Dr. Jou, Yuh-Shan 's orcid link picture Dr. Jou, Yuh-Shan 's publons link picture

Dr. Jou, Yuh-Shan

Distinguished Research Fellow
  • 27899062,26523525(Lab) (Lab) (Room No: N606)
  • 26523521(O)
  • 27827654 (Fax)

  • Cancer Genomics
  • Molecular Cancer Biology
  • Bioinformatics

Education and Positions:
  • Ph.D., Michigan State University

We are interesting in finding the innovative and prognostic cancer driver genes of prevalent cancers in Taiwan for revealing the pathological mechanisms and developing therapeutic strategies. We apply cutting-edge approaches such as genomics, bioinformatics, and molecular cell biology to dissect tumorigenic pathways, to study molecular mechanisms of tumor progression and to develop therapeutic strategies.

 Projects in cancer driver genes:

  1. We investigate tumorigenic mechanisms of aberrant PSPC1 in pro-metastatic tumor reprogramming;
  2. We apply integrated genomics and bioinformatics approaches to identify innovative targets for diagnosis and therapy in human hepatocellular carcinoma (HCC) and lung adenocarcinoma;
  3. We study molecular mechanisms of novel somatic coding and non-coding genes involved in tumor pathogenesis.

 Projects in cancer genomics and bioinformatics:

  1. OncoDB.Glycogene: An integrated cancer genomic database for glycosylation-related genes
  2. IGRhCellID: integrated genomic resources of human cell lines for identification
  3. IGDB.NSCLC: integrated genomic database of non-small cell lung cancer
  4. OncoDB.HCC: oncogenomic database of hepatocellular carcinoma
  5. TPMD: Taiwan Polymorphic Markers Database

We applied integrated genomic approaches to reveal genome-wide alterations of cancer genomes and established comprehensive cancer databases to facilitate discovery of innovative cancer driver genes for pathological and mechanistic studies and for developing strategies in therapeutic interventions to prolong life of cancer patients.

Our Team
Team photo

Journal 86 Book 0

  1. Chen KJ, Huang JH, Shih JH, Gu DL, Lee SS, Shen R, Hsu YH, Kung YC, Wu CY, Ho CM, Jen HW, Lee HY, Lang YD, Hsiao CH, Jou YS Somatic A-to-I RNA-edited RHOA isoform 2 specific-R176G mutation promotes tumor progression in lung adenocarcinoma. Molecular carcinogenesis (2023) [JCR] [WOS]
  2. Wang YW, Chen SC, Gu DL, Yeh YC, Tsai JJ, Yang KT, Jou YS, Chou TY, Tang TK A novel HIF1alpha-STIL-FOXM1 axis regulates tumor metastasis. Journal of biomedical science 29(1), 24 (2022) [JCR] [WOS]
  3. Chen HY, Chan SJ, Liu X, Wei AC, Jian RI, Huang KW, Lang YD, Shih JH, Liao CC, Luan CL, Kao YT, Chiang SY, Hsiao PW, Jou YS, Chen Y, Chen RH Long noncoding RNA Smyca coactivates TGF-beta/Smad and Myc pathways to drive tumor progression. Journal of hematology & oncology 15(1), 85 (2022) [JCR] [WOS]
  4. Ho CM, Lin KT, Shen R, Gu DL, Lee SS, Su WH, Jou YS Prognostic comparative genes predict targets for sorafenib combination therapies in hepatocellular carcinoma. Computational and structural biotechnology journal 20, 1752-1763 (2022) [JCR] [WOS]
  5. Lang YD, Jou YS PSPC1 is a new contextual determinant of aberrant subcellular translocation of oncogenes in tumor progression. Journal of biomedical science 28(1), 57 (2021) [JCR] [WOS]
  6. Jen Hsin-Wei, Gu De-Leung, Lang Yaw-Dong, Jou Yuh-Shan PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility Cells 9(6), 1490 (2020-06) [JCR] [WOS]
  7. Shih JH, Chen HY, Lin SC, Yeh YC, Shen R, Lang YD, Wu DC, Chen CY, Chen RH, Chou TY, Jou YS* Integrative analyses of noncoding RNAs reveal the potential mechanisms augmenting tumor malignancy in lung adenocarcinoma. Nucleic acids research 48(3),1175-1191 (2020-02) [JCR] [WOS]
  8. Lang Yaw-Dong, Jou Yuh-Shan PSPC1: a contextual determinant of tumor progression Molecular & Cellular Oncology 7(2), 1721253 (2020-02) [JCR] [WOS]
  9. Lang YD, Chen HY, Ho CM, Shih JH, Hsu EC, Shen R, Lee YC, Chen JW, Wu CY, Yeh HW, Chen RH, Jou YS* PSPC1-interchanged interactions with PTK6 and beta-catenin synergize oncogenic subcellular translocations and tumor progression. Nature communications 10(1), 5716 (2019-12) [JCR] [WOS]
  10. Yeh HW, Lee SS, Chang CY, Lang YD, Jou YS* A New Switch for TGFbeta in Cancer. Cancer research 79(15), 3797-3805 (2019-08) [JCR] [WOS]

Kung, Ying-Chih