Dr. Liu, Fu-Tong 's publons link picture

劉扶東博士

通信研究員
中央研究院院士
  • 02-2652-3056 (Office)

Specialty:
  • Galectins
  • Allergic Inflammation
  • Immune-mediated dermatoses

Education and Positions:
    • Ph.D. University of Chicago
    • M.D. University of Miami, School of Medicine

我們的研究著重於探究動物凝集素成員之一的半乳糖凝集素,在炎症、先天免疫、癌症與肥胖方面的功能。在炎症的領域,我們正在研究的半乳糖凝集素-3、-7和-8在皮膚炎症所扮演的角色,研究重點是角質細胞如何調控細胞因子和趨化因子的生合成。在先天免疫方面,我們正在研究(一)半乳糖凝集素-3對逆轉錄病毒的傳輸和流感病毒的感染和(二)在胃腸道的半乳糖凝集素-8和-9於宿主和病原體之間相互作用所扮演的角色。在癌症方面,我們的研究重點是半乳糖凝集素-3和-7在皮膚癌的角色。在肥胖的領域,我們專注於半乳糖凝集素-12的研究。此外,我們致力於透過研究細胞質內的半乳糖凝集素與暴露在細胞內損壞的胞器上之的糖基結合,來研究半乳糖凝集素的細胞內功能。我們也致力於開發半乳糖凝集素-3的抑製劑,用於炎性疾病和癌症的治療,以及半乳糖凝集素-12的抑製劑,用於針對脂肪組織來達到降低肥胖的目的。

Our Team
Team photo

期刊 372 專書 17

  1. Merleev, A.A., Le, S.T., Alexanian, C., Toussi, A., Xie, Y., Marusina, A.I., Watkins, S.M., Patel, F., Billi, A.C., Wiedemann, J., Izumiya, Y., Kumar, A., Uppala, R., Kahlenberg, J.M., Liu, F.-T., Adamopoulos, I.E., Wang, E.A., Ma, C., Cheng, M.Y, Xiong, H., Kirane, A., Luxardi, G., Andersen, B., Tsoi, L.C., Lebrilla, C.B., Gudjonsson, J.E., Maverakis, E. Biogeographic and disease-specific alterations in epidermal lipid composition and single-cell analysis of acral keratinocytes. JCI Insight 7(16), e159762 (2022) [JCR] [WOS]
  2. Richard D. Cummings, Fu-Tong Liu, Gabriel A. Rabinovich, Sean R. Stowell, and Gerardo R. Vasta Chapter 36 Galectins. Essentials of Glycobiology CHAPTER 36 (PAGE 1-14) (2022) [JCR] [WOS]
  3. Wang, S.-F., Hung, Y.-H., Tsao, C.-H., Chiang, C.-Y., Teoh, P.-G., Chiang, M.-L., Lin, W.-H., Hsu, D.K., Lin, H-C., Lin, C.-H., Liu, F.-T., Chen, H.-Y Galectin-3 facilitates cell-to-cell HIV-1 transmission by altering the composition of membrane lipid rafts in CD4 T cells. GLYCOBIOLOGY 32 (9), 760-777 (2022) [JCR] [WOS]
  4. Hong, M.-H., Weng, I.-C., Li, F.-Y., Liu, F.-T. Visualization of cytosolic galectin accumulation around damaged vesicles and organelles. Galectins: Methods and Protocols, Methods in Molecular Biology 2442, 353-365 (2022) [JCR] [WOS]
  5. Ip PP, Li Q, Lin WH, Chang CC, Fann CS, Chen HY, Liu FT, Lebrilla CB, Yang CC, Liao F Analysis of site-specific glycan profiles of serum proteins in patients with multiple sclerosis or neuromyelitis optica spectrum disorder-a pilot study.. Glycobiology 31(9), 1230-1238 (2021) [JCR] [WOS]
  6. Kelel Musin, Yang Ruey-Bing, Tsai Tsen-Fang, Liang Pi-Hui, Wu Fu-Yu, Huang Yu-Tien, Yang Ming-Fong, Hsiao Yu-Ping, Wang Li-Fang, Tu Chen-Fen, Liu Fu-Tong, Lee Yungling L. FUT8 Remodeling of EGFR Regulates Epidermal Keratinocyte Proliferation during Psoriasis Development. Journal of Investigative Dermatology 141, 512-522 (2021) [JCR] [WOS]
  7. Chiang Ming-Tsai, Chen I-Ming, Hsu Fu-Fei, Chen Yen-Hui, Tsai Min-Shao, Hsu Yaw-Wen, Leu Hsin-Bang, Huang Po-Hsun, Chen Jaw-Wen, Liu Fu-Tong, Chen Ying-Hwa, Chau Lee-Young Gal-1 (Galectin-1) Upregulation Contributes to Abdominal Aortic Aneurysm Progression by Enhancing Vascular Inflammation. Arteriosclerosis, Thrombosis, and Vascular Biology 41, 331-345 (2021) [JCR] [WOS]
  8. Tsao CH, Hsieh WC, Yang RY, Lo YH, Tu TJ, Ke LY, Zouboulis CC, Liu FT Galectin-12 modulates sebocyte proliferation and cell cycle progression by regulating cyclin A1 and CDK2.. Glycobiology to be added, to be added (2021) [JCR] [WOS]
  9. Lo TH, Chen HL, Yao CI, Weng IC, Li CS, Huang CC, Chen NJ, Lin CH, Liu FT Galectin-3 promotes noncanonical inflammasome activation through intracellular binding to lipopolysaccharide glycans.. Proceedings of the National Academy of Sciences of the United States of America 118(30), e2026246118 (2021) [JCR] [WOS]
  10. Chen Hung-Lin, Lo Chia-Hui, Huang Chi-Chun, Lu Meng-Ping, Hu Po-Yuan, Chen Chang-Shan, Chueh Di-Yen, Chen Peilin, Lin Teng-Nan, Lo Yuan-Hsin, Hsiao Yu-Ping, Hsu Daniel K., Liu Fu-Tong Galectin-7 downregulation in lesional keratinocytes contributes to enhanced IL-17A signaling and skin pathology in psoriasis. Journal of Clinical Investigation 131(1), e130740 (2021) [JCR] [WOS]