陳垣崇博士

通信研究員
中央研究院院士
  • 02-27899081 (Lab) (Room No: N807)
  • 02-27899085 (Fax)
Specialty:
  • Human Genetics
  • Genomic Medicine
Education and Positions:

  • M.D., Ph.D. Columbia University

Highlight Detail
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Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis.

Dr. Chen, Yuan-Tsong
Nature Medicine., Nov 23, 2008

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening adverse drug reactions characterized by massive epidermal necrosis, in which the specific danger signals involved remain unclear. Here we show that blister cells from skin lesions of SJS-TEN primarily consist of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells, and both blister fluids and cells were cytotoxic.

Journal Link
Dr. Chen, Yuan-Tsong 's Lab