Dr. Roffler, Steve R. 's orcid link picture Dr. Roffler, Steve R. 's publons link picture

羅傅倫博士

特聘研究員
Division Chief
  • 02-2789-9152 (Lab) (Room No: N233)
  • 02-2652-3079 (Office)
  • 02-2782-9142 (Fax)

Specialty:
  1. Antibody Engineering
  2. Directed Molecular Evolution
  3. Prodrugs
  4. Anti-PEG antibodies
  5. Nanomedicines

Education and Positions:

Ph.D. University of California, Berkeley


1. 抗體工程:建構雙特異性抗體抗體,用以遞送奈米藥物至腫瘤,改善癌症治療的選擇性與療效。

2. 奈米醫藥:正在研發新穎的技術,將疏水性藥物穩定包覆於奈米微脂體。

3. 定向分子演化:本實驗室已研發出有力的篩選方法,分選出定向演化後的優化人類酵素。我們以此技術提高蛋白質的性能,應用於治療遺傳疾病,與抗體-酵素前驅藥物療法。此外,本實驗室亦發展於抗體融合瘤細胞中,快速演化高親和力抗體的技術。

4. 前驅藥物療法:發展在腫瘤微環境內能夠優先被活化的前驅藥物,瞭解其機制以及改善活化的條件。

5. 聚乙二醇抗體:本實驗室研發聚乙二醇抗體,用以檢測人類血液檢體中聚乙二醇修飾藥物含量。我們亦延伸相關研究,探討人體中已存在,或被誘發產生的聚乙二醇抗體,是否會影響聚乙二醇修飾醫藥的療效。

Our Team
Team photo

期刊 180 專書 2

  1. Liu Y, Mori T, Ito Y, Kuroki K, Hayashi S, Kohda D, Shimizu T, Ishida T, Roffler SR, Kaneko MK, Kato Y, Arimori T, Teramoto T, Takemura K, Ishibashi K, Katayama Y, Maenaka K, Kakuta Y, Kitao A, Mori T The strategy used by naive anti-PEG antibodies to capture flexible and featureless PEG chains.. JOURNAL OF CONTROLLED RELEASE 380, 396-403 (2025-02) [JCR] [WOS]
  2. Meng JL, Dong ZX, Chen YR, Lin MH, Liu YC, Roffler SR, Lin WW, Chang CY, Tzou SC, Cheng TL, Huang HC, Li ZQ, Lin YC, Su YC pH-Responsive polyethylene glycol engagers for enhanced brain delivery of PEGylated nanomedicine to Treat Glioblastoma.. ACS NANO 19(1), 307-321 (2025-01) [JCR] [WOS]
  3. Ho KW, Liu YL, Huang BC, Hong ST, Yang SH, Liao TY, Liu ES, Chen YT, Huang YZ, Leu YL, Chen CY, Chen BM, Roffler SR, Cheng TL Targeted internalization and activation of glycosidic switch liposomes by a biological macromolecule mPEGxEphA2 increases therapeutic efficacy against lung cancer.. International journal of biological macromolecules 300, 140138 (2025-01) [JCR] [WOS]
  4. Chen Bing-Mae, Chen Even, Lin Yi-Chen, Tran Trieu Thi My, Turjeman Keren, Yang Shih-Hung, Cheng Tian-Lu, Barenholz Yechezkel, Roffler Steve R. Liposomes with Low Levels of Grafted Poly(ethylene glycol) Remain Susceptible to Destabilization by Anti-Poly(ethylene glycol) Antibodies. ACS Nano epub ahead of print, NA-NA (2024-08) [JCR] [WOS]
  5. Tseng Yi-Han, Lin Hsuan-Pei, Lin Sung-Yao, Chen Bing-Mae, Vo Thanh Nguyet Nguyen, Yang Shih-Hung, Lin Yi-Chen, Prijovic Zeljko, Czosseck Andreas, Leu Yu-Lin, Roffler Steve R Engineering stable and non-immunogenic immunoenzymes for cancer therapy via in situ generated prodrugs. Journal of Controlled Release 369, 179-198 (2024-05) [JCR] [WOS]
  6. Liu YL, Liao TY, Ho KW, Liu ES, Huang BC, Hong ST, Hsieh YC, Chang MS, Wu BT, Chen FM, Roffler SR, Chen CY, Yang YC, Cheng TL Impact of Pre-existing Anti-polyethylene Glycol Antibodies on the Pharmacokinetics and Efficacy of a COVID-19 mRNA Vaccine (Comirnaty) In Vivo.. Biomaterials research 28, 0112 (2024) [JCR] [WOS]
  7. Tran Trieu TM, Roffler Steve R Interactions between nanoparticle corona proteins and the immune system. Current Opinion in Biotechnology 84, 103010 (2023-12) [JCR] [WOS]
  8. Chen Huei-Jen, Cheng Yi-An, Chen Yu-Tung, Li Chia-Ching, Huang Bo-Cheng, Hong Shih-Ting, Chen I.-Ju, Ho Kai-Wen, Chen Chiao-Yun, Chen Fang-Ming, Wang Jaw-Yuan, Roffler Steve R., Cheng Tian-Lu, Wu Dung-Ho Targeting and internalizing PEGylated nanodrugs to enhance the therapeutic efficacy of hematologic malignancies by anti-PEG bispecific antibody (mPEG × CD20). Cancer Nanotechnology 14(1), 78 (2023-10) [JCR] [WOS]
  9. Beishenaliev Adilet, Loke Yean Leng, Goh Sook Jing, Geo Hui Nee, Mugila Malar, Misran Misni, Chung Lip Yong, Kiew Lik Voon, Roffler Steve, Teo Yin Yin Bispecific antibodies for targeted delivery of anti-cancer therapeutic agents: A review. Journal of Controlled Release 359, 268-286 (2023-07) [JCR] [WOS]
  10. Chen Wei-An, Chang Deng-Yuan, Chen Bing-Mae, Lin Yi-Chen, Barenholz Yechezekel, Roffler Steve R. Antibodies against Poly(ethylene glycol) Activate Innate Immune Cells and Induce Hypersensitivity Reactions to PEGylated Nanomedicines. ACS Nano 17(6), 5757-5772 (2023-03) [JCR] [WOS]

- 博士後研究 -
member
曾羿涵
- 研究助理 -
member
吳品逸
Yang, Seymour
楊世弘
- 昔日夥伴 -
member
唐璽楊
member
張鐙元
Lin, Ronald
林奕辰

2017    MOST Outstanding Research Award

2018    14th Tien Te Lee Outstanding Award (14th永信李天德醫藥科技)

2018    25th TECO Technology Foundation’s Outstanding Achievement Award in Biomedical Technology (第二十五屆東元獎)

2019    Ministry of Economic Affairs 6th National Industrial Innovation Award (第6屆經濟部國家產業創新獎個人類獎項)

2020    MOST Outstanding Research Award

2022    Outstanding Research Award of the Taiwan Nanomedicine Society

2022    Ministry of Education’s 63rd Annual Academic Award (63屆教育部學術獎)