陳儀莊博士
所長
特聘研究員
- +886227899028 (Lab) (Room No: N333)
- +886226523913 (Office)
- 02-27829143 (Fax)
-
Specialty:
- Signal Transduction
- Gene Regulation
- Neurodegeneration Disease
Education and Positions:
Ph.D. Univ. of Massachusetts
Highlight Detail
Energy dysfunction in Huntington's disease: insights from PGC-1α, AMPK, and CKB.
Dr. Chern, Yijuang
Cell Mol Life Sci., May 25, 2012Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by a CAG trinucleotide expansion in the Huntingtin (Htt) gene. When the number of CAG repeats exceeds 36, the translated polyglutamine-expanded Htt protein interferes with the normal functions of many types of cellular machinery and causes cytotoxicity.