唐堂博士
副院長
特聘研究員
中央研究院院士
- 02-27899156(lab) (Lab) (Room No: 301)
- 02-26523901(o)
- 02-27829143 (Fax)
-
Specialty:
- Centrosome and Cilia Biogenesis
- Mitosis
- Neural Stem Cell Division
Education and Positions:
Ph.D. Human Genetics, Yale University
Highlight Detail
Human microcephaly protein CEP135 binds to hSAS-6 and CPAP, and is required for centriole assembly.
Dr. Tang, Tang K.
EMBO J., Mar 19, 2013Centrioles are cylindrical structures that are usually composed of nine triplets of microtubules (MTs) organized around a cartwheel-shaped structure. Recent studies have proposed a structural model of the SAS-6-based cartwheel, yet we do not know the molecular detail of how the cartwheel participates in centriolar MT assembly.