施修明博士
研究員
- 2789-9060 (Lab) (Room No: N605)
- 2652-3520 (Office)
- 2782-7654 (Fax)
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Specialty:
- Protein-protein Interaction & Modification
- Cancer Cell Signaling
- Transcriptional Control
Education and Positions:
Ph.D. Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota
Highlight Detail
HIC1 interacts with and modulates the activity of STAT3.
Dr. Shih, Hsiu-Ming
Cell Cycle., Jun 21, 2013Abstract: HIC1 (hypermethylated in cancer 1) is a tumor suppressor gene, expression of which is frequently suppressed in human cancers. Very little is known about the molecular basis of HIC1 in antagonizing oncogenic pathways. Here, we report that HIC1 forms complexes with the signal transducers and activators of transcription 3 (STAT3) and attenuates STAT3-mediated transcription.