黃怡萱博士
副所長
研究員
- 02-2789-9174 (Lab) (Room No: N703)
- 02-2652-3523 (Office)
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Specialty:
- Translational Control/ RNA 轉譯調控
- Cap modification/ RNA-cap 修飾調控
- Molecular & Cellular Neuroscience/ 分子與細胞神經生物學
Education and Positions:
Ph.D. University of Texas Southwestern Medical Center at Dallas
Highlight Detail
NMDAR signaling facilitates the IPO5-mediated nuclear import of CPEB3.
Dr. Huang, Yi-Shuian
Nucleic Acids Res., Jun 22, 2012Cytoplasmic polyadenylation element-binding protein (CPEB)3 is a nucleocytoplasm-shuttling RNA-binding protein and predominantly resides in the cytoplasm where it represses target RNA translation. When translocated into the nucleus, CPEB3 binds to Stat5b and downregulates Stat5b-dependent transcription. In neurons, the activation of N-methyl-d-aspartate receptors (NMDARs) accumulates CPEB3 in the nucleus and redistributes CPEB3 in the