Dr. Wang, I-Hsuan (Jessica)'s publons link picture Dr. Wang, I-Hsuan (Jessica)'s Personal Homepage

王宜萱博士

助研究員
  • 02-2652-3969 (Lab) (Room No: 507)
  • 02-2789-9123 (Office)
  • 02-2651-0774 (Fax)

Specialty:

Cell biology of viral infections

Virus entry and egress


Education and Positions:
  • Ph.D., University of Zurich

    Postdoc., The University of Tokyo


病毒感染是一個高度依賴宿主的動態過程。本實驗室致力於了解病毒是如何運用細胞的機構來達成感染及其本身的複製。

 

我們的研究工作目前著眼於流感病毒及新型冠狀病毒生活史晚期中病毒粒子組成、釋放及細胞間傳播的機制,這些步驟保證了具有感染性的子代病毒能被組裝及釋出,最終促成新一輪感染的進行。本實驗室整合了分子病毒學、細胞學、光學/電子顯微鏡以及電腦分析等不同領域的研究方法,來探究這些感染過程如何發生、以及期間病毒與宿主的相互關係,特別是細胞囊泡和細胞骨架所扮演的腳色。我們希望能夠更加了解這些互動在時間及空間上如何被調控,並期待能從中發現新的治療標的。

  1. Sun CP, Chiu CW, Wu PY, Tsung SI, Lee IJ, Hu CW, Hsu MF, Kuo TJ, Lan YH, Chen LY, Ng HY, Chung MJ, Liao HN, Tseng SC, Lo CH, Chen YJ, Liao CC, Chang CS, Liang JJ, Draczkowski P, Puri S, Chang YC, Huang JS, Chen CC, Kau JH, Chen YH, Liu WC, Wu HC, Hsu STD, (Wang IH*), Tao MH* Development of AAV-delivered broadly neutralizing anti-human ACE2 antibodies against SARS-CoV-2 variants Molecular Therapy 31(11), 3322-3336 (2023-11) [JCR] [WOS]
  2. Yang CF*, Liao CC, Hsu HW, Liang JJ, Chang CS, Ko HY, Chang RH, Tang WC, Chang MH, (Wang IH*), Lin YL* Human ACE2 protein is a molecular switch controlling the mode of SARS-CoV-2 transmission Journal of Biomedical Science 30(1), 87 (2023-10-12) [JCR] [WOS]
  3. Lee IJ, Lan YH, Wu PY, Wu YW, Chen YH, Tseng SC, Kuo TJ, Sun CP, Jan JT, Ma HH, Liao CC, Liang JJ, Ko HY, Chang CS, Liu WC, Ko YA, Chen YH, Sie ZL, Tsung SI, Lin YL, (Wang IH), Tao MH A receptor-binding domain-based nanoparticle vaccine elicits durable neutralizing antibody responses against SARS-CoV-2 and variants of concern. Emerging microbes & infections 12(1), 2149353 (2023) [JCR] [WOS]
  4. Lee IJ, Sun CP, Wu PY, Lan YH, (Wang IH), Liu WC, Yuan JPY, Chang YW, Tseng SC, Tsung SI, Chou YC, Kumari M, Lin YS, Chen HF, Chen TY, Lin CC, Chiu CW, Hsieh CH, Chuang CY, Cheng CM, Lin HT, Chen WY, Hsu FF, Hong MH, Liao CC, Chang CS, Liang JJ, Ma HH, Chiang MT, Liao HN, Ko HY, Chen LY, Ko YA, Yu PY, Yang TJ, Chiang PC, Hsu ST, Lin YL, Lee CC, Wu HC, Tao MH* A booster dose of Delta × Omicron hybrid mRNA vaccine produced broadly neutralizing antibody against Omicron and other SARS-CoV-2 variants JOURNAL OF BIOMEDICAL SCIENCE 29, 49 (2022-07-07) [JCR] [WOS]
  5. Sun CP#, Jan JT#, (Wang IH#), Ma HH, Ko HY, Wu PY, Kuo TJ, Liao HN, Lan YH, Sie ZL, Chen YH, Ko YA, Liao CC, Chen LY, Lee IJ, Tsung SI, Lai YJ, Chiang MT, Liang JJ, Liu WC, Wang JR, Yuan JPY, Lin YS, Tsai YC, Hsieh SL, Li CW, Wu HC, Ko TM, Lin YL*, Tao MH* (#Equal Contribution) Rapid generation of mouse model for emerging infectious disease with the case of severe COVID-19 PLOS Pathogens 17(8), e1009758 (2021) [JCR] [WOS]
  6. Zhong G, Fan S, Hatta M, Nakatsu S, Walters KB, Lopes TJS, (Wang J IH), Ozawa M, Karasin A, Li Y, Tong S, Donis RO, Neumann G, Kawaoka Y* Mutations in the Neuraminidase-Like Protein of Bat Influenza H18N11 Virus Enhance Virus Replication in Mammalian Cells, Mice, and Ferrets Journal of Virology 94(5), e01416-19 (2020-03) [JCR] [WOS]
  7. Ueki H, (Wang IH), Zhao D, Gunzer M, Kawaoka Y* Multicolor two-photon imaging of in vivo cellular pathophysiology upon influenza virus infection using the two-photon IMPRESS Nature Protocols 15, 1041–1065 (2020) [JCR] [WOS]
  8. Yasuhara A, Yamayoshi S, Kiso M, Sakai-Tagawa Y, Koga M, Adachi E, Kikuchi T, (Wang IH), Yamada S, Kawaoka Y* Antigenic drift originating from changes to the lateral surface of the neuraminidase head of influenza A virus. Nature microbiology 4(6), 1024-1034 (2019-06) [JCR] [WOS]
  9. (Wang IH), Burckhardt CJ, Yakimovich A, Greber UF* Imaging, Tracking and Computational Analyses of Virus Entry and Egress with the Cytoskeleton. VIRUSES-BASEL 10(4), pii: E166 (2018) [JCR] [WOS]
  10. Ueki H#, (Wang IH#), Fukuyama S, Katsura H, da Silva Lopes TJ, Neumann G, Kawaoka Y* (# Equal contribution) In vivo imaging of the pathophysiological changes and neutrophil dynamics in influenza virus-infected mouse lungs. Proceedings of the National Academy of Sciences of the United States of America 115(28), E6622-E6629 (2018) [JCR] [WOS]

- 博士後研究 -
Ju, Tsai-Kai
朱蔡豈
Hsu, Hung-Wei Max
許弘瑋
- 研究助理 -
member
陳昱銓
- 學生 -
Wu, Chen-Hui Henry
吳振輝
member
郭昕
- 昔日夥伴 -
Lin, Yan-Chia
林揚家
Chang, Ming-Hao
張明皓
Wu, Abe
吳遠哲
Lin, Pin-Ru
林品汝
Tsai, Wan-Ju
蔡宛儒