HI, Chiou SH, Wang ML Circular RNAs Modulate Cancer Hallmark and Molecular Pathways to Support Cancer Progression and Metastasis. Cancers 14(4), 862 (2022) [JCR] [WOS]
- Tung KF, Pan CY, Lin WC Dominant transcript expression profiles of human protein-coding genes interrogated with GTEx dataset. Scientific reports 12(1), 6969 (2022) [JCR] [WOS]
- Su PY, Yen SB, Yang CC, Chang CH, Lin WC, Shih C Hepatitis B virus virion secretion is a CRM1-spike-mediated late event. Journal of biomedical science 29(1), 44 (2022) [JCR] [WOS]
- Yang YP, Lee AC, Lin LT, Chen YW, Huang PI, Ma HI, Chen YC, Lo WL, Lan YT, Fang WL, Wang CY, Liu YY, Hsu PK, Lin WC, Li CP, Chen MT, Chien CS, Wang ML Strategic Decoy Peptides Interfere with MSI1/AGO2 Interaction to Elicit Tumor Suppression Effects. Cancers 14(3), 505 (2022) [JCR] [WOS]
- Tung Kuo-Feng, Lin Wen-chang TEx-MST: tissue expression profiles of MANE select transcripts DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION 2022, baac089 (2022) [JCR] [WOS]
- Yang YP, Chien CS, Yarmishyn AA, Chan MS, Lee AC, Chen YW, Huang PI, Ma HI, Lo WL, Chien Y, Lin WC, Wang ML, Chen MT Musashi-1 Regulates MIF1-Mediated M2 Macrophage Polarization in Promoting Glioblastoma Progression. Cancers 13(8), 1799 (2021) [JCR] [WOS]
- Chen Chao-Hsin, Tung Kuo-Fong, Lin Wen-Chang Exploration of deep-learning based classification with human SNP image graphs bioRxiv (2021) [JCR] [WOS]
- Pan Chao-Yu, Lin Wen-Chang miR-TV: an interactive microRNA Target Viewer for microRNA and target gene expression interrogation for human cancer studies DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION 2020, baz148 (2020) [JCR] [WOS]
- Tung Kuo-Feng, Pan Chao-Yu, Chen Chao-Hsin, Lin Wen-chang Top-ranked expressed gene transcripts of human protein-coding genes investigated with GTEx dataset Scientific Reports 10(1), 16245 (2020) [JCR] [WOS]
