Dr. Hsieh, Patrick Ching-Ho 's publons link picture

謝清河博士

特聘研究員
Division Chief
  • 02-27899170 (Lab) (Room No: N417)
  • 02-27858594 (Fax)

Specialty:
  • Stem cells and regenerative medicine
  • Nanoscience and nanomedicine
  • Translational Research

Education and Positions:
  • M.D. Kaohsiung Medical College
    Ph.D. University of Washington, Seattle (Bioengineering)


  • Personal CV

  • 利用誘導性心肌細胞標的基因轉殖鼠進行成鼠心肌細胞血統追蹤,本實驗室發現老鼠在自然老化過程中,原有的心肌細胞並不會藉由幹細胞分化進行新陳代謝。研究卻顯示了令人驚訝的結果,當心肌梗塞發生之後二週內,在梗塞周圍的心肌細胞竟有多達15%左右是由幹細胞衍生而來。證明成年哺乳類動物的心臟可能仍然具有某些再生的能力。本實驗室藉由結合生物、醫學、工程三個領域的轉譯研究,以改進幹細胞在受損心肌中的物理、化學、機械與生物的奈微環境,同時開發新型的奈米生醫材料進行基因轉殖與藥物釋放,以幫助幹細胞形成成熟而有功能的心臟組織,達成真正的心肌再生。近年,本實驗室利用奈米纖維水膠(NF)結合血管內皮生長因子(VEGF)形成NF/VEGF的混合藥物,並注射到受損心肌部位。一方面克服了生長因子單獨使用造成的血管滲漏、致癌等副作用。二方面可提升梗塞後的心功能,減少梗塞面積等。更驚人的是,這個微環境還會引發心肌再生,打破傳統認為心肌無法再生的觀念。

    Our Team
    Team photo

    1. Chen HC, Liu YW, Chang KC, Wu YW, Chen YM, Chao YK, Yu MY, Lundy DJ, CJ, Hsieh ML, Cheng YC, Prajnamitra RP, Lin PJ, Ruan SC, Chen DHK, Shih ESC, Chen KW, Chang SS, Chang CMC, Puntney R, Moy AW, Lee JJ, Wu DC, Hwang MJ, Coonen J, Hacker TA, Yen CLE, Rey FE, Kamp TJ, Hsieh PC* Gut butyrate-producers confer post-infarction cardiac protection Nature Communications 14(1), 7249 (2023-11-09) [JCR] [WOS]
    2. 67.Patrick C Hsieh Metabolic reprogramming in adult cardiomyocytes promotes heart regeneration AHA Scientific Sessions 2023 (2023-11) [JCR] [WOS]
    3. Cheng YC, Hsieh ML, Lin CJ, Chang CMC, Huang CY, Puntney R, Moy AW, Ting CY, Chan DZH, Nicholson MW, Lin PJ, Chen CH, Kim GC, Zhang J, Coonen J, Basu P, Simmons HA, Liu YW, Hacker TA, Kamp TJ, Hsieh PCH* Combined Treatment of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes and Endothelial Cells Regenerate the Infarcted Heart in Mice and Non-Human Primates Circulation 148(18), 1395-1409 (2023-10-31) [JCR] [WOS]
    4. Patrick C Hsieh Metabolic reprogramming in adult cardiomyocytes promotes heart regeneration Cell State Conversions (2023-10) [JCR] [WOS]
    5. Yi-Chan Lee, Yuan-Yuan Cheng, Hsin-Yuan Chien, Shu-Chian Ruan, Po-Ju Lin, Patrick C Hsieh Loss of HMGCS2-mediated Ketogenesis accelerates cardiac aging BCVS 2023 (2023-07) [JCR] [WOS]
    6. Cheng YY, Gregorich Z, Prajnamitra RP, Lundy DJ, Ma TY, Huang YH, Lee YC, Rua SC, Lin JH, Lin PJ, Wen Kuo C, Chen P, Yan YT, Tian R, Kamp TJ, Hsieh PCH* Metabolic Changes Associated With Cardiomyocyte Dedifferentiation Enable Adult Mammalian Cardiac Regeneration Circulation 146, 1950-1967 (2022-12) [JCR] [WOS]
    7. Yuan-Yuan Cheng, Patrick C.H. Hsieh* HMGCS2-mediated Ketogenesis Induces Adult Cardiomyocyte Dedifferentiation and Enables Cardiac Regeneration AHA Scientific Sessions 2022 (2022-11) [JCR] [WOS]
    8. Yu-Che Cheng, Patrick C.H. Hsieh* Injection Of Human IPSC-derived Cardiac Cells Promote Cardiac Repair After Infarction In Nonhuman Primates AHA Scientific Sessions 2022 (2022-11) [JCR] [WOS]
    9. Hung-Chih Chen, Patrick C.H. Hsieh* Post-infarction cardiac protection by gut butyrate-producers AHA Scientific Sessions 2022 (2022-11) [JCR] [WOS]
    10. Lin CJ, Cheng YC, Chen HC, Chao YK, Nicholson MW, Yen ECL, Kamp TJ, Hsieh PC* Commensal gut microbiota-derived acetate and propionate enhance heart adaptation in response to cardiac pressure overload in mice Theranostics 12(17), 7319-7334 (2022-10) [JCR] [WOS]

    - 博士後研究 -
     Chen, Byron
    陳泓志
    - 研究助理 -
     Tang, Tony
    湯文宏
    Lin, Paul Po-Ju
    林伯儒
    Ruan, Papa
    阮淑倩
    Lee, Alice
    李宣穎
    Chang, Chi-En
    張綺恩
    Chien , Hsin-Yuan
    簡新原
    Lee, Monica
    李孟芸
    Tseng, Ching-Fen
    曾靖棻
    Teng, Irene
    鄧艾云
    Huang, Yung-Jui Rick
    黃永睿
    Chang, Leo
    鐘明耀
    Pasaribu, Suminani Novita
    李珠玉
    Luu, Nguyen Ngoc Nguyet
    劉阮玉月
    - 學生 -
    Chen, Jui-Shen
    陳睿生
    Lee, Yi-Chan
    李亦展
    Steward, Theodore
    塔法茲瓦
    - 學術界 -
    Cheng, Bill
    程華強
    Lundy, David
    藍迪尉
     Hsu, Catherine
    徐莞曾
     Cheng, Yuan-Yuan
    鄭媛元
    Lee, Michelle
    李佳蓉
    Prajnamitra, Ray Putra
    張家豪
    - 業界 -
     Huang, Jennifer
    黃瀞瑩
     Chen, Chien-Hsi
    陳建熹
    Chen, Jean
    陳貞云
    Lee, Desy
    李凱詩
    Nicholson, Martin
    申馬丁
    Beh , Chaw Yee
    馬昭瑜
    - 繼續深造就讀 -
     Lee, Keng-Jung
    李庚融
    Chiu, Yueh-Ting (Candice)
    邱樂庭
    Hsu, Chia-Hsin (Cindy)
    許嘉心
    Chao, Yu Kai (Kevin)
    趙昱凱
    You, Min Yi
    游閔亦