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  • Signal Transduction
  • Gene Regulation
  • Neurodegeneration Disease

Education and Positions:
  • Ph.D. Univ. of Massachusetts

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Modulation of energy deficiency in Huntington's disease via activation of the peroxisome proliferator-activated receptor gamma.

Dr. Chern, Yijuang
Human Molecular Genetics, Aug 06, 2010

Huntington's disease (HD) is a neurodegenerative disease caused by the expansion of a CAG trinucleotide repeat in exon 1 of the huntingtin (HTT) gene. Here, we report that the transcript of the peroxisome proliferator-activated receptor-γ (PPARγ, a transcription factor that is critical for energy homeostasis, was markedly downregulated in multiple tissues of a mouse model (R6/2) of HD and in lymphocytes of HD patients.