Dr. Lee, Yu-Ru 's publons link picture

李育儒博士

助研究員

Specialty:
  • Cancer Genetics
  • Cancer Signaling, Post-translational Modifications, Non-coding RNAs
  • Cancer Biology, Targeted/Immunotherapy

Education and Positions:
    • Ph.D., Institute of Molecular Medicine, National Taiwan University College of Medicine
    • Instructor in BIDMC, Harvard Medical School
    • Post-doc in BIDMC, Harvard Medical School

我實驗室的研究主要著重在這幾個領域,包括泛素化、癌症信號傳導,腫瘤生物學、非編碼RNA、CRISPR 高通量篩選和標靶/免疫療法, 以其找到有效治療多種癌症的方法,包括三陰性乳腺癌、結腸癌、前列腺癌和肝癌。我們將利用全基因組的高通量篩選平台來找尋哪些編碼或者非編碼的基因是對於癌症發展的關鍵分子。除此之外,我們也會結合完善的生化、細胞、基因工程小鼠模型(GEMM)以及類器官 (Patient-Derived Tumorids)等多方面嶄新的方法來探討這新基因在癌症發展中所扮演的功能及分子機制。透過這些方法使我們能夠在全基因組水平上評估這些新基因的功能。通過了解這些編碼基因/非編碼基因在腫瘤發展過程中之調控以及功能,不僅將有助於增加我們對癌症發展的認識,而且還將提供基於編碼或基於RNA的標靶/免疫療法的新策略。我們的最終目標是將所有這些研究都轉譯到臨床治療上,以期造福癌症病人。

Our Team
Team photo

期刊 18 專書 0

  1. Xiao X, Shi J, He C, Bu X, Sun Y, Gao M, Xiang B, Xiong W, Dai P, Mao Q, Xing X, Yao Y, Yu H, Xu G, Li S, Ren Y, Chen B, Jiang C, Meng G, (Lee YR), Wei W, Freeman GJ, Xie C, Zhang J ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy. Nature communications 14(1), 2859 (2023) [JCR] [WOS]
  2. Zhang T, Xu D, Trefts E, Lv M, Inuzuka H, Song G, Liu M, Lu J, Liu J, Chu C, Wang M, Wang H, Meng H, Liu H, Zhuang Y, Xie X, Dang F, Guan D, Men Y, Jiang S, Jiang C, Dai X, Liu J, Wang Z, Yan P, Wang J, Tu Z, Babuta M, Erickson E, Hillis AL, Dibble CC, Asara JM, Szabo G, Sicinski P, Miao J, (Lee YR), Pan L, Shaw RJ, Yuan J, Wei W Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. Science (New York, N.Y.) 380(6652), 1372-1380 (2023) [JCR] [WOS]
  3. Zhang T, Xu D, Liu J, Wang M, Duan LJ, Liu M, Meng H, Zhuang Y, Wang H, Wang Y, Lv M, Zhang Z, Hu J, Shi L, Guo R, Xie X, Liu H, Erickson E, Wang Y, Yu W, Dang F, Guan D, Jiang C, Dai X, Inuzuka H, Yan P, Wang J, Babuta M, Lian G, Tu Z, Miao J, Szabo G, Fong GH, Karnoub AE, (Lee YR), Pan L, Kaelin WG Jr, Yuan J, Wei W Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation. Nature cell biology Jul 3., Jul 3.-Jul 3. (2023) [JCR] [WOS]
  4. Lee JD, Paulo JA, Posey RR, Mugoni V, Kong NR, Cheloni G, (Lee YR), Slack FJ, Tenen DG, Clohessy JG, Gygi SP, Pandolfi PP Dual DNA and protein tagging of open chromatin unveils dynamics of epigenomic landscapes in leukemia. Nature methods 18(3), 293–302 (2021) [JCR] [WOS]
  5. Kishikawa T, Higuchi H, Wang L, Panch N, Maymi V, Best S, Lee S, Notoya G, Toker A, Matesic LE, Wulf GM, Wei W, Otsuka M, Koike K, Clohessy JG, Lee YR, Pandolfi PP WWP1 inactivation enhances efficacy of PI3K inhibitors while suppressing their toxicities in breast cancer models. The Journal of clinical investigation 131(24), e140436-e140436 (2021) [JCR] [WOS]
  6. Lee YR, Pandolfi PP PTEN Mouse Models of Cancer Initiation and Progression. Cold Spring Harbor perspectives in medicine 10(2), a037283-a037283 (2020) [JCR] [WOS]
  7. Lee YR, Yehia L, Kishikawa T, Ni Y, Leach B, Zhang J, Panch N, Liu J, Wei W, Eng C, Pandolfi PP WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition. The New England journal of medicine 382(22), 2103-2116 (2020) [JCR] [WOS]
  8. Zhang J#, Lee YR#, Dang F, Gan W, Menon AV, Katon JM, Hsu CH, Asara JM, Tibarewal P, Leslie NR, Shi Y, Pandolfi PP, Wei W. #Co-first author PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage. CANCER DISCOVERY 9(9), 1306-1323 (2019) [JCR] [WOS]
  9. Lee YR, Chen M, Lee JD, Zhang J, Lin SY, Fu TM, Chen H, Ishikawa T, Chiang SY, Katon J, Zhang Y, Shulga YV, Bester AC, Fung J, Monteleone E, Wan L, Shen C, Hsu CH, Papa A, Clohessy JG, Teruya-Feldstein J, Jain S, Wu H, Matesic L, Chen RH, Wei W, Pandolfi PP Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. Science (New York, N.Y.) 364(6441), aau0159-aau0159 (2019) [JCR] [WOS]
  10. Chen M, Zhang J, Sampieri K, Clohessy JG, Mendez L, Gonzalez-Billalabeitia E, Liu XS, Lee YR, Fung J, Katon JM, Menon AV, Webster KA, Ng C, Palumbieri MD, Diolombi MS, Breitkopf SB, Teruya-Feldstein J, Signoretti S, Bronson RT, Asara JM, Castillo-Martin M, Cordon-Cardo C, Pandolfi PP An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer. Nature genetics 50(2), 206-218 (2018) [JCR] [WOS]

- 博士後研究 -
Chen, Hsin-Yi
陳歆宜
Lim, Syer Choon
林學俊
- 研究助理 -
Chi, Hsin-Hui
紀欣慧
member
阮玄妝
- 學生 -
Chiu, Chun-Nen
邱俊能
Ong, Ann-Zhi
 Ruiz, Liza  González
- 訪問學人 -
Hsiung, En
熊恩
- 昔日夥伴 -
Vu, Thu-Thuy (Julie)
王瑟武
Chang, Chi-Sheng
張啟勝
Hsu, Tsai-Fan
徐采蘩
Huang, Yao-Shen
黃耀燊
member
Lim Chai Ling
Hu, Chen
胡蓁

 

  • Li Foundation Heritage Prize for "Excellence in Creativity" (2021)
  • Academia Sinica Career Development Award (2021)
  • Special outstanding talent award from the Ministry of Science and Technology (延攬特殊優秀人才)
  • Investigator Fellowship from Academia Sinica (新聘學術研究獎)
  • DOD Post-Doc Training Award (W81XWH-16-1-0249), USA, 2016
  • Postdoctoral Research Abroad Program Fellowship, Taiwan National Science Council (NSC) (2014-2016)
  • The Excellent Research Paper Award from Dr. Tien-Te Lee’s Biomedical Foundation (2011) (李天德傑出論文獎)
  • Poster Presentation Distinguished Achievement Award, the 19th Symposium on Recent Advances in Cellular and Molecular Biology (2011)
  • Poster Presentation Distinguished Achievement Award, the 20th Federation of Asia and Oceanian Biochemists and Molecular Biologists (FAOBMB) conferences (2008)