Dr. Shen, Chen-Yang 's publons link picture

沈志陽博士

特聘研究員
  • 02-27899036 (Lab) (Room No: N143)
  • 02-27823047 (Fax)

Specialty:
  • Molecular Epidemiology
  • Cancer Genetics
  • Personalized Medicine

Education and Positions:
  • Ph.D. Univ. of North Carolina at Chapel Hill


研究的長足進步提供現代生物醫學研究者獨特的機會分析整個基因體中的遺傳變異對複雜疾病發生進展與治療的影響. 更重要的是這種研究策略並不需要研究者對於疾病有任何預先的假設。這種全基因體相關研究(Genome-wide association study, GWAS)已成功發現許多複雜疾病易感性的遺傳因子, 並通過應用新穎的分析方法,當前的研究重點是探討因果變異的易感性便意味點的生物學機制。在我們研究室最近的三項研究中,我們依據此一策略找到了與乳癌進展和高脂血症相關的重要因果變異的分子機轉,這些研究的重點是使用 GWAS的結果,加以分析實驗來深入了解病因。我們使用一系列方法,包括使用生物資訊資料庫(如 eQTL 和 ENCODE)、細胞學分析和 CRISPR/Cas9 基因組編輯系統,我們的研究確定特定的轉錄因子能夠有區別地結合特定的遺傳變異點,進而影響下游基因的表現與疾病的生成。這些研究展現如何進行post-GWAS 研究來產生轉譯醫學的關鍵訊息。
我們實驗室也對乳癌幹細胞感到興趣。我們已經發現出特異性標記物(一種長鏈非編碼RNA)可以鑑定雌激素受體陽性乳癌幹細胞。此外,我們也找到了 microRNA主導的CXCR4/p-Akt 訊息抑制,從而影響了間質幹細胞的發生,這結果可以做為浸潤性乳腺癌治療的標靶。
最後,我們最近引入了新研究策略來探討組蛋白過表現、組蛋白修飾和 DNA 修復對乳腺癌進展的可能影響。

Our Team
Team photo

  1. Chou WC, Chen WT, Kuo CT, Chang YM, Luo YL, Li CW, Hung MC, Shen CY. Genetic Insights into Carbohydrate Sulfotransferase 8 and Its Impact on Immunotherapy Efficacy of Cancer Cell Reports (2023-12) [JCR] [WOS]
  2. Mueller SH, Lai AG, Valkovskaya M, Michailidou K, Bolla MK, Wang Q, Dennis J, Lush M, Abu-Ful Z, Ahearn TU, Andrulis IL, Anton-Culver H, Antonenkova NN, Arndt V, Aronson KJ, Augustinsson A, Baert T, Freeman LEB, Beckmann MW, Behrens S, Benitez J, Bermisheva M, Blomqvist C, Bogdanova NV, Bojesen SE, Bonanni B, Brenner H, Brucker SY, Buys SS, Castelao JE, Chan TL, Chang-Claude J, Chanock SJ, Choi JY, Chung WK, Colonna SV, Cornelissen S, Couch FJ, Czene K, Daly MB, Devilee P, Dork T, Dossus L, Dwek M, Eccles DM, Ekici AB, Eliassen AH, Engel C, Evans DG, Fasching PA, Fletcher O, Flyger H, Gago-Dominguez M, Gao YT, Garcia-Closas M, Garcia-Saenz JA, Genkinger J, Gentry-Maharaj A, Grassmann F, Guenel P, Gundert M, Haeberle L, Hahnen E, Haiman CA, Hakansson N, Hall P, Harkness EF, Harrington PA, Hartikainen JM, Hartman M, Hein A, Ho WK, Hooning MJ, Hoppe R, Hopper JL, Houlston RS, Howell A, Hunter DJ, Huo D, Ito H, Iwasaki M, Jakubowska A, Janni W, John EM, Jones ME, Jung A, Kaaks R, Kang D, Khusnutdinova EK, Kim SW, Kitahara CM, Koutros S, Kraft P, Kristensen VN, Kubelka-Sabit K, Kurian AW, Kwong A, Lacey JV, Lambrechts D, Le Marchand L, Li J, Linet M, Lo WY, Long J, Lophatananon A, Mannermaa A, Manoochehri M, Margolin S, Matsuo K, Mavroudis D, Menon U, Muir K, Murphy RA, Nevanlinna H, Newman WG, Niederacher D, O\'Brien KM, Obi N, Offit K, Olopade OI, Olshan AF, Olsson H, Park SK, Patel AV, Patel A, Perou CM, Peto J, Pharoah PDP, Plaseska-Karanfilska D, Presneau N, Rack B, Radice P, Ramachandran D, Rashid MU, Rennert G, Romero A, Ruddy KJ, Ruebner M, Saloustros E, Sandler DP, Sawyer EJ, Schmidt MK, Schmutzler RK, Schneider MO, Scott C, Shah M, Sharma P, Shen CY, Shu XO, Simard J, Surowy H, Tamimi RM, Tapper WJ, Taylor JA, Teo SH, Teras LR, Toland AE, Tollenaar RAEM, Torres D, Torres-Mejia G, Troester MA, Truong T, Vachon CM, Vijai J, Weinberg CR, Wendt C, Winqvist R, Wolk A, Wu AH, Yamaji T, Yang XR, Yu JC, Zheng W, Ziogas A, Ziv E, Dunning AM, Easton DF, Hemingway H, Hamann U, Kuchenbaecker KB Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry. Genome medicine 15(1), 7 (2023) [JCR] [WOS]
  3. Yang WS, Chuang GT, Che TP, Chueh LY, Li WY, Hsu CN, Hsiung CN, Ku HC, Ching LY, Chen YS, Hee SW, Chang TJ, Chen SM, Hsieh ML, Lee HL, Liao KC, Shen CY, Chang YC Genome-Wide Association Studies for Albuminuria of non-Diabetic Taiwanese Population American journal of nephrology doi: 10.1159/000531783, 1-11 (2023) [JCR] [WOS]
  4. Huang HC, Wang SH, Fang GC, Chou WC, Liao CC, Sun CP, Jan JT, Ma HH, Ko HY, Ko YA, Chiang MT, Liang JJ, Kuo CT, Lee TA, Morales-Scheihing D, Shen CY, Chen SY, McCullough LD, Cui L, Wernig G, Tao MH, Lin YL, Chang YM, Wang SP, Lai YJ, Li CW Upregulation of PD-L1 by SARS-CoV-2 promotes immune evasion. Journal of medical virology 95(2), e28478 (2023) [JCR] [WOS]
  5. Chou WC, Chen WT, Shen CY A common variant in 11q23.3 associated with hyperlipidemia is mediated by the binding and regulation of GATA4. NPJ genomic medicine 7(1), 4 (2022) [JCR] [WOS]
  6. Liu PH, Chuang GT, Hsiung CN, Yang WS, Ku HC, Lin YC, Chen YS, Huang YY, Lin CH, Li WY, Lin JW, Hsu CN, Hwang JJ, Liao KC, Hsieh ML, Lee HL, Shen CY, Chang YC A genome-wide association study for melatonin secretion. Scientific reports 12(1), 8025 (2022) [JCR] [WOS]
  7. Jia G, Ping J, Shu X, Yang Y, Cai Q, Kweon SS, Choi JY, Kubo M, Park SK, Bolla MK, Dennis J, Wang Q, Guo X, Li B, Tao R, Aronson KJ, Chan TL, Gao YT, Hartman M, Ho WK, Ito H, Iwasaki M, Iwata H, John EM, Kasuga Y, Kim MK, Kurian AW, Kwong A, Li J, Lophatananon A, Low SK, Mariapun S, Matsuda K, Matsuo K, Muir K, Noh DY, Park B, Park MH, Shen CY, Shin MH, Spinelli JJ, Takahashi A, Tseng C, Tsugane S, Wu AH, Yamaji T, Zheng Y, Dunning AM, Pharoah PDP, Teo SH, Kang D, Easton DF, Simard J, Shu XO, Long J, Zheng W Genome- and transcriptome-wide association studies of 386,000 Asian and European-ancestry women provide new insights into breast cancer genetics. American journal of human genetics 109(12), 2185-2195 (2022) [JCR] [WOS]
  8. Wong HS, Tsai SY, Chu HW, Lin MR, Lin GH, Tai YT, Shen CY, Chang WC Genome-wide association study identifies genetic risk loci for adiposity in a Taiwanese population. PLoS genetics 18(1), e1009952 (2022) [JCR] [WOS]
  9. Grootes I, Keeman R, Blows FM, Milne RL, Giles GG, Swerdlow AJ, Fasching PA, Abubakar M, Andrulis IL, Anton-Culver H, Beckmann MW, Blomqvist C, Bojesen SE, Bolla MK, Bonanni B, Briceno I, Burwinkel B, Camp NJ, Castelao JE, Choi JY, Clarke CL, Couch FJ, Cox A, Cross SS, Czene K, Devilee P, Dork T, Dunning AM, Dwek M, Easton DF, Eccles DM, Eriksson M, Ernst K, Evans DG, Figueroa JD, Fink V, Floris G, Fox S, Gabrielson M, Gago-Dominguez M, Garcia-Saenz JA, Gonzalez-Neira A, Haeberle L, Haiman CA, Hall P, Hamann U, Harkness EF, Hartman M, Hein A, Hooning MJ, Hou MF, Howell SJ, Ito H, Jakubowska A, Janni W, John EM, Jung A, Kang D, Kristensen VN, Kwong A, Lambrechts D, Li J, Lubinski J, Manoochehri M, Margolin S, Matsuo K, Taib NAM, Mulligan AM, Nevanlinna H, Newman WG, Offit K, Osorio A, Park SK, Park-Simon TW, Patel AV, Presneau N, Pylkas K, Rack B, Radice P, Rennert G, Romero A, Saloustros E, Sawyer EJ, Schneeweiss A, Schochter F, Schoemaker MJ, Shen CY, Shibli R, Sinn P, Tapper WJ, Tawfiq E, Teo SH, Teras LR, Torres D, Vachon CM, van Deurzen CHM, Wendt C, Williams JA, Winqvist R, Elwood M, Schmidt MK, Garcia-Closas M, Pharoah PDP Incorporating progesterone receptor expression into the PREDICT breast prognostic model. European journal of cancer (Oxford, England : 1990) 173, 178-193 (2022) [JCR] [WOS]
  10. Liao WL, Liu YF, Ying TH, Shieh JC, Hung YT, Lee HJ, Shen CY, Cheng CW Inhibitory Effects of Ursolic Acid on the Stemness and Progression of Human Breast Cancer Cells by Modulating Argonaute-2. International journal of molecular sciences 24(1), 366 (2022) [JCR] [WOS]