Dr. Yang, Pan-Chyr 's publons link picture

Dr. Yang, Pan-Chyr

Joint Appointment Research Fellow
Academician, Academia Sinica
  • 02-27899149 (Lab) (Room No: 511)
  • 02-27858594 (Fax)

  • Cell and Molecular Biology
  • Cancer genomics

Education and Positions:
  • M.D., Ph.D. National Taiwan University

Our laboratory is aimed to explore the molecular mechanism of lung carcinogenesis and personalized therapy of lung cancer, which is the most important and endemic cancer in Taiwan. We focus on the following areas:

1. Functional genomics and translational research of lung cancer.
2. Molecular mechanism of EMT and cancer  metastasis.
3. Biomarker and personalized therapy of lung  cancer.

We have established lung cancer cell lines with different driver mutations and invasion/metastasis lung cancer cell line model. To reduce lung cancer mortality and improve treatment outcome, We establish national reference laboratory, provide standardized and high quality gene testing for all lung cancer patients. With the implementation of nation-wide gene testing and personalized therapy, the overall 5-year survival for NSCLC has been improved from 15.8% to 31.6% from 2009 to 2013. We also identified the susceptible gene loci for non-smoker lung adenocarcinoma in East Asia. Currently we are working on oncogenic mechanism and regulatory pathways involved in tumor progression and metastasis. We specifically focus on the EGFR signaling pathway. We are also developing new targeted therapy and decipher the mechanisms of drug resistance. We hope our discovery can provide further understanding of lung carcinogenesis and help to develop new therapeutics for lung cancer patients. 

Our Team
Team photo

Journal 40 Book 0

  1. Hung PF, Hong TM, Chang CC, Hung CL, Hsu YL, Chang YL, Wu CT, Chang GC, Chan NL, Yu SL, Yang PC, Pan SH Hypoxia-induced Slug SUMOylation enhances lung cancer metastasis. Journal of experimental & clinical cancer research : CR 38(1), 5 (2019) [JCR] [WOS]
  2. Tseng SJ, Kempson IM, Huang KY, Li HJ, Fa YC, Ho YC, Liao ZX, Yang PC Targeting Tumor Microenvironment by Bioreduction-Activated Nanoparticles for Light-Triggered Virotherapy. ACS nano 12(10), 9894-9902 (2018) [JCR] [WOS]
  3. Huang BT, Lai WY, Chang YC, Wang JW, Yeh SD, Lin EP, Yang PC A CTLA-4 Antagonizing DNA Aptamer with Antitumor Effect. Molecular Therapy-Nucleic Acids 8, 520-528 (2017) [JCR] [WOS]
  4. Lin CW, Wang LK, Wang SP, Chang YL, Wu YY, Chen HY, Hsiao TH, Lai WY, Lu HH, Chang YH, Yang SC, Lin MW, Chen CY, Hong TM, Yang PC Corrigendum: Daxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1alpha/HDAC1/Slug axis. Nature communications 8, 14502 (2017) [JCR] [WOS]
  5. Kao SH, Wang WL, Chen CY, Chang YL, Wu YY, Wang YT, Wang SP, Nesvizhskii AI, Chen YJ, Hong TM, Yang PC GSK3beta controls epithelial-mesenchymal transition and tumor metastasis by CHIP-mediated degradation of Slug. Oncogene 36(42), 5916 (2017) [JCR] [WOS]
  6. Wang YT, Pan SH, Tsai CF, Kuo TC, Hsu YL, Yen HY, Choong WK, Wu HY, Liao YC, Hong TM, Sung TY, Yang PC, Chen YJ Phosphoproteomics Reveals HMGA1, a CK2 Substrate, as a Drug-Resistant Target in Non-Small Cell Lung Cancer. Scientific reports 7, 44021 (2017) [JCR] [WOS]
  7. Lai WY, Huang BT, Wang JW, Lin PY, Yang PC A Novel PD-L1-targeting Antagonistic DNA Aptamer With Antitumor Effects. Molecular Therapy-Nucleic Acids 5(12), e397 (2016) [JCR] [WOS]
  8. Wang LK, Pan SH, Chang YL, Hung PF, Kao SH, Wang WL, Lin CW, Yang SC, Liang CH, Wu CT, Hsiao TH, Hong TM, Yang PC MDA-9/Syntenin-Slug transcriptional complex promote epithelial-mesenchymal transition and invasion/metastasis in lung adenocarcinoma. Oncotarget 7(1), 386-401 (2016) [JCR] [WOS]
  9. Kuo TC, Li LW, Pan SH, Fang JM, Liu JH, Cheng TJ, Wang CJ, Hung PF, Chen HY, Hong TM, Hsu YL, Wong CH, Yang PC Purine-Type Compounds Induce Microtubule Fragmentation and Lung Cancer Cell Death through Interaction with Katanin. Journal of medicinal chemistry 59(18), 8521-34 (2016) [JCR] [WOS]
  10. Tseng SJ, Huang KY, Kempson IM, Kao SH, Liu MC, Yang SC, Liao ZX, Yang PC Remote Control of Light-Triggered Virotherapy. ACS nano 10(11), 10339-10346 (2016) [JCR] [WOS]