Shieh, Sheau-Yann - IBMS, Sinica

癌症的發生與基因體的變異、不穩定性息息相關，而細胞週期(Cell cycle)的調控是維持基因體穩定性的一個必要工具。在DNA斷裂、或受到氧化或其他不當修飾而改變時，細胞週期的管控機制(Checkpoint)會啟動進而促使細胞休止、凋亡、或進行修復。這些管控蛋白參與訊息傳遞、細胞反應、甚或DNA修復，在維持基因體穩定性上以及抑制癌症的產生扮演了不可或缺的角色。我們的主要研究目標在於瞭解其中三個相關的訊息傳遞途徑：(一) 與抑癌蛋白相關的調控路徑包括其下游所管控的標的以及它們在維持基因體穩定性上的功能；(二)管控點激酶(Checkpoint kinase) CHK1、CHK2的調控標的及作用機制；(三)這些管控機制與DNA修補機制的相互關係以及對腫瘤形成的影響。

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期刊 36 專書 2

Chowdhury MAN, Wang SW, Suen CS, Hwang MJ, Hsueh YA, Shieh SY JAK2-CHK2 signaling safeguards the integrity of the mitotic spindle assembly checkpoint and genome stability. Cell death & disease 13(7), 619 (2022) [JCR] [WOS]

Yu-Che Cheng, Sheau-Yann Shieh* Determination of CHK1 Cellular Localization by Immunofluorescence Microscopy Cell Cycle Checkpoints. Methods in Molecular Biology Vol. 2267 1-6 (2021-01) [JCR] [WOS]

Cheng YC, Chiang HY, Cheng SJ, Chang HW, Li YJ, (Shieh SY)* Loss of the tumor suppressor BTG3 drives a pro-angiogenic tumor microenvironment through HIF-1 activation CELL DEATH & DISEASE 11(12), 1046 (2020-12) [JCR] [WOS]

Hsu PC, Gopinath RK, Hsueh YA, Shieh SY CHK2-mediated regulation of PARP1 in oxidative DNA damage response. Oncogene 38(8), 1166–1182 (2019-02) [JCR] [WOS]

Cheng YC, Shieh SY Deubiquitinating enzyme USP3 controls CHK1 chromatin association and activation. Proceedings of the National Academy of Sciences of the United States of America 115(21), 5546-5551 (2018) [JCR] [WOS]

Chang CH, Kuo CJ, Ito T, Su YY, Jiang ST, Chiu MH, Lin YH, Nist A, Mernberger M, Stiewe T, Ito S, Wakamatsu K, Hsueh YA, Shieh SY, Snir-Alkalay I, Ben-Neriah Y CK1alpha ablation in keratinocytes induces p53-dependent, sunburn-protective skin hyperpigmentation. Proceedings of the National Academy of Sciences of the United States of America 114(38), E8035-E8044 (2017) [JCR] [WOS]

Yu ZC, Huang YF, Shieh SY Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylation. Nucleic acids research 44(3), 1133-1150 (2016) [JCR] [WOS]

Cheng YC, Chen PH, Chiang HY, Suen CS, Hwang MJ, Lin TY, Yang HC, Lin WC, Lai PL, Shieh SY Candidate tumor suppressor B-cell translocation gene 3 impedes neoplastic progression by suppression of AKT. Cell Death & Disease 6, e1584 (2015) [JCR] [WOS]

Yeh CW, Yu ZC, Chen PH, Cheng YC, Shieh SY Phosphorylation at Threonine 288 by Cell Cycle Checkpoint Kinase 2 (CHK2) Controls Human Monopolar Spindle 1 (Mps1) Kinetochore Localization. The Journal of biological chemistry 289(22), 15319-15327 (2014) [JCR] [WOS]

Cheng YC, Lin TY, Shieh SY Candidate tumor suppressor BTG3 maintains genomic stability by promoting Lys63-linked ubiquitination and activation of the checkpoint kinase CHK1. Proceedings of the National Academy of Sciences of the United States of America 110(15), 5993-5998 (2013) [JCR] [WOS]

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鄭宇哲

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學經歷

B.S. - 1999, Department of Biomedical Sciences, Chung Shan Medical University, Taichung, Taiwan
M.S. - 2004, College of Oral Medicine, Chung Shan Medical University, Taichung, Taiwan
Ph.D. - 2006, Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan

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李依儒

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學經歷

M.S. of Institute of Molecular Biology, National Chung Hsing University, Taiwan

王士瑋

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學經歷

M.S. of Department of Biological Sciences, National Sun Yat-sen University

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周納言

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學經歷

Graduate Student, Molecular Medicine, PhD Fellowships at the Taiwan International Graduate Program
Masters of Science in Genetic Engineering and Biotechnology, SUST, Bangladesh.
Bachelor of Science in Genetic Engineering and Biotechnology, SUST, Bangladesh.