Dr. Li, Ling-Hui 's publons link picture

李玲慧博士

研究技師
  • 02-2789-9078 (Lab) (Room No: N618)
Specialty:
  • Cancer Genomics
  • Human Molecular Genetics
Education and Positions:

  • Ph.D, State University of New York at Stony Brook, USA

全基因體SNP基因型鑑定是尋找疾病易感性基因及藥物不良反應基因的利器。我的職責之一即在確保此實驗平台的品質。同時我也投入研發工作，發展平台新的應用方向及新的分析方法，以協助研究者能充分利用此平台進行研究工作。與統計學者合作的分析軟體:染色體異常偵測大師(ALICE)可以偵測基因型鑑定晶片各種染色體異常現象，榮獲2018科技部未來科技展展示獎項。目前本人利用此實驗平台的資料與臨床醫師合作尋找與精神疾病、誘導性多功能幹細胞、及癌症相關的DNA拷貝數異常。為了提供漢人族群更完善的全基因體SNP基因型鑑定晶片，我也參與兩組客製化晶片，TPM(TWB2)以及TPM2的晶片設計與開發工作。

本實驗室的研究主要在了解大腸直腸癌的癌化機制。我們整合染色體異常變化、異常基因表現、與異常miRNA表現的資料，來尋找與大腸直腸癌癌化相關的基因。透過整合分析，我們已經找到一些可能與癌症形成相關的基因。目前我們選定幾個基因研究它們參與癌症形成的機轉，並評估它們作為診斷或病情進展的生物標記之可能性。另外我們也透過次世代定序找到一些與大腸直腸癌癌化相關的細菌。未來我們會聚焦在這些細菌如何影響腸道細胞，以及這些細菌與腸道細胞交互作用如何誘發大腸直腸癌產生。

期刊 42 專書 0

  1. Binay K. Sahoo, Yuh-Charn Lin, Cheng-Fen Tu, Chien-Chin Lin, Wei-Ju Liao, Fu-An Li, (Ling-Hui Li), Yun Mou, Steve R. Roffler, Shu-Ping Wang, Chi-Tai Yeh, Chi-Yuan Yao, Hsin-An Hou, Wen-Chien Chou, Hwei-Fang Tien, Ruey-Bing Yang* Signal peptide-CUB-EGF-like repeat-containing protein 1-promoted FLT3 signaling is critical for the initiation and maintenance of MLL-rearranged acute leukemia. Haematologica 108, 5 (2023-05) [JCR] [WOS]
  2. Chia-Hui Lo, Deng-Chyang Wu, Shu-Wen Jao, Chang-Chieh Wu, Chung-Yen Lin, Chia-Hsien Chuang, Ya-Bo Lin, Chien-Hsiun Chen, Ying-Ting Chen, Jiann-Hwa Chen, Koung-Hung Hsiao, Ying-Ju Chen, Yuan-Tsong Chen, Jaw-Yuan Wang*, (Ling-Hui Li)* Enrichment of Prevotella intermedia in human colorectal cancer and its additive effects with Fusobacterium nucleatum on the malignant transformation of colorectal adenomas. JOURNAL OF BIOMEDICAL SCIENCE 29, 88 (2022-10-27) [JCR] [WOS]
  3. Cheng-Fen Tu, Fu-An Li, (Ling-Hui Li) and Ruey-Bing Yang* Quantitative glycoproteomics analysis identifies novel FUT8 targets and signaling networks critical for breast cancer cell invasiveness. BREAST CANCER RESEARCH 24, 21 (2022-03) [JCR] [WOS]
  4. Wei Chun-Yu, Yang Jenn-Hwai, Yeh Erh-Chan, Tsai Ming-Fang, Kao Hsiao-Jung, Lo Chen-Zen, Chang Lung-Pao, Lin Wan-Jia, Hsieh Feng-Jen, Belsare Saurabh, Bhaskar Anand, Su Ming-Wei, Lee Te-Chang, Lin Yi-Ling, Liu Fu-Tong, Shen Chen-Yang, (Li Ling-Hui), Chen Chien-Hsiun, Wall Jeffrey D., Wu Jer-Yuarn, Kwok Pui-Yan* Genetic profiles of 103,106 individuals in the Taiwan Biobank provide insights into the health and history of Han Chinese. npj Genomic Medicine 6(1), 10 (2021-02) [JCR] [WOS]
  5. Chen Yen-Cheng, Miao Zhi-Feng, Yip Kwan-Ling, Cheng Yi-An, Liu Chung-Jung, (Li Ling-Hui), Lin Chung-Yen, Wang Jiunn-Wei, Wu Deng-Chyang, Cheng Tian-Lu, Wang Jaw-Yuan* Gut Fecal Microbiota Transplant in a Mouse Model of Orthotopic Rectal Cancer. Frontiers in Oncology 10, 568012 (2020-10) [JCR] [WOS]
  6. Huang Ching-Ying, (Li Ling-Hui), Hsu Wan-Tseng, Cheng Yu-Che, Nicholson Martin W., Liu Chun-Lin, Ting Chien-Yu, Ko Hui-Wen, Syu Shih-Han, Wen Cheng-Hao, Yan Zhuge, Huang Hsiang-Po, Su Hong-Lin, Chiang Po-Min, Shen Chia-Ning, Chen Hsin-Fu, Yen B. Lin Ju, Lu Huai-En, Hwang Shiaw-Min, Chiou Shih-Hwa, Ho Hong-Nerng, Wu Jer-Yuarn, Kamp Timothy J., Wu Joseph C., Hsieh Patrick C. H.* Copy number variant hotspots in Han Taiwanese population induced pluripotent stem cell lines - lessons from establishing the Taiwan human disease iPSC Consortium Bank. Journal of Biomedical Science 27(1), 92 (2020-09) [JCR] [WOS]
  7. Shen Wen-Ching, Lai Yung-Chih, (Li Ling-Hui), Liao Kolin, Lai Hung-Chang, Kao Shou-Yen, Wang John, Chuong Cheng-Ming, Hung Shih-Chieh* Methylation and PTEN activation in dental pulp mesenchymal stem cells promotes osteogenesis and reduces oncogenesis. Nature Communications 10(1), 2226 (2019-05) [JCR] [WOS]
  8. Chen CH, Chen HI, Chien WH, (Li LH), Wu YY, Chiu YN, Tsai WC, Gau SS* High resolution analysis of rare copy number variants in patients with autism spectrum disorder from Taiwan. Scientific reports 7(1), 11919 (2017-09) [JCR] [WOS]
  9. Chuang, T.P., Wang, J.Y., Jao, S.W., Wu, C.C., Chen, J.H., Hsiao, K.H., Lin, C.Y., Chen, S.H., Su, S.Y., Chen, Y.J., Chen, Y.T., Wu, D.C.*, (Li, L.H.)* Over-expression of AURKA, SKA3 and DSN1 contributes to colorectal adenoma to carcinoma progression.. Oncotarget 7(29), 45803-45818 (2016-06) [JCR] [WOS]
  10. Lin, Y.-F., (Li, L.-H.), Lin, C.-H., Tsou, M.-H., Chuang, M.-T.K., Wu, K.-M., Liao, T.-L., Li, J.-C., Wang, W.-J., Tomita, A., Tomita, B., Huang, S.-F., Tsai, S.-F.* Selective Retention of an Inactive Allele of the DKK2 Tumor Suppressor Gene in Hepatocellular Carcinoma. PLoS Genetics 12, e1006051 (2016-05) [JCR] [WOS]
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2018 Future Tech Award (MOST)