牟昀博士
長聘副研究員
- 2789-9035 (Lab) (Room No: N721)
- 2652-3009 (Office)
-
Specialty:
- Computational protein design
- Antibody engineering
- Immunotherapy
- Cancer proteomics
- CRISPR screening
Education and Positions:
- B.S. National Taiwan University
- M.S. National Taiwan University
- Ph.D. California Institute of Technology
- Postdoc. University of California, San Francisco
本實驗室目前專注於開發可應用於癌症療法的基因改造工程技術及藥物，來誘發人體免疫反應以對抗腫瘤細胞生長(免疫療法)。我們發展四種不同材料的生物製劑—蛋白質、病毒(基因療法)、生物奈米顆粒、及細菌—來對癌症做治療：
(一) 新型蛋白質療法：我們藉由最新穎的技術—電腦模擬計算設計、定向進化蛋白質工程、嗜菌體/酵母菌呈現系統—製造出改良的抗體/奈米抗體、細胞激素、CRISPR/Cas9 等蛋白質，以期達到更佳的療效。
(二) 病毒為載體的基因療法：我們開發利用嗜菌體做為基因療法的載體，可達到低成本、高產量、同時可設計針對特定細胞進行感染的優點。
(三) 生物奈米顆粒：經細菌產生出的奈米顆粒—外膜囊泡 (Outer membrane vesicles)—對腫瘤組織有極佳的標靶能力，且具有高度免疫激發性及抗腫瘤活性。細菌外膜囊泡可藉由簡單的質體轉形達到對奈米顆粒的修飾以此增加其療效。
(四) 細菌療法：文獻上已知有一些品系的細菌(包含大腸桿菌)可選擇性地於腫瘤組織進行共生。我們利用此一特性使改造過的細菌成為活體工廠，持續性地於腫瘤組織分泌具抗腫瘤活性的分子。
實驗室至今已成功利用以上數種療法將小鼠生長的腫瘤完全治癒。未來將持續改良我們的藥物設計，應用在更多的小鼠腫瘤模型中或是更高等的哺乳動物。
期刊 39
專書 0
期刊 39 專書 0
- Tang Wen-Hung, Wang Shi-Han, Wang Chiu-Feng, Mou Yun, Lin Min-Guan, Hsiao Chwan-Deng, Liao You-Di The lipid components of high-density lipoproteins (HDL) are essential for the binding and transportation of antimicrobial peptides in human serum. Scientific Reports (2022) [JCR] [WOS]
- Hu Che-Wei, Chang You-Chiun, Liu Cheng-Hao, Yu Yao-An, Mou Kurt Yun Development of a TNF-α-mediated Trojan Horse for bacteria-based cancer therapy. Molecular Therapy 30(7), 2522-2536 (2022) [JCR] [WOS]
- Lin Wen-Ching, Tang Hao-Cheng, Wang Han Ying, Kao Chia-Yi, Chang You-Chiun, Li Athena Hsu, Yang Shi-Bing, Mou Kurt Yun Fragment-Directed Random Mutagenesis by the Reverse Kunkel Method. ACS Synthetic Biology 11(4), 1658-1668 (2022) [JCR] [WOS]
- Wang Han Ying, Chang You-Chiun, Hu Che-Wei, Kao Chia-Yi, Yu Yao-An, Lim See-Khai, Mou Kurt Yun Development of a Novel Cytokine Vehicle Using Filamentous Phage Display for Colorectal Cancer Treatment. ACS Synthetic Biology 10(8), 2087-2095 (2021) [JCR] [WOS]
- Chen Wentao, Mou Kurt Yun, Solomon Paige, Aggarwal Rahul, Leung Kevin K., Wells James A. Large remodeling of the Myc-induced cell surface proteome in B cells and prostate cells creates new opportunities for immunotherapy. Proceedings of the National Academy of Sciences 118(4), e2018861118 (2021) [JCR] [WOS]
- Liu Cheng-Hao, Chang Jen-Hsuan, Chang You-Chiun, (Mou Kurt Yun*) Treatment of murine colitis by Saccharomyces boulardii secreting atrial natriuretic peptide. Journal of Molecular Medicine 98(12),1675-1687 (2020-12) [JCR] [WOS]
- Huang Meng‐Sen, Chang Jen‐Hsuan, Lin Wen‐Ching, Cheng Yu‐Hsiang, Li Fu‐An, Suen Ching‐Shu, Hwang Ming‐Jing, Chang Chung‐ke*, (Mou Kurt Yun*) SLC38A2 Overexpression Induces a Cancer‐like Metabolic Profile and Cooperates with SLC1A5 in Pan‐cancer Prognosis. Chemistry – An Asian Journal 15(22),3861-3872 (2020-11) [JCR] [WOS]
- Zhou Xin X., Bracken Colton J., Zhang Kaihua, Zhou Jie, (Mou Yun), Wang Lei, Cheng Yifan, Leung Kevin K., Wells James A. Targeting Phosphotyrosine in Native Proteins with Conditional, Bispecific Antibody Traps. Journal of the American Chemical Society 142(41),17703-17713 (2020-10) [JCR] [WOS]
- Liu Cheng-Hao, Chien Ming-Jou, Chang You-Chiun, Cheng Yu-Hsiang, Li Fu-An, (Mou Kurt Yun*) Combining Proximity Labeling and Cross-Linking Mass Spectrometry for Proteomic Dissection of Nuclear Envelope Interactome. Journal of Proteome Research 19(3) 1109-1118 (2020-03) [JCR] [WOS]
- Chang You-Chiun, Kao Chia-Yi, Tang Hao-Cheng, Huang Meng-Sen, (Mou Kurt Yun*) Direct Antibody Isolation on Cells Using Affinity-Tag-Guided Proximity Selection. Biochemistry 59(440), 4285-4293 (2020) [JCR] [WOS]
- 博士後研究 -
林世凱
- 研究助理 -
林文晴
胡哲瑋
潘鐿中
- 學生 -
高嘉宜
張佑群
劉程豪
李姿潔
黃信偉
于耀安
陳美意
吳婉慈
連婉汝
鄭庭葦
蕭伊翔
- 訪問學人 -
吳孟芸
- 昔日夥伴 -
湯皓程
何佳珞
簡明柔
張仁瑄
黃孟森
汪含穎
