Ph.D., Michigan State University
We are interesting in finding the innovative and prognostic cancer driver genes of prevalent cancers in Taiwan for revealing the pathological mechanisms and developing therapeutic strategies. We apply cutting-edge approaches such as genomics, bioinformatics, and molecular cell biology to dissect tumorigenic pathways, to study molecular mechanisms of tumor progression and to develop therapeutic strategies.
Projects in cancer driver genes:
Projects in cancer genomics and bioinformatics:
We applied integrated genomic approaches to reveal genome-wide alterations of cancer genomes and established comprehensive cancer databases to facilitate discovery of innovative cancer driver genes for pathological and mechanistic studies and for developing strategies in therapeutic interventions to prolong life of cancer patients.
Somatic A-to-I RNA-edited RHOA isoform 2 specific-R176G mutation promotes tumor progression in lung adenocarcinomaMolecular Carcinogenesis, Dec 01, 2022
Prognostic comparative genes predict targets for sorafenib combination therapies in hepatocellular carcinomaComput Struct Biotechnol J, Apr 20, 2022