陳垣崇博士
通信研究員
中央研究院院士
- 02-27899081 (Lab) (Room No: N807)
- 02-27899085 (Fax)
-
Specialty:
- Human Genetics
- Genomic Medicine
Education and Positions:
M.D., Ph.D. Columbia University
Highlight Detail
Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome.
Dr. Chen, Yuan-Tsong
J Allergy Clin Immunol., Sep 14, 2011Stevens-Johnson syndrome (SJS) and its related disease, toxic epidermal necrolysis (TEN), are life-threatening drug hypersensitivities with robust immune responses to drugs. Despite the strong HLA predisposition to drug hypersensitivities, such as HLA-B∗1502 to carbamazepine (CBZ)-induced SJS/TEN, it remains unknown whether particular T-cell receptors (TCRs) participate in recognition of small drug/peptide-HLA complexes.