Dr. Chen, Chinpan 's publons link picture


  • 02-26523035 (Lab) (Room No: N133)
  • 02-27887641 (Fax)

  • Structural Biology
  • NMR

Education and Positions:
  • Ph.D. University of Washington

Highlight Detail

Structural Basis of a Physical Blockage Mechanism for the Interaction of Response Regulator PmrA with Connector Protein PmrD from Klebsiella Pneumoniae.

Dr. Chen, Chinpan
J Biol Chem., Jul 16, 2013

In bacteria, the two-component system (TCS) is the most prevalent for sensing and transducing environmental signals into the cell. The PmrA-PmrB TCS, responsible for sensing external stimuli of high Fe3+ and mild acidic conditions, can control the genes involved in lipopolysaccharide modification and polymyxin resistance in pathogens. In Klebsiella pneumoniae, the small basic connector protein PmrD protects phospho-PmrA and prolongs the expression of PmrA-activated genes.