Dr. Shen, Chen-Yang 's publons link picture

沈志陽博士

特聘研究員
  • 02-27899036 (Lab) (Room No: N143)
  • 02-27823047 (Fax)

Specialty:
  • Molecular Epidemiology
  • Cancer Genetics
  • Personalized Medicine

Education and Positions:
  • Ph.D. Univ. of North Carolina at Chapel Hill


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Genome-Wide Association Studies for Albuminuria of Nondiabetic Taiwanese Population

Dr. Shen, Chen-Yang
American Journal of Nephrology, Jul 12, 2023

 

 

 

Introduction: Chronic kidney disease, which is defined by a reduced estimated glomerular filtration rate and albuminuria, imposes a large health burden worldwide. Ethnicity-specific associations are frequently observed in genome-wide association studies (GWAS). This study conducts a GWAS of albuminuria in the nondiabetic population of Taiwan. 

Methods: Nondiabetic individuals aged 30–70 years without a history of cancer were enrolled from the Taiwan Biobank. A total of 6,768 subjects were subjected to a spot urine examination. After quality control using PLINK and imputation using SHAPEIT and IMPUTE2, a total of 3,638,350 single-nucleotide polymorphisms (SNPs) remained for testing. SNPs with a minor allele frequency of less than 0.1% were excluded. Linear regression was used to determine the relationship between SNPs and log urine albumin-to-creatinine ratio. 

Results: Six suggestive loci are identified in or near the FCRL3 (p = 2.56 × 10−6), TMEM161 (p = 4.43 × 10−6), EFCAB1 (p = 2.03 × 10−6), ELMOD1 (p = 2.97 × 10−6), RYR3 (p = 1.34 × 10−6), and PIEZO2 (p = 2.19 × 10−7). Genetic variants in the FCRL3 gene that encode a secretory IgA receptor are found to be associated with IgA nephropathy, which can manifest as proteinuria. The PIEZO2 gene encodes a sensor for mechanical forces in mesangial cells and renin-producing cells. Five SNPs with a p-value between 5 × 10−6 and 5 × 10−5 are also identified in five genes that may have a biological role in the development of albuminuria. 

Conclusion: Five new loci and one known suggestive locus for albuminuria are identified in the nondiabetic Taiwanese population.