Ph.D, State University of New York at Stony Brook, USA
Hepatocellular adenoma (HCA) is a frequent long-term complication of type I glycogen storage disease (GSD I) and malignant transformation to hepatocellular carcinoma (HCC) is known to occur in some cases. However, the molecular pathogenesis of tumor development in GSD I is unclear. This study was conducted to systematically investigate chromosomal and genetic alterations in HCA associated with GSD I.