Dr. Liu, Fu-Tong 's publons link picture

Dr. Liu, Fu-Tong

Corresponding Research Fellow
Academician, Academia Sinica
  • 02-2652-3056 (Office)

  • Galectins
  • Allergic Inflammation
  • Immune-mediated dermatoses

Education and Positions:
    • Ph.D. University of Chicago
    • M.D. University of Miami, School of Medicine

Our research is focused on the investigation of the functions of a family of animal lectins, galectins, in inflammation, innate immunity, and cancer.  In the area of inflammation, we are studying the roles of galectin -7 and -8 in skin inflammatory diseases, by focusing on their regulation of proliferation of keratinocytes, as well as cytokine and chemokine production by these cells. We are also investigating the role of galectin-12 in skin inflammation through its function in sebaceous glands.  In the area of innate immunity, we are focusing on the roles of galectin-4 and -9 in host-pathogen interactions in the gastrointestinal tract.  Intracellular galectins are now known to bind to glycans exposed to the cytosol when intracellular organelles are damaged.  We are studying this process in relationship to the role of galectins in innate immunity, inflammation, and cancer. 

Our Team
Team photo

Journal 317 Book 14

  1. Merleev, A.A., Le, S.T., Alexanian, C., Toussi, A., Xie, Y., Marusina, A.I., Watkins, S.M., Patel, F., Billi, A.C., Wiedemann, J., Izumiya, Y., Kumar, A., Uppala, R., Kahlenberg, J.M., Liu, F.-T., Adamopoulos, I.E., Wang, E.A., Ma, C., Cheng, M.Y, Xiong, H., Kirane, A., Luxardi, G., Andersen, B., Tsoi, L.C., Lebrilla, C.B., Gudjonsson, J.E., Maverakis, E. Biogeographic and disease-specific alterations in epidermal lipid composition and single-cell analysis of acral keratinocytes JCI Insight 7(16), e159762 (2022) [JCR] [WOS]
  2. Richard D. Cummings, Fu-Tong Liu, Gabriel A. Rabinovich, Sean R. Stowell, and Gerardo R. Vasta Chapter 36 Galectins Essentials of Glycobiology CHAPTER 36 (PAGE 1-14) (2022) [JCR] [WOS]
  3. Wang, S.-F., Hung, Y.-H., Tsao, C.-H., Chiang, C.-Y., Teoh, P.-G., Chiang, M.-L., Lin, W.-H., Hsu, D.K., Lin, H-C., Lin, C.-H., Liu, F.-T., Chen, H.-Y Galectin-3 facilitates cell-to-cell HIV-1 transmission by altering the composition of membrane lipid rafts in CD4 T cells GLYCOBIOLOGY 32 (9), 760-777 (2022) [JCR] [WOS]
  4. Hong, M.-H., Weng, I.-C., Li, F.-Y., Liu, F.-T. Visualization of cytosolic galectin accumulation around damaged vesicles and organelles Galectins: Methods and Protocols, Methods in Molecular Biology 2442, 353-365 (2022) [JCR] [WOS]
  5. Ip PP, Li Q, Lin WH, Chang CC, Fann CS, Chen HY, Liu FT, Lebrilla CB, Yang CC, Liao F Analysis of site-specific glycan profiles of serum proteins in patients with multiple sclerosis or neuromyelitis optica spectrum disorder-a pilot study. Glycobiology 31(9), 1230-1238 (2021) [JCR] [WOS]
  6. Kelel Musin, Yang Ruey-Bing, Tsai Tsen-Fang, Liang Pi-Hui, Wu Fu-Yu, Huang Yu-Tien, Yang Ming-Fong, Hsiao Yu-Ping, Wang Li-Fang, Tu Chen-Fen, Liu Fu-Tong, Lee Yungling L. FUT8 Remodeling of EGFR Regulates Epidermal Keratinocyte Proliferation during Psoriasis Development Journal of Investigative Dermatology 141, 512-522 (2021) [JCR] [WOS]
  7. Chiang Ming-Tsai, Chen I-Ming, Hsu Fu-Fei, Chen Yen-Hui, Tsai Min-Shao, Hsu Yaw-Wen, Leu Hsin-Bang, Huang Po-Hsun, Chen Jaw-Wen, Liu Fu-Tong, Chen Ying-Hwa, Chau Lee-Young Gal-1 (Galectin-1) Upregulation Contributes to Abdominal Aortic Aneurysm Progression by Enhancing Vascular Inflammation Arteriosclerosis, Thrombosis, and Vascular Biology 41, 331-345 (2021) [JCR] [WOS]
  8. Tsao CH, Hsieh WC, Yang RY, Lo YH, Tu TJ, Ke LY, Zouboulis CC, Liu FT Galectin-12 modulates sebocyte proliferation and cell cycle progression by regulating cyclin A1 and CDK2. Glycobiology to be added, to be added (2021) [JCR] [WOS]
  9. Lo TH, Chen HL, Yao CI, Weng IC, Li CS, Huang CC, Chen NJ, Lin CH, Liu FT Galectin-3 promotes noncanonical inflammasome activation through intracellular binding to lipopolysaccharide glycans. Proceedings of the National Academy of Sciences of the United States of America 118(30), e2026246118 (2021) [JCR] [WOS]
  10. Chen Hung-Lin, Lo Chia-Hui, Huang Chi-Chun, Lu Meng-Ping, Hu Po-Yuan, Chen Chang-Shan, Chueh Di-Yen, Chen Peilin, Lin Teng-Nan, Lo Yuan-Hsin, Hsiao Yu-Ping, Hsu Daniel K., Liu Fu-Tong Galectin-7 downregulation in lesional keratinocytes contributes to enhanced IL-17A signaling and skin pathology in psoriasis Journal of Clinical Investigation 131(1), e130740 (2021) [JCR] [WOS]