李玲慧博士
研究技師
- 02-2789-9078 (Lab) (Room No: N618)
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Specialty:
- Cancer Genomics
- Human Molecular Genetics
Education and Positions:
Ph.D, State University of New York at Stony Brook, USA
全基因體SNP基因型鑑定是尋找疾病易感性基因及藥物不良反應基因的利器。我的職責之一即在確保此實驗平台的品質。同時我也投入研發工作，發展平台新的應用方向及新的分析方法，以協助研究者能充分利用此平台進行研究工作。與統計學者合作的分析軟體:染色體異常偵測大師(ALICE)可以偵測基因型鑑定晶片各種染色體異常現象，榮獲2018科技部未來科技展展示獎項。目前本人利用此實驗平台的資料與臨床醫師合作尋找與精神疾病、誘導性多功能幹細胞、及癌症相關的DNA拷貝數異常。為了提供漢人族群更完善的全基因體SNP基因型鑑定晶片，我也參與兩組客製化晶片，TPM(TWB2)以及TPM2的晶片設計與開發工作。
本實驗室的研究主要在了解大腸直腸癌的癌化機制。我們整合染色體異常變化、異常基因表現、與異常miRNA表現的資料，來尋找與大腸直腸癌癌化相關的基因。透過整合分析，我們已經找到一些可能與癌症形成相關的基因。目前我們選定幾個基因研究它們參與癌症形成的機轉，並評估它們作為診斷或病情進展的生物標記之可能性。另外我們也透過次世代定序找到一些與大腸直腸癌癌化相關的細菌。未來我們會聚焦在這些細菌如何影響腸道細胞，以及這些細菌與腸道細胞交互作用如何誘發大腸直腸癌產生。
期刊 42
專書 0
期刊 42 專書 0
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