白果能博士

研究員
Specialty:
  • Cancer genomics
  • Molecular diagnostics
  • Nucleic acid therapeutics
Education and Positions:

  • Ph.D. University of Michigan-Ann Arbor

標靶療法為近年來癌症治療的一大突破。然而許多標靶基因不僅存在於癌細胞也存在於正常細胞，欲針對癌細胞來拮抗其含有的標靶基因而不影響正常細胞仍為醫療研究的一大挑戰。適體(aptamer)為核酸分子，可依序列不同而形成許多穩定的結構，如同抗體可專一地與特定標的分子結合。 本實驗室研究方向為研發新科技來搜尋癌細胞特定的表面蛋白質、受體、癌轉移及生長相關基因並驗證其功能，同時篩選可辨識癌細胞表面特定受體的適體來專一地辨識並活化癌細胞特有表面受體。辨識癌細胞表面受體的適體分子可用來傳輸siRNAs或DNAzymes，並利用受體的endocytosis作用將siRNA或DNAzyme分子送入細胞內來抑制癌細胞生長及轉移相關基因的表達。目前研究方向為利用多種不同適體來輸送前述核酸藥劑同時作用在癌細胞內多種標靶基因、對偶基因、轉錄異型等。本實驗室研究目標為開創一個全新的癌症治療方法，針對癌細胞獨有的轉移相關基因、對偶基因、偶合毀滅(synthetic lethality)對應基因來發展核酸藥劑，以期消滅癌細胞但避免對正常細胞產生副作用。

期刊 46 專書 5

  1. Tzu-Hung Hsiao, Chien-Hong Lin, Te-Tsui Lee, Ji-Yen Cheng, Pei-Kuen Wei, Eric Y. Chuang, Konan Peck Verifying expressed transcript variants by detecting and assembling stretches of consecutive exons NUCLEIC ACIDS RESEARCH 38, e187 (2010-08) [JCR] [WOS]
  2. Yeh-Hsing Lao, Lin-Chi Chen, Yi-Chung Chang, Chun-Wei Chi, Konan Peck Applications of Microarray in Aptamer Study Instruments Today 31(2), 95-102 (2009-10) [JCR] [WOS]
  3. Y. C. Chang, W. C. Kao, W. Y. Wang, W. Y. Wang, R. B. Yang, K. Peck Identification and characterization of oligonucleotides that inhibit Toll-like receptor 2-associated immune responses FASEB JOURNAL 23(9), 3078-3088 (2009-09) [JCR] [WOS]
  4. Lao YH, Peck K, Chen LC Enhancement of Aptamer Microarray Sensitivity through Spacer Optimization and Avidity Effect. ANALYTICAL CHEMISTRY 81,1747-1754 (2009-03) [JCR] [WOS]
  5. K. Peck, L. C. Chen, S. C. Tzeng, Y. S. Kao, W. C. Kao DNA aptamer for molecular recognition and protein expression profiling JOURNAL OF GENETICS AND MOLECULAR BIOLOGY 19, 263-269 (2008) [JCR] [WOS]
  6. K. Peck Kallikreins and Cancer Encyclopedia of Cancer; 2nd ed 1587-1590 (2008) [JCR] [WOS]
  7. Chou CC, Peck K Design and fabrication of spotted long oligonucleotide microarrays for gene expression analysis. Methods in molecular biology (Clifton, N.J.) 381, 213-225 (2007) [JCR] [WOS]
  8. M. J. Chen, P. P. Chiou, P. Lin, S. Siri, K. Peck and T. T. Chen Suppression of growth and cancer-induced angiogenesis of aggressive human breast cancer cells (MDA-MB-231) on the chorioallantoic membrane of developing chicken embryos by E-peptide of pro-IGF-I JOURNAL OF CELLULAR BIOCHEMISTRY 101, 1316-1327 (2007) [JCR] [WOS]
  9. Y. A. Chen, C. C. Chou, X. Lu, E. H. Slate, K. Peck, W. Xu, E. O. Voit and J. S. Almeida A multivariate prediction model for microarray cross-hybridization BMC BIOINFORMATICS 7, 101 (2006) [JCR] [WOS]
  10. A. Semenyuk, M. Ahnfelt, C. Estmer, Yong-Hao, A. Foldesi, Y. S. Kao, H. H. Chen, W. C. Kao, K. Peck and M. Kwiatkowski Cartridge-based high-throughput purification of oligonucleotides for reliable oligonucleotide arrays ANALYTICAL BIOCHEMISTRY 356(1), 132-141 (2006) [JCR] [WOS]
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