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  • Signal Transduction
  • Gene Regulation
  • Neurodegeneration Disease

Education and Positions:
  • Ph.D. Univ. of Massachusetts

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A critical role of astrocyte-mediated nuclear factor-κB-dependent inflammation in Huntington's disease.

Dr. Chern, Yijuang
Hum Mol Genet., Jan 30, 2013

Huntington's disease (HD) is an autosomal disease caused by a CAG repeat expansion in the huntingtin (HTT) gene. The resultant mutant HTT protein (mHTT) forms aggregates in various types of cells including neurons and glial cells, and preferentially affects brain function. We found that two HD mouse models (Hdh(150Q) and R6/2) were more susceptible than wild-type (WT) mice to lipopolysaccharide (LPS)-evoked systemic inflammation, and produced more proinflammatory cytokines in the brain.