陳儀莊博士
所長
特聘研究員
- +886227899028 (Lab) (Room No: N333)
- +886226523913 (Office)
- 02-27829143 (Fax)
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Specialty:
- Signal Transduction
- Gene Regulation
- Neurodegeneration Disease
Education and Positions:
Ph.D. Univ. of Massachusetts
Highlight Detail
Activation of AMP- activated protein kinase α1 mediates mislocalization of TDP-43 in amyotrophic lateral sclerosis.
Dr. Chern, Yijuang
Hum Mol Genet., Sep 25, 2014TAR DNA-binding protein-43 (TDP-43) is a nuclear RNA-binding protein involved in many cellular pathways. TDP-43-positive inclusions are a hallmark of amyotrophic lateral sclerosis (ALS). The major clinical presentation of ALS is muscle weakness due to the degeneration of motor neurons. Mislocalization of TDP-43 from the nucleus to the cytoplasm is an early event of ALS.