Dr. Hsieh, Patrick Ching-Ho
Distinguished Research Fellow
Division Chief
- 02-27899170 (Lab) (Room No: N417)
- 02-27858594 (Fax)
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Specialty:
Education and Positions:
M.D. Kaohsiung Medical College
Ph.D. University of Washington, Seattle (Bioengineering)
As a dedicated physician-scientist and bioengineer, Dr. Hsieh's research endeavors have spanned diverse areas, yielding impactful contributions to cardiovascular regeneration, cancer nanomedicine, microbiota and metabolism, iPSC technologies, and translational research. Some key achievements include:
Cardiovascular regeneration insights: Investigated postnatal cardiomyocyte potential for proliferation, employing isotope-imaging NMR/mass spectrometry, genetic fate-mapping mouse models and human iPSC-derived cardiac cell transplantation in nonhuman primate models to explore novel therapeutic targets for promoting adult cardiomyocyte regeneration after myocardial infarction (MI). (Nat Med 2007, Sci Transl Med 2012, EMBO MM 2014, Circ Res 2015, Circulation 2023)
Cardiomyocyte reprogramming: Explored cardiomyocyte reprogramming into cardiac stem/progenitor cells, identifying a gene cocktail (FoxM1, Id1, Jnk3-shRNA) that induces cardiomyocyte proliferation in vitro and in vivo. Demonstrated improved cardiac function and reduced fibrosis after MI, offering a practical strategy for tissue regeneration. (EMBO MM 2017, Circulation 2022)
Microbiota and cardiac repair: Investigated the role of gut microbiota-derived short-chain fatty acids in post-MI repair in mice, nonhuman primates and patients with ST-elevated MI. Established a link between gut microbiota composition and host immune composition, providing insights for potential modulation of pathological outcomes after MI. (Circulation 2019, Nat Comms 2023)
Nanomedicine innovations: Developed a reloadable multi-drug capturing delivery system for targeted ischemic disease treatment, showcasing the potential for sequential administration of protein drugs in murine and porcine models. This technology has been transferred for further development by a Taiwan-based company. (Circulation 2010, Sci Transl Med 2016)
Blood-brain barrier permeability: Developed a strategy using low-dose VEGF to induce a transient increase in blood-brain barrier permeability, enabling enhanced delivery of nanomedicines for glioblastoma treatment. Demonstrated applicability in mouse models and pigs, showcasing potential clinical translation. (Sci Transl Med 2012, ACS Nano 2019)
Immune cell shuttle for nanotherapeutics: Designed aptamer-based lipid nanovectors that actively bind to monocytes, enabling precise delivery of nanotherapeutics for heart disease and cancer. Successfully treated cardiac ischemia-reperfusion injury and pancreatic ductal adenocarcinoma. (Adv Healthc Mat 2016, Sci Adv 2021)
National iPSC Core leadership: Led Taiwan's national iPSC Core, a collaborative effort involving IBMS, National Taiwan University Hospital, Taipei Veterans General Hospital, National Health Research Institutes, and Food Industry Research and Development Institute for eight years. Generated over 500 human iPSC lines and established the Taiwan iPSC Bank containing 112 human iPSC lines for public use, elevating Taiwan among the top 5 iPSC banks globally. (JBMS 2020, Cell Rep 2022, Circulation 2023)
Our Team
- Sep 09, 2024 Dr. Patrick Hsieh becomes a member of the Healthy Taiwan Promotion Committee, Presidential Office of Taiwan
- Sep 09, 2024 Dr. Patrick Hsieh receives the prestigious TienTe Lee Biopharmaceutical Award 2024.
- Jan 17, 2024 Human Heart Tissue Regeneration in Non-human Primates: A Breakthrough
Journal 121
Book 4
Journal 121 Book 4
- Chen HC, Liu YW, Chang KC, Wu YW, Chen YM, Chao YK, Yu MY, Lundy DJ, CJ, Hsieh ML, Cheng YC, Prajnamitra RP, Lin PJ, Ruan SC, Chen DHK, Shih ESC, Chen KW, Chang SS, Chang CMC, Puntney R, Moy AW, Lee JJ, Wu DC, Hwang MJ, Coonen J, Hacker TA, Yen CLE, Rey FE, Kamp TJ, Hsieh PC* Gut butyrate-producers confer post-infarction cardiac protection. Nature Communications 14(1), 7249 (2023-11-09) [JCR] [WOS]
- 67.Patrick C Hsieh Metabolic reprogramming in adult cardiomyocytes promotes heart regeneration. AHA Scientific Sessions 2023 (2023-11) [JCR] [WOS]
- Cheng YC, Hsieh ML, Lin CJ, Chang CMC, Huang CY, Puntney R, Moy AW, Ting CY, Chan DZH, Nicholson MW, Lin PJ, Chen CH, Kim GC, Zhang J, Coonen J, Basu P, Simmons HA, Liu YW, Hacker TA, Kamp TJ, Hsieh PCH* Combined Treatment of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes and Endothelial Cells Regenerate the Infarcted Heart in Mice and Non-Human Primates. Circulation 148(18), 1395-1409 (2023-10-31) [JCR] [WOS]
- Patrick C Hsieh Metabolic reprogramming in adult cardiomyocytes promotes heart regeneration. Cell State Conversions (2023-10) [JCR] [WOS]
- Yi-Chan Lee, Yuan-Yuan Cheng, Hsin-Yuan Chien, Shu-Chian Ruan, Po-Ju Lin, Patrick C Hsieh Loss of HMGCS2-mediated Ketogenesis accelerates cardiac aging. BCVS 2023 (2023-07) [JCR] [WOS]
- Cheng YY, Gregorich Z, Prajnamitra RP, Lundy DJ, Ma TY, Huang YH, Lee YC, Rua SC, Lin JH, Lin PJ, Wen Kuo C, Chen P, Yan YT, Tian R, Kamp TJ, Hsieh PCH* Metabolic Changes Associated With Cardiomyocyte Dedifferentiation Enable Adult Mammalian Cardiac Regeneration. Circulation 146, 1950-1967 (2022-12) [JCR] [WOS]
- Yuan-Yuan Cheng, Patrick C.H. Hsieh* HMGCS2-mediated Ketogenesis Induces Adult Cardiomyocyte Dedifferentiation and Enables Cardiac Regeneration. AHA Scientific Sessions 2022 (2022-11) [JCR] [WOS]
- Yu-Che Cheng, Patrick C.H. Hsieh* Injection Of Human IPSC-derived Cardiac Cells Promote Cardiac Repair After Infarction In Nonhuman Primates. AHA Scientific Sessions 2022 (2022-11) [JCR] [WOS]
- Hung-Chih Chen, Patrick C.H. Hsieh* Post-infarction cardiac protection by gut butyrate-producers. AHA Scientific Sessions 2022 (2022-11) [JCR] [WOS]
- Lin CJ, Cheng YC, Chen HC, Chao YK, Nicholson MW, Yen ECL, Kamp TJ, Hsieh PC* Commensal gut microbiota-derived acetate and propionate enhance heart adaptation in response to cardiac pressure overload in mice. Theranostics 12(17), 7319-7334 (2022-10) [JCR] [WOS]
- POSTDOC -
Chen, Byron
Wissel , Emily
Wei, Ke-Hsuan
Liu, Cheng-Hao
- RESEARCH ASSOCIATES -
Tang, Tony
Lin, Paul Po-Ju
Ruan, Papa
Lee, Alice
Chang, Chi-En
Chien , Hsin-Yuan
Lee, Monica
Tseng, Ching-Fen
Teng, Irene
Huang, Yung-Jui Rick
Chang, Leo
Pasaribu, Suminani Novita
Luu, Nguyen Ngoc Nguyet
- STUDENTS -
Chen, Jui-Shen
Lee, Yi-Chan
Steward, Theodore
Ullah , Kiramat
- ACADEMIA -
Cheng, Bill
Lundy, David
Hsu, Catherine
Cheng, Yuan-Yuan
Lee, Michelle
Prajnamitra, Ray Putra
- INDUSTRY -
Huang, Jennifer
Chen, Chien-Hsi
Chen, Jean
Lee, Desy
Nicholson, Martin
Beh , Chaw Yee
- OVERSEA GRADUATE STUDY -
Lee, Keng-Jung
Chiu, Yueh-Ting (Candice)
Hsu, Chia-Hsin (Cindy)
Chao, Yu Kai (Kevin)
You, Min Yi
- 2022 Highlight of Significant Research Achievements, Academia Sinica
- 2021 Project for MoST Research Fellow, Ministry of Science and Technology (MoST), Taiwan
- 2021 Distinguished Alumnus Award, Kaohsiung Medical University, Taiwan
- 2020 Healthy Longevity Global Grand Challenge Competition, National Academy of Medicine, NAM
- 2018 Highlight of Significant Research Achievements, Academia Sinica
- 2018 Project for MoST Research Fellow, Ministry of Science and Technology (MoST), Taiwan
- 2017 TECO Award, TECO Technology Foundation, Taiwan
- 2017 World Leading Young Scientist, Society of Polymer Science, Japan
- 2016 Highlight of Significant Research Achievements, Academia Sinica
- 2016 Extramural Grant Award, National Heath Research Institutes (NHRI), Taiwan
- 2015 Highlight of Significant Research Achievements, Academia Sinica
- 2015 Outstanding Research Award, Ministry of Science and Technology (MoST), Taiwan
- 2014 Chair in Biotechnology, Taiwan Bio-Development Foundation (TBF), Taiwan
- 2013 Best paper in 2012, National Cheng Kung University College of Medicine, Tainan, Taiwan
- 2013 International Fellow of American Heart Association (FAHA), Council on Basic Cardiovascular Sciences
- 2013 Top translational researcher in 2012, ranked top 1 in assistant/associate professors, Nature Biotechnology
- 2013 National Innovation Award, Institute of Biotechnology and Medicine Industry, Taiwan
- 2012 Outstanding Research Award, National Science Council, Taiwan
- 2012 Annual Conference Travel Award & Poster Competition Judge, International Society for Stem Cell Research, Yokohama, Japan
- 2011 National Innovation Award, Institute of Biotechnology and Medicine Industry, Taiwan