Dr. Chen, Chien-Chang 's orcid link picture Dr. Chen, Chien-Chang 's publons link picture



  • Chronic Pain
  • Calcium Channel
  • Cardiovascular Disease

Education and Positions:
  • Ph.D., University of Illinois, Urbana-Champaign

Highlight Detail

Quantitative phosphoproteomic study of pressure-overloaded mouse heart reveals dynamin-related protein 1 as a modulator of cardiac hypertrophy.

Dr. Chen, Chien-Chang
Mol Cell Proteomics., Jul 23, 2013

Pressure-overload stress to the heart causes pathological cardiac hypertrophy, which increases the risk of cardiac morbidity and mortality. However, the detailed signaling pathways induced by pressure overload remain unclear. Here we used phosphoproteomics to delineate signaling pathways in the myocardium responding to acute pressure overload and chronic hypertrophy in mice.