Dr. Jou, Yuh-Shan 's orcid link picture Dr. Jou, Yuh-Shan 's publons link picture

周玉山博士

特聘研究員
  • 27899062,26523525(Lab) (Lab) (Room No: N606)
  • 26523521(O)
  • 27827654 (Fax)

Specialty:
  • Cancer Genomics
  • Molecular Cancer Biology
  • Bioinformatics

Education and Positions:
  • Ph.D., Michigan State University


我們實驗室專注於研究台灣重要常見癌症的新穎預後驅動基因,也進一步揭示其病理及分子致癌機制和開發治療新穎策略。我們應用尖端的基因體學,生物資訊學和分子細胞生物學等方法來剖析致癌途徑,研究腫瘤進展的分子機制並製定治療策略。

 癌症驅動基因的相關研究方向:

(1)我們研究了異常PSPC1在促轉移性腫瘤重編程中的致瘤機制;
(2)我們採用整合的基因組學和生物信息學方法來確定用於人類肝細胞癌(HCC)和肺腺癌的診斷和治療的創新目標;
(3)我們研究了新的體細胞編碼和非編碼基因參與腫瘤發病機制的分子機制。

癌症基因體學及生物資訊學相關研究方向:
(1)OncoDB.glycogene:醣基化相關基因的綜合癌症基因體資料庫
(2)IGRhCellID:用於鑑定的人類細胞系的整合基因體資料庫
(3)IGDB.NSCLC:非小細胞肺癌的綜合基因體資料庫
(4)OncoDB.HCC:肝細胞癌的癌基因體資料庫
(5)TPMD:台灣多態性標桿數據資料庫

我們應用整合的基因體研究方法揭示了癌症基因體的全基因體變異,並建立了全面的癌症基因體資料庫,以促進發現新穎的癌症驅動基因,以進行病理及分子致癌機制研究,並研發新穎治療策略,以延長癌症患者的壽命為目標。

Our Team
Team photo

期刊 87 專書 0

  1. Chen KJ, Huang JH, Shih JH, Gu DL, Lee SS, Shen R, Hsu YH, Kung YC, Wu CY, Ho CM, Jen HW, Lee HY, Lang YD, Hsiao CH, Jou YS Somatic A-to-I RNA-edited RHOA isoform 2 specific-R176G mutation promotes tumor progression in lung adenocarcinoma.. Molecular carcinogenesis (2023) [JCR] [WOS]
  2. Wang YW, Chen SC, Gu DL, Yeh YC, Tsai JJ, Yang KT, Jou YS, Chou TY, Tang TK A novel HIF1alpha-STIL-FOXM1 axis regulates tumor metastasis.. Journal of biomedical science 29(1), 24 (2022) [JCR] [WOS]
  3. Chen HY, Chan SJ, Liu X, Wei AC, Jian RI, Huang KW, Lang YD, Shih JH, Liao CC, Luan CL, Kao YT, Chiang SY, Hsiao PW, Jou YS, Chen Y, Chen RH Long noncoding RNA Smyca coactivates TGF-beta/Smad and Myc pathways to drive tumor progression.. Journal of hematology & oncology 15(1), 85 (2022) [JCR] [WOS]
  4. Ho CM, Lin KT, Shen R, Gu DL, Lee SS, Su WH, Jou YS Prognostic comparative genes predict targets for sorafenib combination therapies in hepatocellular carcinoma.. Computational and structural biotechnology journal 20, 1752-1763 (2022) [JCR] [WOS]
  5. Lang YD, Jou YS PSPC1 is a new contextual determinant of aberrant subcellular translocation of oncogenes in tumor progression.. Journal of biomedical science 28(1), 57 (2021) [JCR] [WOS]
  6. Jen Hsin-Wei, Gu De-Leung, Lang Yaw-Dong, Jou Yuh-Shan PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility. Cells 9(6), 1490 (2020-06) [JCR] [WOS]
  7. Shih JH, Chen HY, Lin SC, Yeh YC, Shen R, Lang YD, Wu DC, Chen CY, Chen RH, Chou TY, Jou YS* Integrative analyses of noncoding RNAs reveal the potential mechanisms augmenting tumor malignancy in lung adenocarcinoma.. Nucleic acids research 48(3),1175-1191 (2020-02) [JCR] [WOS]
  8. Lang Yaw-Dong, Jou Yuh-Shan PSPC1: a contextual determinant of tumor progression. Molecular & Cellular Oncology 7(2), 1721253 (2020-02) [JCR] [WOS]
  9. Lang YD, Chen HY, Ho CM, Shih JH, Hsu EC, Shen R, Lee YC, Chen JW, Wu CY, Yeh HW, Chen RH, Jou YS* PSPC1-interchanged interactions with PTK6 and beta-catenin synergize oncogenic subcellular translocations and tumor progression.. Nature communications 10(1), 5716 (2019-12) [JCR] [WOS]
  10. Yeh HW, Lee SS, Chang CY, Lang YD, Jou YS* A New Switch for TGFbeta in Cancer.. Cancer research 79(15), 3797-3805 (2019-08) [JCR] [WOS]

- 研究助理 -
member
龔穎之