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Dr. Wang, I-Hsuan (Jessica)

Assistant Research Fellow
  • 02-2652-3969 (Lab) (Room No: 507)
  • 02-2789-9123 (Office)
  • 02-2651-0774 (Fax)

Specialty:

Cell biology of viral infections

Virus entry and egress


Education and Positions:
  • Ph.D., University of Zurich

    Postdoc., The University of Tokyo


Virus infection is a dynamic process and highly dependent on the host cells. Our laboratory endeavor to understand how viruses exploit cellular machineries to achieve their infection and replication. We are especially interested in influenza virus, which continuously evolve and bring new epidemics and pandemics to the world.

 

Our research focuses on the late stages of influenza virus and SARS-CoV-2 life cycles, including virion assembly, egress and transmission between cells. These critical steps ensure the formation of infective progeny virions, and release them from the host to establish new infections. We aim to elucidate the virus-host interaction in these infection steps, its kinetics, and the underlying regulatory mechanisms. A special folcus has been put on the roles of intracellular vesicles and cytoskeletons in the scenarios. To resolve the dynamic and complex infection processes, we employ an interdisciplinary approach leveraging tools from molecular virology, cell biology, advanced light/EM microscopy, and computational analyses. We hope that our research will yield new insights into the cell biology of virus infection, and thereby provide a basis for the development of future therapeutics against influenza and COVID.

  1. Sun CP, Chiu CW, Wu PY, Tsung SI, Lee IJ, Hu CW, Hsu MF, Kuo TJ, Lan YH, Chen LY, Ng HY, Chung MJ, Liao HN, Tseng SC, Lo CH, Chen YJ, Liao CC, Chang CS, Liang JJ, Draczkowski P, Puri S, Chang YC, Huang JS, Chen CC, Kau JH, Chen YH, Liu WC, Wu HC, Hsu STD, (Wang IH*), Tao MH* Development of AAV-delivered broadly neutralizing anti-human ACE2 antibodies against SARS-CoV-2 variants Molecular Therapy 31(11), 3322-3336 (2023-11) [JCR] [WOS]
  2. Yang CF*, Liao CC, Hsu HW, Liang JJ, Chang CS, Ko HY, Chang RH, Tang WC, Chang MH, (Wang IH*), Lin YL* Human ACE2 protein is a molecular switch controlling the mode of SARS-CoV-2 transmission Journal of Biomedical Science 30(1), 87 (2023-10-12) [JCR] [WOS]
  3. Lee IJ, Lan YH, Wu PY, Wu YW, Chen YH, Tseng SC, Kuo TJ, Sun CP, Jan JT, Ma HH, Liao CC, Liang JJ, Ko HY, Chang CS, Liu WC, Ko YA, Chen YH, Sie ZL, Tsung SI, Lin YL, (Wang IH), Tao MH A receptor-binding domain-based nanoparticle vaccine elicits durable neutralizing antibody responses against SARS-CoV-2 and variants of concern. Emerging microbes & infections 12(1), 2149353 (2023) [JCR] [WOS]
  4. Lee IJ, Sun CP, Wu PY, Lan YH, (Wang IH), Liu WC, Yuan JPY, Chang YW, Tseng SC, Tsung SI, Chou YC, Kumari M, Lin YS, Chen HF, Chen TY, Lin CC, Chiu CW, Hsieh CH, Chuang CY, Cheng CM, Lin HT, Chen WY, Hsu FF, Hong MH, Liao CC, Chang CS, Liang JJ, Ma HH, Chiang MT, Liao HN, Ko HY, Chen LY, Ko YA, Yu PY, Yang TJ, Chiang PC, Hsu ST, Lin YL, Lee CC, Wu HC, Tao MH* A booster dose of Delta × Omicron hybrid mRNA vaccine produced broadly neutralizing antibody against Omicron and other SARS-CoV-2 variants JOURNAL OF BIOMEDICAL SCIENCE 29, 49 (2022-07-07) [JCR] [WOS]
  5. Sun CP#, Jan JT#, (Wang IH#), Ma HH, Ko HY, Wu PY, Kuo TJ, Liao HN, Lan YH, Sie ZL, Chen YH, Ko YA, Liao CC, Chen LY, Lee IJ, Tsung SI, Lai YJ, Chiang MT, Liang JJ, Liu WC, Wang JR, Yuan JPY, Lin YS, Tsai YC, Hsieh SL, Li CW, Wu HC, Ko TM, Lin YL*, Tao MH* (#Equal Contribution) Rapid generation of mouse model for emerging infectious disease with the case of severe COVID-19 PLOS Pathogens 17(8), e1009758 (2021) [JCR] [WOS]
  6. Zhong G, Fan S, Hatta M, Nakatsu S, Walters KB, Lopes TJS, (Wang J IH), Ozawa M, Karasin A, Li Y, Tong S, Donis RO, Neumann G, Kawaoka Y* Mutations in the Neuraminidase-Like Protein of Bat Influenza H18N11 Virus Enhance Virus Replication in Mammalian Cells, Mice, and Ferrets Journal of Virology 94(5), e01416-19 (2020-03) [JCR] [WOS]
  7. Ueki H, (Wang IH), Zhao D, Gunzer M, Kawaoka Y* Multicolor two-photon imaging of in vivo cellular pathophysiology upon influenza virus infection using the two-photon IMPRESS Nature Protocols 15, 1041–1065 (2020) [JCR] [WOS]
  8. Yasuhara A, Yamayoshi S, Kiso M, Sakai-Tagawa Y, Koga M, Adachi E, Kikuchi T, (Wang IH), Yamada S, Kawaoka Y* Antigenic drift originating from changes to the lateral surface of the neuraminidase head of influenza A virus. Nature microbiology 4(6), 1024-1034 (2019-06) [JCR] [WOS]
  9. (Wang IH), Burckhardt CJ, Yakimovich A, Greber UF* Imaging, Tracking and Computational Analyses of Virus Entry and Egress with the Cytoskeleton. VIRUSES-BASEL 10(4), pii: E166 (2018) [JCR] [WOS]
  10. Ueki H#, (Wang IH#), Fukuyama S, Katsura H, da Silva Lopes TJ, Neumann G, Kawaoka Y* (# Equal contribution) In vivo imaging of the pathophysiological changes and neutrophil dynamics in influenza virus-infected mouse lungs. Proceedings of the National Academy of Sciences of the United States of America 115(28), E6622-E6629 (2018) [JCR] [WOS]

POSTDOC
Ju, Tsai-Kai
Ju, Tsai-Kai
Hsu, Hung-Wei Max
Hsu, Hung-Wei Max
RESEARCH ASSOCIATES
member
Chen, Yu-Chuan
STUDENTS
Wu, Chen-Hui Henry
Wu, Chen-Hui Henry
member
Kuo, Hsin
ALUMNI
Lin, Yan-Chia
Lin, Yan-Chia
Chang, Ming-Hao
Chang, Ming-Hao
Wu, Abe
Wu, Abe
Lin, Pin-Ru
Lin, Pin-Ru
Tsai, Wan-Ju
Tsai, Wan-Ju