陳垣崇博士

通信研究員
中央研究院院士
  • 02-27899081 (Lab) (Room No: N807)
  • 02-27899085 (Fax)

Specialty:
  • Human Genetics
  • Genomic Medicine

Education and Positions:
  • M.D., Ph.D. Columbia University


Highlight Detail
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Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome.

Dr. Chen, Yuan-Tsong
J Allergy Clin Immunol., Sep 14, 2011

Stevens-Johnson syndrome (SJS) and its related disease, toxic epidermal necrolysis (TEN), are life-threatening drug hypersensitivities with robust immune responses to drugs. Despite the strong HLA predisposition to drug hypersensitivities, such as HLA-B∗1502 to carbamazepine (CBZ)-induced SJS/TEN, it remains unknown whether particular T-cell receptors (TCRs) participate in recognition of small drug/peptide-HLA complexes.