唐堂博士
副院長
特聘研究員
中央研究院院士
- 02-27899156(lab) (Lab) (Room No: 301)
- 02-26523901(o)
- 02-27829143 (Fax)
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Specialty:
- Centrosome and Cilia Biogenesis
- Mitosis
- Neural Stem Cell Division
Education and Positions:
Ph.D. Human Genetics, Yale University
Highlight Detail
CEP120 interacts with CPAP and positively regulates centriole elongation.
Dr. Tang, Tang K.
JCB., Jul 15, 2013Centriole duplication begins with the formation of a single procentriole next to a preexisting centriole. CPAP (centrosomal protein 4.1–associated protein) was previously reported to participate in centriole elongation. Here, we show that CEP120 is a cell cycle–regulated protein that directly interacts with CPAP and is required for centriole duplication. CEP120 levels increased gradually from early S to G2/M and decreased significantly after mitosis.