Dr. Yang, Pan-Chyr 's publons link picture

楊泮池博士

合聘研究員
中央研究院院士
  • 02-27899149 (Lab) (Room No: 511)
  • 02-27858594 (Fax)

Specialty:
  • Cell and Molecular Biology
  • Cancer genomics

Education and Positions:
  • M.D., Ph.D. National Taiwan University


本實驗室的研究重點主要有下列三個方向

(1)國人肺癌的基因體及轉譯醫學研究。
(2)癌轉移之分子調控機制。
(3)肺癌之生物標誌及個人化醫療。

我們以國人不抽菸肺腺癌為主要研究重點,並以全基因體相關性研究,基因微陣列、蛋白體及代謝體等技術,利用肺癌病人之組織及血液檢體及所建立之國人肺癌之細胞株,找出國人肺腺癌之相關危險基因,可能的致癌基因及相關訊息傳遞途徑,特別針對EGFR訊息傳遞途徑在國人肺腺癌發生之角色。

本實驗室也參與發展新的標靶治療及研發解決肺癌藥物治療抗藥性之問題等,進一步了解國人肺腺癌之發病機制及並期能發展創新治療方式及防治策略,以協助解決國人肺腺癌之重要健康問題。

Our Team
Team photo

  1. Hung PF, Hong TM, Chang CC, Hung CL, Hsu YL, Chang YL, Wu CT, Chang GC, Chan NL, Yu SL, Yang PC, Pan SH Hypoxia-induced Slug SUMOylation enhances lung cancer metastasis. Journal of experimental & clinical cancer research : CR 38(1), 5 (2019) [JCR] [WOS]
  2. Tseng SJ, Kempson IM, Huang KY, Li HJ, Fa YC, Ho YC, Liao ZX, Yang PC Targeting Tumor Microenvironment by Bioreduction-Activated Nanoparticles for Light-Triggered Virotherapy. ACS nano 12(10), 9894-9902 (2018) [JCR] [WOS]
  3. Huang BT, Lai WY, Chang YC, Wang JW, Yeh SD, Lin EP, Yang PC A CTLA-4 Antagonizing DNA Aptamer with Antitumor Effect. Molecular Therapy-Nucleic Acids 8, 520-528 (2017) [JCR] [WOS]
  4. Lin CW, Wang LK, Wang SP, Chang YL, Wu YY, Chen HY, Hsiao TH, Lai WY, Lu HH, Chang YH, Yang SC, Lin MW, Chen CY, Hong TM, Yang PC Corrigendum: Daxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1alpha/HDAC1/Slug axis. Nature communications 8, 14502 (2017) [JCR] [WOS]
  5. Kao SH, Wang WL, Chen CY, Chang YL, Wu YY, Wang YT, Wang SP, Nesvizhskii AI, Chen YJ, Hong TM, Yang PC GSK3beta controls epithelial-mesenchymal transition and tumor metastasis by CHIP-mediated degradation of Slug. Oncogene 36(42), 5916 (2017) [JCR] [WOS]
  6. Wang YT, Pan SH, Tsai CF, Kuo TC, Hsu YL, Yen HY, Choong WK, Wu HY, Liao YC, Hong TM, Sung TY, Yang PC, Chen YJ Phosphoproteomics Reveals HMGA1, a CK2 Substrate, as a Drug-Resistant Target in Non-Small Cell Lung Cancer. Scientific reports 7, 44021 (2017) [JCR] [WOS]
  7. Lai WY, Huang BT, Wang JW, Lin PY, Yang PC A Novel PD-L1-targeting Antagonistic DNA Aptamer With Antitumor Effects. Molecular Therapy-Nucleic Acids 5(12), e397 (2016) [JCR] [WOS]
  8. Wang LK, Pan SH, Chang YL, Hung PF, Kao SH, Wang WL, Lin CW, Yang SC, Liang CH, Wu CT, Hsiao TH, Hong TM, Yang PC MDA-9/Syntenin-Slug transcriptional complex promote epithelial-mesenchymal transition and invasion/metastasis in lung adenocarcinoma. Oncotarget 7(1), 386-401 (2016) [JCR] [WOS]
  9. Kuo TC, Li LW, Pan SH, Fang JM, Liu JH, Cheng TJ, Wang CJ, Hung PF, Chen HY, Hong TM, Hsu YL, Wong CH, Yang PC Purine-Type Compounds Induce Microtubule Fragmentation and Lung Cancer Cell Death through Interaction with Katanin. Journal of medicinal chemistry 59(18), 8521-34 (2016) [JCR] [WOS]
  10. Tseng SJ, Huang KY, Kempson IM, Kao SH, Liu MC, Yang SC, Liao ZX, Yang PC Remote Control of Light-Triggered Virotherapy. ACS nano 10(11), 10339-10346 (2016) [JCR] [WOS]