Dr. Peck, Konan

Research Fellow

  • Cancer genomics
  • Molecular diagnostics
  • Nucleic acid therapeutics

Education and Positions:
  • Ph.D. University of Michigan-Ann Arbor

This laboratory aims to develop technologies enabling cell-specific delivery of nucleic acid therapeutic agents for personalized cancer therapy. Oligonucleotides of different sequences can fold into different conformations to bind to their protein targets with high specificity and affinity. These structured oligonucleotides are known as aptamers. This laboratory has integrated bioinformatics, genomics, and proteomics technologies to identify several surface marker proteins on cancer cells. Functional aptamers specific to cancer cell surface marker proteins are employed to deliver siRNAs and/or DNAzymes into cancer cells by the receptor mediated endocytosis process to knock down the metastasis and cell proliferation associated signaling pathways. Cocktail therapy using cancer cell-specific aptamers conjugated with different allele-specific and/or transcript-specific nucleic acid therapeutic agents against various pivotal gene transcripts are being devised to knock down signaling pathways involved in the metastasis cascade and cell proliferation. The goal of these studies is to develop novel therapeutics to inhibit metastasis and to eradicate cancer cells with minimal side effects by synthetic lethal killing and allele-specific or transcript-specific therapeutic agents.

  1. Tzu-Hung Hsiao, Chien-Hong Lin, Te-Tsui Lee, Ji-Yen Cheng, Pei-Kuen Wei, Eric Y. Chuang, Konan Peck Verifying expressed transcript variants by detecting and assembling stretches of consecutive exons NUCLEIC ACIDS RESEARCH 38, e187 (2010-08) [JCR] [WOS]
  2. Yeh-Hsing Lao, Lin-Chi Chen, Yi-Chung Chang, Chun-Wei Chi, Konan Peck Applications of Microarray in Aptamer Study Instruments Today 31(2), 95-102 (2009-10) [JCR] [WOS]
  3. Y. C. Chang, W. C. Kao, W. Y. Wang, W. Y. Wang, R. B. Yang, K. Peck Identification and characterization of oligonucleotides that inhibit Toll-like receptor 2-associated immune responses FASEB JOURNAL 23(9), 3078-3088 (2009-09) [JCR] [WOS]
  4. Lao YH, Peck K, Chen LC Enhancement of Aptamer Microarray Sensitivity through Spacer Optimization and Avidity Effect. ANALYTICAL CHEMISTRY 81,1747-1754 (2009-03) [JCR] [WOS]
  5. K. Peck, L. C. Chen, S. C. Tzeng, Y. S. Kao, W. C. Kao DNA aptamer for molecular recognition and protein expression profiling JOURNAL OF GENETICS AND MOLECULAR BIOLOGY 19, 263-269 (2008) [JCR] [WOS]
  6. K. Peck Kallikreins and Cancer Encyclopedia of Cancer; 2nd ed 1587-1590 (2008) [JCR] [WOS]
  7. Chou CC, Peck K Design and fabrication of spotted long oligonucleotide microarrays for gene expression analysis. Methods in molecular biology (Clifton, N.J.) 381, 213-225 (2007) [JCR] [WOS]
  8. M. J. Chen, P. P. Chiou, P. Lin, S. Siri, K. Peck and T. T. Chen Suppression of growth and cancer-induced angiogenesis of aggressive human breast cancer cells (MDA-MB-231) on the chorioallantoic membrane of developing chicken embryos by E-peptide of pro-IGF-I JOURNAL OF CELLULAR BIOCHEMISTRY 101, 1316-1327 (2007) [JCR] [WOS]
  9. Y. A. Chen, C. C. Chou, X. Lu, E. H. Slate, K. Peck, W. Xu, E. O. Voit and J. S. Almeida A multivariate prediction model for microarray cross-hybridization BMC BIOINFORMATICS 7, 101 (2006) [JCR] [WOS]
  10. A. Semenyuk, M. Ahnfelt, C. Estmer, Yong-Hao, A. Foldesi, Y. S. Kao, H. H. Chen, W. C. Kao, K. Peck and M. Kwiatkowski Cartridge-based high-throughput purification of oligonucleotides for reliable oligonucleotide arrays ANALYTICAL BIOCHEMISTRY 356(1), 132-141 (2006) [JCR] [WOS]